Patents Represented by Attorney John A. Dhuey
  • Patent number: 6284274
    Abstract: An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: September 4, 2001
    Assignee: Alza Corporation
    Inventors: Sonya Merrill, Atul D. Ayer, Paul M. Hwang, Anthony L. Kuczynski, Nils W. Ahlgren, Deborah J. Johnson
  • Patent number: 6262115
    Abstract: A composition and a dosage form are disclosed comprising oxybutynin alone/or accompanied by another drug indicated for therapy. A method is disclosed for administering oxybutynin alone/or accompanied by a different drug or for administering oxybutynin and a different drug according to a therapeutic program for the management of incontinence alone, and for other therapy.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: July 17, 2001
    Assignee: ALZA Coporation
    Inventors: George V. Guittard, Francisco Jao, Susan M. Marks, David J. Kidney, Fernando E. Gumucio
  • Patent number: 6245357
    Abstract: A dosage form comprising a composition comprising a drug surrounded by an interior and an exterior wall with an exit for administering the drug to a patient; and a method of using the dosage form are disclosed for an indicated therapy.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: June 12, 2001
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Shu Li, Gurdish Kaur Bhatti, Patrick S. L. Wong, Robert R. Skluzacek
  • Patent number: 6190351
    Abstract: A nutritional system is disclosed, for delivering a colorant dye to a nutritional fluid that flows through the nutritional system.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: February 20, 2001
    Assignee: ALZA Corporation
    Inventors: Richard G. Weyers, Atul D. Ayer, Brenda J. Pollock, Brian L. Barclay, Ernest S. Quan
  • Patent number: 6183466
    Abstract: A dosage form is disclosed comprising a wall that defines an injection-molded compartment housing a capsule comprising a drug formulation.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: February 6, 2001
    Assignee: Alza Corporation
    Inventors: Patrick S. L. Wong, Felix Theeuwes, Vincent J. Ferrari, Liang C. Dong
  • Patent number: 6174547
    Abstract: A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.
    Type: Grant
    Filed: July 14, 1999
    Date of Patent: January 16, 2001
    Assignee: ALZA Corporation
    Inventors: Liang-Chang Dong, Steven Espinal, Patrick S. L. Wong
  • Patent number: 6153678
    Abstract: Polymeric compositions are disclosed comprising a poly(caprolactone), a poly(alkylene oxide), a poly(oxyethylenated fatty acid ester), or a poly(oxyethylenated fatty acid), or a poly(oxyethylene-co-oxypropylene).
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: November 28, 2000
    Assignee: Alza Corporation
    Inventors: Liang-Chang Dong, Crystal Pollock, Patrick S.-L. Wong, Keru O. Shafi, Vincent J. Ferrari, Ted Smith
  • Patent number: 6130200
    Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: October 10, 2000
    Assignee: Alza Corporation
    Inventors: Kevin J. Brodbeck, Ann T. Gaynor-Duarte, Theodore Tao-Ian Shen
  • Patent number: 6120803
    Abstract: The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
    Type: Grant
    Filed: August 10, 1998
    Date of Patent: September 19, 2000
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Liang-Chang Dong, David E. Edgren, Felix Theeuwes, Phyllis I. Gardner, Francisco Jao, Jason J. Wan
  • Patent number: 6110499
    Abstract: A therapeutic composition, a dosage form and a method are disclosed for administering phenytoin indicated for the management of epilepsy.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: August 29, 2000
    Assignee: ALZA Corporation
    Inventors: Padmaja Shivanand, Zahedeh Hatamkhany, Barbara F. Laidlaw, Atul D. Ayer
  • Patent number: 6077538
    Abstract: An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: June 20, 2000
    Assignee: Alza Corporation
    Inventors: Sonya Merrill, Atul D. Ayer, Paul M. Hwang, Anthony L. Kuczynski, Nils W. Ahlgren, Deborah J. Johnson
  • Patent number: 6008187
    Abstract: The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium salicylate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration, the amount of oil being from about 10 wt % to about 30 wt %, preferably from about 15 wt % to about 25 wt %, of the total formulation and the amount of sodium salicylate being from about 70 wt % to about 90 wt %, preferably from about 75 wt % to about 85 wt %, of the total formulation. The polypeptide may be non-lyophilized. The pharmaceutical formulation is characterized as a solid, which provides a convenient and improved format for handling and storage and for the preparation of oral dosage forms (such as pills, capsules and delivery vessels) containing a homogeneous mixture of ingredients.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: December 28, 1999
