Abstract: A process for treating adult respiratory distress syndrome by the systemic administration of flurbiprofen (3-fluoro-4-phenylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.

Abstract: A process for treating the blood-brain barrier by the systemic administration of ibuprofen (p-isobutylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.

Abstract: A process for treating the blood-brain barrier by the systemic administration of flurbiprofen (3-fluoro-4-phenylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.

Abstract: This invention relates to the new use of a known polymeric material for the neutralizing of gastric acidity and treating hyperacidity in humans having an excess of gastric acidity and the treatment of ulcers. The polymeric material is a copolymer of polyethylenepolyamine and a bifunctional substance. Oral pharmaceutical dosage forms and doses are shown.

Abstract: Therapeutic compositions for treating humans and animals comprising, in dosage unit form, a 1-hydroxymethyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine compound of the formula: ##STR1## including the N-oxides esters and pharmacologically acceptable acid addition salts thereof in combination with a pharmaceutical carrier. The compositions are useful as soporifics and provide a process for inducing sleep.

Abstract: Novel pesticidal N-[[[arylformimidoyl]methylamino]thio]-N-substituted sulfonamides are disclosed with novel compositions thereof and methods for their use in controlling invertebrate arthropod pests, particularly insects, mites, and ticks.

Abstract: A process for increasing productivity in healthy animals comprising the administration of a compound of the formula ##STR1## in association with the animal feed water or salt rations. Compositions comprising a compound of the above formula for daily administration or long acting forms are disclosed.

Abstract: A process for increased productivity in healthy animals comprising the administration of a compound of the formula ##STR1## or a pharmacologically acceptable acid addition salt thereof wherein R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of lower alkyl of from 1 to 4 carbon atoms; R.sub.3 and R.sub.4 are the same or different and are selected from the group consisting of hydrogen, halogen, and lower alkyl of from 1 to 4 carbon atoms, and n is 1 or 2 provided that when n is 2 then R.sub.1 and R.sub.2 are the same and R.sub.3 and R.sub.4 are the same, in association with the animal feed, water, salt rations, or pharmacologically acceptable carrier. Compositions comprising a compound of the above formula for daily administration or long acting forms are disclosed.

Abstract: A process for increasing productivity in healthy animals comprising the administration of a compound of the formula ##STR1## wherein X and Y, which may be identical or different, are 2,3-dimethylphenyl, 2,4-dimethylphenyl, 2,6-dimethylphenyl, 2,4,6-trimethylphenyl, 2,4,5-trimethylphenyl, 2,3,4-trimethylphenyl, 2-methyl-4-halophenyl, 2-ethyl-4-halophenyl, 2-halo-4-methylphenyl, 2-halo-4,6-dimethylphenyl, 2,4-dihalo-6-methylphenyl, 2-methyl-4-methoxyphenyl, phenyl or methyl-phenyl, provided that (a) when X and Y are identical, they are not phenyl or methylphenyl and (b) when X and Y are different, at least one of them is 2,3-dimethylphenyl, 2,4-dimethylphenyl, 2,4,6-trimethylphenyl, 2,3,4-trimethylphenyl, 2-methyl-4-halophenyl or 2-halo-4-methylphenyl or a pharmacologically acceptable acid addition salt thereof in association with the animal's feed, water, salt ration, or pharmacologically acceptable carrier.

Abstract: A process for increased productivity in healthy animals comprising the administration of a compound of the formula ##STR1## or a pharmacologically acceptable acid addition salt thereof, wherein R.sub.1 is lower alkyl of from 1 to 4 carbon atoms; R.sub.2 is hydrogen, halogen, or lower alkyl of from 1 to 4 carbon atoms; R.sub.3 and R.sub.4 are the same or different and are hydrogen, alkyl of 1 to 8 carbon atoms, inclusive; haloalkyl, arylalkyl and ##STR2## wherein alkyl is from 1 to 4 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, or aryl, and R.sub.3 and R.sub.4 taken together with --N.dbd.are a member selected from the group piperidine, morpholine, pyrazole, tribromopyrazole, N-methylpiperazine, pyrrole, pyrrolidine, pyrrolidone in association with the animal's feed, water, salt ration, or pharmacologically acceptable carrier. Compositions comprising a compound of the above formula for daily administration or long acting forms are disclosed.

Abstract: A process for increased productivity in healthy animals comprising the administration of a compound of the formula: ##STR1## or a pharmacologically acceptable acid addition salt thereof wherein R.sub.1 is lower alkyl of from 1 to 4 carbon atoms, inclusive, R.sub.2 is selected from hydrogen, halogen and lower alkyl of from 1 to 4 carbon atoms, inclusive, and R.sub.3 is selected from lower alkyl of from 1 to 4 carbon atoms, inclusive, phenyl, halogen-substituted phenyl, lower alkyl of from 1 to 4 carbon atoms, inclusive, -substituted phenyl, lower alkoxy of from 1 to 4 carbon atoms, -substituted phenyl and halogen-substituted lower alkyl of from 1 to 4 carbon atoms, inclusive, in association with the animal feed, water, salt rations, or pharmacologically acceptable carrier. Compositions comprising a compound of the above formula for daily administration or long acting forms are disclosed.

