Abstract: The present invention relates to a method of decreasing body weight in a patient. The method includes the step of administering a therapeutically effective amount of a type-5 selective somatostatin agonist to the patient.
Type:
Grant
Filed:
May 13, 1998
Date of Patent:
December 21, 1999
Assignee:
Biomeasure, Incorporated
Inventors:
Michael Anthony Cawthorne, Yong-Ling Liu, Matthew V. Sennitt
Abstract: Peptide variants of fragment (1-34) of parathyroid hormone, in which at least one of the amino acid residues at positions 7, 11, 23, 24, 27, 28, and 31 is cyclohexylalanine, or at least one of the amino acid residues at positions 3, 16, 17, 18, 19, and 34 is .alpha.-aminoisobutyric acid; or, alternatively, at least the amino acid residue at position 1 is .alpha.,.beta.-diaminopropionic acid, the amino acid residue at position 27 is homoarginine, or the amino acid residue at position 31 is norleucine.
Abstract: The present invention is directed to a method of using somatostatin or a somatostatin agonist to inhibit the proliferation of Helicobacter pylori (H. pylori), which comprises administering to a patient in need thereof an effective amount of said somatostatin or somatostatin agonist. Preferably, a somatostatin sub-type receptor 2 (SSTR-2) selective somatostatin agonist is administered in a method of this invention. The inhibition of H. pylori proliferation is useful in treating various gastroduodenal diseases such as peptic ulcers, gastric cancer and gastric lymphoma.
Type:
Grant
Filed:
May 7, 1998
Date of Patent:
October 19, 1999
Assignee:
Biomeasure, Incorporated
Inventors:
Hiroshi Kaneko, Terunori Mitsuma, Koichi Yamashita, Barry Morgan
Abstract: Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.
Type:
Grant
Filed:
June 2, 1997
Date of Patent:
January 26, 1999
Assignee:
Kinerton Limited
Inventors:
Shalaby W. Shalaby, Steven A. Jackson, Jacques-Pierre Moreau
Abstract: Pure nucleic acids encoding novel receptors for bombesin-like peptides, the novel receptors themselves, and their antibodies. Also disclosed is a method of screening for a compound capable of interacting with any of these novel receptors.
Type:
Grant
Filed:
August 12, 1997
Date of Patent:
September 29, 1998
Assignee:
The Medical Research Foundation of Oregon
Inventors:
Eliot R. Spindel, Srinivasa Nagalla, Brenda Barry
Abstract: A method of promoting bone formation in a human patient, which includes the step of administering continuously to the patient parathyroid hormone or its agonist for a period of at least one month at a dosage between 10 and 400 units/24 hrs. Also disclosed are novel parathyroid hormone agonists.