    Assignee: Alza Corporation
    Inventors: Heechung Yang, Vu Anh Nguyen, Liang C. Dong, Patrick S. L. Wong
  • Patent number: 5938654
    Abstract: A dispenser for use in a fluid environment of use which is capable of the delivery of one or a plurality of discrete active agent-containing units in any desired delivery pattern or profile. It also can provide for the initially delayed delivery of an active agent to the environment of use and for high accuracy in the timing of delivery of the active agent.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: August 17, 1999
    Assignee: Alza Corporation
    Inventors: Patrick S.-L. Wong, Felix Theeuwes, James B. Eckenhoff, Steven D. Larsen, Hoa T. Huynh
  • Patent number: 5902605
    Abstract: The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation of the device being of a predetermined length of time. The delivery of the agent formulation from the dispensing device is continued until essentially all of the active agent formulation is delivered as a result of the fluid inhibition into a fluid flow path in the housing of the device and the expansion of an expansion agent in the active agent delivery chamber.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: May 11, 1999
    Assignee: Alza Corporation
    Inventors: Liang C. Dong, Patrick S.-L. Wong, Si-Hong Yum, Crystal Pollock
  • Patent number: 5869096
    Abstract: An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: February 9, 1999
    Assignee: Alza Corporation
    Inventors: Brian L. Barclay, Jerry D. Childers, Jeri Wright, Virgil A. Place, Patrick S. L. Wong
  • Patent number: 5817335
    Abstract: The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The dispensing device is formed of a first and second housing that are in reversibly sliding telescoping arrangement with each other. The first housing contains the active agent formulation and has an aspect ratio less than 1. The housings are preferably. ovoloid in shape.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: October 6, 1998
    Assignee: ALZA Corporation
    Inventors: Patrick S.-L. Wong, Liang C. Dong, Vincent J. Ferrari, Jeri D. Wright, Steven D. Larsen
  • Patent number: 5817624
    Abstract: The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium 3-nitrobenzoate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 6, 1998
    Assignee: Alza Corporation
    Inventors: Heechung Yang, Robert E. Myrback, Deborah A. Fox, Vu Anh Nguyen
  • Patent number: 5800422
    Abstract: The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation of the device being of a predetermined length of time. The delivery of the agent formulation from the dispensing device is continued until essentially all of the active agent formulation is delivered as a result of the expansion of an expansion agent in the active agent delivery chamber.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: September 1, 1998
    Assignee: Alza Corporation
    Inventors: Liang C. Dong, Patrick S.-L. Wong, Si-Hong A. Yum, Lawrence G. Hamel, Michael H. Dealey
  • Patent number: 5780058
    Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber (10) containing the active agent formulation and having a fluid passing active agent formulation retainer (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber.
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: July 14, 1998
    Assignee: ALZA Corporation
    Inventors: Patrick S.-L. Wong, Howard B. Rosen, Nathan Roth, Phyllis I. Gardner
  • Patent number: 5728088
    Abstract: A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may include means for adapting the end cap for ultrasonic welding to the first wall section and means for maintaining the beneficial agent in contact with exit means. The compartment comprises a beneficial agent and an expandable means. The delivery system comprises exit means for delivering the beneficial agent to the animal.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: March 17, 1998
    Assignee: ALZA Corporation
    Inventors: Judy A. Magruder, James B. Eckenhoff, Richard Cortese, Jeremy C. Wright, John R. Peery, James B. Pike, Urano A. Robinson, Jonathan P. Smith, Lyle E. Ziemann