Abstract: A collapsible medical agent container (10) is disclosed having walls (34, 36, 38) defining a plurality of chambers (12, 14) for containing selected quantities of one or more medical fluids or a dry or encapsulated drug or other reagent in separate sealed condition. Opening means which communicates between adjacent chambers (12, 14) for passage of fluid from one chamber to another, is normally closed by frangible closure (18) which maintains the chambers (12, 14) in separate hermetically sealed condition until flow between the chambers (12, 14) is needed. The frangible closure (18) has an elongated relatively rigid portion (20) which extends into one of the chambers and is disposed within a protective retentive tube (24), and a relatively weakened portion (22) adjacent the opening means.

Abstract: A method of manufacturing a tear-off port protector for a container comprises placing flexible, typically extruded tubing on a mandrel that fills the bore of the tubing, with the tubing preferably outwardly stretched by the mandrel. A cutting blade is spaced a predetermined distance of less than the tubing wall thickness from the mandrel. One then causes the cutting blade to form an annular cut about the tubing, while maintaining the predetermined distance, and thereafter one removes the tubing from the mandrel.

Abstract: An aqueous red cell storage solution for packed cells which permits removal of essentially all plasma from a unit of blood, followed by reconstitution of the packed cells of the unit in preferably about 80 to 150 ml. of solution for improved cell viability on long term storage. The red cell storage solution contains adenine, glucose or fructose, sodium chloride, and mannitol.

Abstract: Improved valves for use within medical devices include a valve body having a plurality of fluid-passing openings, a resilient liner having raised portions defining flow paths, and a plug having a configuration generally complementary to that of the liner, at least a portion of the plug generally overlying the liner for maintaining raised portions of the liner in sealing engagement with the valve body in a manner that enhances valve integrity as to leakage while simultaneously improving valve operation by providing easy rotation of the plug and liner with respect to the valve body. The in-use illustrated embodiment of the valve is on a urine drainage device, the valve being interposed between a relatively rigid urine flow monitoring and measuring chamber and a flexible collection receptacle, the valve permitting flow path selections for retaining urine within the measuring chamber or for flowing urine therefrom into the flexible collection receptacle or through a sampling port.

Abstract: Blood plasma is frozen in a sealed, flexible, collapsible container which defines an inlet at one end and a shoulder portion surrounding the inlet. The container tapers from the shoulder portion to a generally flat configuration at its end opposite the one end. After the freezing step, the shoulder portion is cut away from the container to define a cut end. Thereafter, the frozen plasma may be removed from the container in frozen form by squeezing the wall of the tapered container to expel the frozen plasma out of the cut end of the container.