Patents Represented by Attorney, Agent or Law Firm Joan Switzer
  • Microbial transformation method for the preparation of an epothilone
    Patent number: 6780620
    Abstract: A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: August 24, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wenying Li, James A. Matson, Xiaohua Huang, Kin Sing Lam, Grace A. McClure
  • 12, 13-cyclopropane epothilone derivatives
    Patent number: 6380395
    Abstract: The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: April 30, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Gerhard Höfle