Patents Represented by Attorney Joel Silver
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Patent number: 8168201Abstract: The present invention relates to compositions for inducing immune responses, including an antigen and a promiscuous T-cell epitope. Also provided are methods of inducing immune responses in hosts, comprising administering compositions comprising antigens and promiscuous T-cell epitopes to the host.Type: GrantFiled: April 3, 2007Date of Patent: May 1, 2012Assignee: Pfizer Canada Inc.Inventors: Leslie Hickle, Abraham Anderson, Robert C. Brown, Paul Budworth, Gordana Djordjevic, Scott Kroken, Peter Luginbuhl, Toby Richardson, Genevieve Hansen
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Patent number: 8002721Abstract: The present invention is directed to a thermal covering that delivers consistent therapy to a portion of a user's hand-wrist area, is easy to use and apply to the body, and is securely positionable on the body. The thermal covering can be entirely disposable after one use. The thermal covering can also have a disposable component and a reusable component that can be packaged individually together as a kit.Type: GrantFiled: September 7, 2007Date of Patent: August 23, 2011Assignee: Wyeth LLCInventors: Donald Stephen Bretl, Mary Elaine Freeland, Kyle William Harris, Richard W. Pack, Angela Marie Reed
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Patent number: 7906128Abstract: The present invention provides an effective method and composition for the prevention, amelioration or control of external parasites on a human or animal via the administration of a prophylactically, therapeutically or pharmaceutically effective amount of a neuronal sodium channel antagonist to a human or animal in need thereof.Type: GrantFiled: October 14, 2003Date of Patent: March 15, 2011Assignee: Wyeth LLCInventors: Kathleen Heaney, Susan J. Dunney, Douglas Rugg
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Patent number: 7906130Abstract: The present invention provides a stable composition which comprises a non-hydroxyl-group-containing solvent mixture comprising N,N-diethyl-m-toluamide and ?-hexalactone, optionally with dimethyl sulfoxide, eucalyptol and 1-methoxy-2-propyl acetate; and an effective amount of each of amitraz and at least one additional parasiticidal compound, such as R-28153. Said composition allows for high concentrations of a mixture of parasiticidal agents in a single application and is useful for treating and controlling parasiticidal infection and infestation in a homeothermic animal.Type: GrantFiled: October 7, 2005Date of Patent: March 15, 2011Assignee: Wyeth LLCInventors: Shobhan Shashi Sabnis, Jacob A. Zupan, Robert Bruce Albright
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Patent number: 7878187Abstract: The present invention is directed to heat cells that are suitable for incorporation into disposable heating wraps. The heat cells comprise an exothermic composition comprising an absorbent gelling material, wherein the absorbent gelling material provides for improved heat application in the relief of temporary or chronic body aches and pains.Type: GrantFiled: September 23, 2005Date of Patent: February 1, 2011Assignee: Wyeth LLCInventor: Vincent York-Leung Wong
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Patent number: 7879826Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: wherein: A is alkylenyl of 1 to 4 carbon atoms, or alkenylenyl of 2 to 4 carbon atoms; R1 and R2 are, independently, hydrogen or a C5 to C7 aryl optionally substituted with 1 to 2 substituents, independently, selected from the group consisting of —C(O)R3, halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy, with the proviso that at least one of R1 and R2 is not hydrogen; R3 is, independently, hydrogen, —OR4, alkyl, aryl, or heteroaryl; R4 is hydrogen, alkyl, aryl, or heteroaryl; R5 and R6 are, independently, hydrogen, alkyl, hydroxyl, alkoxy, or C5 to C7 aryl; wherein any R3 to R6 group having an aryl or heteroaryl moiety can optionally be substituted on the aryl or heteroaryl moiety with 1 to about 5 substituents, independently, selected from the group consisting of halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy.Type: GrantFiled: June 5, 2007Date of Patent: February 1, 2011Assignee: Wyeth LLCInventor: Reinhardt Bernhard Baudy
