Patents Represented by Attorney John Bailey

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  • Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
    Patent number: 5039705
    Abstract: This invention concerns anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently chosen from straight chain and branched chain C.sub.1 -C.sub.12 alkyl groups and benzyl, with the proviso that no branch occur on the alpha carbon atom of the alkyl groups; or R.sub.1 and R.sub.2 together with the nitrogen atom they are bonded to form a pyrrolidino, piperidino, piperazino or morpholino group, M.sup.+ is a pharmaceutically acceptable cation, wherein X is the valence of the cation.
    Type: Grant
    Filed: September 15, 1989
    Date of Patent: August 13, 1991
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Larry K. Keefer, David A. Wink, Tambra M. Dunams, Joseph A. Hrabie
  • Water soluble prodrugs of camptothecin
    Patent number: 4943579
    Abstract: Water-soluble derivatives of camptothecin have the formulae: ##STR1## wherein R' is selected from the group consisting of R=CO CH.sub.2 NH.sub.2.HClR=CO CH.sub.2 NHCH.sub.3.HClR=CO CH.sub.2 NHC.sub.2 H.sub.5.HClR=CO CH.sub.2 N(C.sub.2 H.sub.5).sub.2.HClR=CO CH(NH.sub.2) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2.2HClR=CO CH(NH.sub.2) CH.sub.2 CH.sub.2 COOH. HClR=CO CH.sub.2 CH.sub.2.COO.sup.- Na.sup.+R=HPO.sub.3.sup.- Na.sup.
    Type: Grant
    Filed: October 6, 1987
    Date of Patent: July 24, 1990
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: B. Rao Vishnuvajjala, Aaron Garzon-Aburbeh