Patents Represented by Attorney John Burke

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  • Bradykinin antagonists
    Patent number: 5863899
    Abstract: A bradykinin antagonist of the formula:(BKAn) (X) (Y)where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: January 26, 1999
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Val Smith Goodfellow, Manoj Vinayak Marathe, Lyle W. Spruce, Eric T. Whalley
  • Bradykinin antagonists
    Patent number: 5620958
    Abstract: A bradykinin antagonist of the formula:X(BKA).sub.nwherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonists of the formula X(BKA) are also disclosed. Also disclosed are bradykinin antagonists of the formula:(Y)(X)(BKA)where X and BKA have the meanings indicated above and Y is the peptide chain of an antagonist or agonist for a non-bradykinin receptor.
    Type: Grant
    Filed: April 13, 1994
    Date of Patent: April 15, 1997
    Assignee: Coretech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Eric T. Whalley, Shadrach R. Eubanks, Lisa G. Allen, Khe T. Nguyen
  • Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
    Patent number: 5618792
    Abstract: The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: April 8, 1997
    Assignee: Cortech, Inc.
    Inventors: Albert Gyorkos, Lyle W. Spruce
  • Bradykinin receptor antagonists with neurokinin receptor blocking activity
    Patent number: 5610140
    Abstract: The present invention provides a heterodimeric compound possessing bradykinin and neurokinin receptor antagonist activities useful in the treatment of asthma and other inflammatory diseases especially those involving the airway or pulmonary system. The present invention is also useful in the treatment of pain and inflammation.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: March 11, 1997
    Assignee: Cortech, Inc.
    Inventors: Val S. Goodfellow, Eric T. Whalley, Francine E. Wincott