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Patent number: 7879825Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided where at least one of R2 or R3 is not hydrogen. The compounds of the present invention are N-methyl-D-aspartate (NMDA) receptor antagonists and are useful in treating a variety of conditions present in a mammal that benefit from inhibiting the NMDA receptor.Type: GrantFiled: June 1, 2007Date of Patent: February 1, 2011Assignee: Wyeth LLCInventors: Reinhardt B. Baudy, John A. Butera
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Patent number: 7856948Abstract: Disclosed herein are compositions which are exothermic upon contact with oxygen and are self-steaming. The various described embodiments include compositions comprising: (a) a fuel component; (b) a water manager component; and (c) water. In one embodiment, the water manager component, has a mean particle size distribution of greater than about 250 microns. Alternatively or additionally, the ratio of the water manager component to the water is from about 0.001:1 to about 0.2:1, by weight. Alternatively or additionally, the fuel component comprises sponge iron. Alternatively or additionally, the composition comprises a volatile component. In yet another embodiment, articles comprising the compositions are described. Further, methods of making the compositions are described.Type: GrantFiled: March 2, 2005Date of Patent: December 28, 2010Assignee: Wyeth LLCInventors: Vincet York-Leung Wong, Kenneth John Edelman, Donald Louis Horning, Robert Henry Rohrbaugh, Brian Joseph Roselle
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Patent number: 7563813Abstract: Compounds of Formula 1, or pharmaceutically acceptable salts thereof, are provided: which are inhibitors of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis.Type: GrantFiled: May 10, 2006Date of Patent: July 21, 2009Assignee: WyethInventors: Ariamala Gopalsamy, Mengxiao Shi
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Patent number: 7553634Abstract: A process is described for extracting gram-negative integral membrane proteins from bacteria or bacterial host cells containing a recombinant vector by differential detergent tangential flow diafiltration. This process has several advantages over alternate processes. First, it combines the clarification and extraction processes into one unit operation. The product is extracted from the cells and it is separated from cell debris with only one continuous diafiltration process. Second, the membrane proteins are extracted in a semi-purified state, which simplifies the downstream processing steps. Third, this process is very scalable because the only requirement is that the surface area of the membranes be increased proportionally with the amount of cells.Type: GrantFiled: June 20, 2000Date of Patent: June 30, 2009Assignee: Wyeth Holdings CorporationInventors: Sanjay Lakhotia, Michael R. Biehl
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Patent number: 7524849Abstract: This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 24, 2004Date of Patent: April 28, 2009Assignee: Wyeth Holdings CorporationInventors: Nan Zhang, Semiramis Ayral-Kaloustian, Thai Nguyen
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Patent number: 7495027Abstract: The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof.Type: GrantFiled: August 9, 2004Date of Patent: February 24, 2009Assignee: WyethInventors: Craig Eugene Caufield, Schuyler Adam Antane, Koi Michele Morris, Shaughnessy McGrath Naughton, Dominick Anthony Quagliato, Patrick Michael Andrae, Annmarie Enos, John F. Chiarello
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Patent number: 7488832Abstract: The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.Type: GrantFiled: February 13, 2006Date of Patent: February 10, 2009Assignee: WyethInventors: Derek Cecil Cole, Eric Steven Manas, Lee Dalton Jennings, Frank Eldridge Lovering, Joseph Raymond Stock, William Jay Moore, John Watson Ellingboe, Jeffrey Scott Condon, Mohani Nirmala Sukhdeo, Ping Zhou, Junjun Wu, Koi Michele Morris
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Patent number: 7456186Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.Type: GrantFiled: June 15, 2005Date of Patent: November 25, 2008Assignee: WyethInventors: Michael S. Malamas, James J. Erdei, Iwan S. Gunawan, Keith Douglas Barnes, Matthew Robert Johnson, Yu Hui
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Patent number: 7417047Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.Type: GrantFiled: June 29, 2006Date of Patent: August 26, 2008Assignee: WyethInventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato