Abstract: The invention relates to compositions useful for making taste-masked oral dosage forms which can be easily processed and which disintegrate rapidly when placed in the mouth. The compositions include coated liquiflash particles and shearform floss particles. Tablets are preferred dosage forms.
Type:
Grant
Filed:
October 30, 1998
Date of Patent:
December 26, 2000
Assignee:
Fuisz Technologies Ltd.
Inventors:
Djelila Mezaache, Michael G. Raiden, Pradeepkumar P. Sanghvi, Scott J. Szedlock
Abstract: The present invention is a new mesomorphic polycrystallite product and a process for making the same. In the present invention amorphous sugar is transformed to a mesomorphic product having polycrystallites therein by a completely anhydrous process rather than by hydrating and then dehydrating the sugar. The product of the present invention is unique in shape and size, and possesses a high degree of uniformity. The properties of the polycrystallite make it possible to replace some or all of the fat in comestibles such as frostings and fillings and to provide fondants of extraordinarily fine grain.
Type:
Grant
Filed:
August 12, 1997
Date of Patent:
October 17, 2000
Assignee:
Fuisz Technologies Ltd
Inventors:
Subraman R. Cherukuri, Jose F. Zamudio-Tena, Robert K. Yang, Andrea S. Blake, Paul M. Croushorn
Abstract: A method of producing a solid thermoplastic-containing matrix by flash flow processing thermoplastic polymers as well as the products produced by such method is provided. The method involves subjecting a feedstock of a thermoplastic polymer to flash flow melt spin processing at a temperature of about 200-430.degree. F. and shear imposed by centrifugal force from an operating speed of about 3600-3800 rpm. The matrix thus prepared is in the form of a floss, fiber, flake, filament, ribbon, spicule and mixtures thereof A guest material such as a dye, a fragrance, a comestible, an oil, a photographic reducer and developer, an organism, an antioxidant and a medicament may further be incorporated into the feedstock prior to processing.
Abstract: A spinner head provides for the production of melt-spun product. The spinner head includes a base and a cover spaced from the base. A plurality of discrete spaced apart elongate heating elements are positioned between the base and the cover and define a chamber for accommodating feedstock material therein. An elongate generally annular housing having plural circumferentially spaced cylindrical passages extending therethrough is positionable over the heating elements. The housing defines a plurality of circumferentially spaced fins projecting radially inward. Each of the fins have tapered sidewalls which generally converge as the fin extends radially inward. The sidewalls of adjacent fins cooperate to define longitudinal radially-directed slots between the cylindrical passages so as to permit passage of the feedstock material therethrough.
Type:
Grant
Filed:
July 10, 1998
Date of Patent:
September 12, 2000
Assignee:
Fuisz Technologies Ltd.
Inventors:
Beuford A. Bogue, Mesfin B. Abdi, Claude Bayard, Robert A. Madsen, James H. Perkins
Abstract: The invention relates to compositions useful for making tablets which can be formed using conventional tableting machines and which disintegrate rapidly in the mouth with optional chewing. The compositions typically include shearform matrices which have been recrystallized using crystallization promoters.
Type:
Grant
Filed:
August 12, 1998
Date of Patent:
April 11, 2000
Assignee:
Fuisz Technologies Ltd.
Inventors:
Tushar K. Misra, Jeffery W. Currington, Barbara Montwill, Satish V. Kamath, Pradeepkumar P. Sanghvi, John R. Sisak, Michael Raiden
Abstract: A composition and method for preparing multi-vitamin comestible units which disperse quickly in the mouth, especially when chewed, includes initiating crystallization of shearform matrix with crystallization/binding promoter and combining with an additive to form flowable, compactible micro-particulates. The combination is then shaped to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.
Type:
Grant
Filed:
June 19, 1998
Date of Patent:
October 12, 1999
Assignee:
Fuisz Technologies Ltd.
Inventors:
Richard C. Fuisz, Subraman R. Cherukuri, Suresh B. Kota, James L. Stewart
Abstract: A material processing apparatus and method for processing a solid feedstock material through a melt spin process including a spinner head having a spinner head chamber defined by a parametrical processing wall through which the solid feedstock material is processed. The apparatus includes a device for rotating the spinner head about an axis of rotation to cause the feedstock material to be repelled towards and through the processing walls. A heating source separate from and exterior to the spinner head is included for heating the feedstock material to an elevated temperature to cause the melt spin processing as the feedstock material is projected through the processing wall.
Type:
Grant
Filed:
November 7, 1997
Date of Patent:
August 17, 1999
Assignee:
Fuisz Technologies Ltd.
Inventors:
B. Arlie Bogue, Steven E. Frisbee, William F. Rutkowski
Abstract: The present invention provides consumable, gummy delivery systems and methods of making the same. The gummy delivery systems include an active ingredient admixed with a glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin and glycerin to a temperature and for a time sufficient to remove some of the moisture content of the initial aqueous solution. The active ingredient can be delivered from a shearform matrix carrier.
Abstract: The present invention is a new mesomorphic polycrystallite product and a process for making the same. In the present invention amorphous sugar is transformed to a mesomorphic product having polycrystallites therein by a completely anhydrous process rather than by hydrating and then dehydrating the sugar. The product of the present invention is unique in shape and size, and possesses a high degree of uniformity. The properties of the polycrystallite make it possible to replace some or all of the fat in comestibles such as frostings and fillings and to provide fondants of extraordinarily fine grain.
Type:
Grant
Filed:
August 12, 1997
Date of Patent:
March 2, 1999
Assignee:
Fuisz Technologies Ltd.
Inventors:
Subraman R. Cherukuri, Jose F. Zamudio-Tena, Robert K. Yang, Garry L. Myers, Andrea S. Blake, Paul M. Croushorn
Abstract: The present invention is a comestible composition including a new spheroidal polycrystallite product. In the present invention amorphous sugar is transformed to crystalline sugar by hydrating rather than dehydrating sugar.
Type:
Grant
Filed:
December 1, 1997
Date of Patent:
February 2, 1999
Assignee:
Fuisz Technologies Ltd.
Inventors:
Gerald E. Battist, Garry L. Myers, Richard C. Fuisz
Abstract: A spinner head provides for the production of high fat content floss. The spinner head includes a base and a cover spaced from the base. A plurality of discrete spaced apart elongate heating elements are positioned between the base and the cover and define a chamber for accommodating feedstock material therein. The chamber is spun and the feedstock material is heated and is expelled through the spaces between the heating elements. Feedstock engagement surfaces are positioned in alignment with each of the spaces between the heating elements so as to engage the expelled feedstock to alter the direction of travel of the expelled product.
Type:
Grant
Filed:
May 12, 1997
Date of Patent:
November 10, 1998
Assignee:
Fuisz Technologies Ltd.
Inventors:
Mesfin Abdi, Claude Bayard, James H. Perkins
Abstract: The present invention is a new fondant product including spheroidal polycrystallite structures or monodispersed sugar crystallites released from the polycrystallite structures.
Type:
Grant
Filed:
January 13, 1997
Date of Patent:
October 27, 1998
Assignee:
Fuisz Technologies Ltd.
Inventors:
Gerald E. Battist, Garry L. Myers, Richard C. Fuisz
Abstract: The present invention is a new method of making a confectionery mass, such as a nougat, by hydrating sufficiently to form the mass without the need for cooking to drive off moisture. The present invention also includes a product prepared by positively hydrating a mixture of confectionery ingredients including a hydrobinding component and shearform product.
Type:
Grant
Filed:
December 20, 1996
Date of Patent:
September 8, 1998
Assignee:
Fuisz Technologies Ltd.
Inventors:
Subraman R. Cherukuri, Robert K. Yang, Cecil A. Bowles, Jose F. Zamudio-Tena, Santi R. Bhowmik
Abstract: The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.-2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided.Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality.Q--(S--PO.sub.3 .sup.-2)n (I)The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C.sub.1 -C.sub.5 alkyl and CONH(CH.sub.2)p wherein p is an integer between 1 and 5.
Type:
Grant
Filed:
May 29, 1996
Date of Patent:
August 4, 1998
Assignee:
Abbott Laboratories
Inventors:
Christopher Bieniarz, Douglas F. Young, Michael J. Cornwell, Mazhar Husain, Zbigniew Skrzypczynski
Abstract: 5(6)-methyl substituted fluorescein derivatives and a process for producing 5(6)-methyl substituted derivatives. Also provided are methods for these utilizing these derivatives as indicator reagents in assays for analytes, indicator reagents which comprise specific binding members attached to these derivatives and test kits which contain these derivatives.
Abstract: Cyclosporine derivatives useful as detectable tracer compounds for the immunoassay determination of cyclosporine are disclosed. The cyclosporine derivatives comprise a detectable moiety coupled to the amino acid at the first position (MeBmt) in cyclosporine, the second position (Abu) in cyclosporine, the third position (Sar) in cyclosporine, the eighth position (D-Ala) in cyclosporine, or the tenth position (MeLeu) in cyclosporine. A preferred cyclosporine derivative comprises a fluorescent moiety coupled to the hydroxyl group of the amino acid at the first position in cyclosporine, and is especially useful for the fluorescent polarization immunoassay determination of cyclosporine. A fluorescent polarization immunoassay method and test kit are also disclosed.
Type:
Grant
Filed:
May 4, 1995
Date of Patent:
May 12, 1998
Assignee:
Abbott Laboratories
Inventors:
Marjorie A. Morrison, Steven E. Lunetta, Victoria P. Meucci, Mariola B. Zajac, Elizabeth A. Simpson
Abstract: Solid delivery systems for highly volatile flavor oils which include a stabilized, substantially non-volatile mixture of a highly volatile flavor oil or flavor component and a medium chain triglyceride are disclosed. The stabilized mixtures may be absorbed or adsorbed onto a non-fat solid substrate and incorporated into a saccharide based matrix and flash flow processed. The delivery systems may be added to chewing gum and confectionery products, as well as other pharmaceutical and comestible preparations.
Type:
Grant
Filed:
October 23, 1996
Date of Patent:
April 28, 1998
Assignee:
Fuisz Technologies Ltd.
Inventors:
Subraman R. Cherukuri, Gerald E. Battist, Jose F. Zamudio-Tena