Abstract: A process for increased productivity in healthy animals comprising the administration of a compound of the formula ##STR1## or a pharmacologically acceptable acid addition salt thereof wherein R.sub.1 is chloro, bromo, or alkyl of 1 through 4 carbon atoms; R.sub.2 is hydrogen, chloro, bromo, or alkyl of 1 through 4 carbon atoms; R.sub.3 is (1) alkyl of 1 through 8 carbon atoms, (2) cycloalkyl of 5 through 8 carbon atoms, (3) phenalky wherein alkyl is 1 or 2 methylene units in length, or (4) phenyl where the phenyl is unsubstituted or substituted with 1 through 3 substituents selected from the group consisting of methyl, chloro, bromo, nitro, trifluoromethyl, alkoxy of 1 or 2 carbon atoms, and cyano, and R.sub.

Abstract: A process for preventing a reducing adhesion formation by the systemic administration of ibuprofen (p-isobutylhydratropic acid) or a salt or ester thereof. Dosage forms are also desirable.

Abstract: A process for increasing production in meat-producing, egg-laying or milk-producing animals comprising feeding a compound of the formula: ##STR1## wherein R.sub.1 is a member selected from the group consisting of alkyl of from 1 to 8 carbon atoms, inclusive, including isomeric forms thereof, R.sub.2 and R.sub.3 are the same or different and are a member selected from the group consisting of hydrogen, provided that both R.sub.2 and R.sub.3 are not hydrogen; alkyl of from 1 to 8 carbons, inclusive, including isomeric forms thereof, cycloalkyl of from 3 to 8 carbona toms, alkyl substituted cycloalkyl of the formula ##STR2## wherein n is an integer of from 2 to 7, inclusive, and R.sub.

Abstract: A process for increasing production in meat-producing, egg-laying or milk-producing animals comprising feeding a compound of the formula: ##STR1## wherein R is a member selected from the group consisting of hydrogen, R.sub.4 wherein R.sub.4 is alkyl of from 1 to 8 carbon atoms, inclusive, including isomeric forms thereof, alkenyl of from 2 to 8 carbon atoms, inclusive, including isomeric forms thereof, cycloalkyl of from 3 to 7 carbon atoms, ##STR2## and acyl wherein acyl is up to and including five carbon atoms. R.sub.1 is a member selected from the group consisting of hydrogen, R.sub.4, and ##STR3## wherein R.sub.5 is selected from the group consisting of hydrogen; ##STR4## and acyl wherein acyl is up to and including five carbon atoms; R.sub.2 and R.sub.3 are the same or different and are a member selected from the group consisting of hydrogen, provided that both R.sub.2 and R.sub.3 are not hydrogen; R.sub.

Abstract: A process for treating hypertension comprising the systemic administering to a hypertensive subject a compound of the formula: ##STR1## wherein R.sub.1 is --NH.sub.2.R.sub.2 is chloro, bromo, or iodo.R.sub.3 is hydrogen or fluorine.R.sub.4 is hydrogen or fluorine, andR.sub.5 is hydrogen, fluorine, or CH.sub.3 ; or the salts thereof in association with a pharmaceutical carrier.

Abstract: A process for increasing production in meat-producing, egg-laying or milk-producing animals comprising feeding a compound of the formula: ##STR1## wherein R is a member selected from the group consisting of hydrogen, R.sub.5, ##STR2## wherein R.sub.5 is alkyl of from 1 to 8 carbon atoms, inclusive, including isomeric forms thereof; alkenyl of from 2 to 8 carbons, inclusive, including isomeric forms thereof, cycloalkyl of from 3 to 7 carbon atoms; or R is lower acyl wherein acyl is up to and including 5 carbon atoms; R.sub.1 is a member selected from the group consisting of R.sub.5 and ##STR3## wherein R.sub.6 is selected from the group consisting of hydrogen, ##STR4## or lower acyl wherein acyl is up to and including 5 carbon atoms; R.sub.2 is a member selected from the group consisting of hydrogen, R.sub.5, bromo or chloro; R.sub.3 and R.sub.4 are the same or different and are selected from the group consisting of hydrogen, provided that R.sub.3 and R.sub.4 are not both hydrogen; R.sub.

Abstract: A process for increasing production in meat-producing, egg-laying or milk-producing animals comprising feeding a compound of the formula: ##STR1## wherein R.sub.1 is a member selected from the group consisting of alkyl of from 1 to 8 carbon atoms, inclusive, including isomeric forms thereof, R.sub.2 and R.sub.3 are the same or different and are a member selected from the group consisting of hydrogen, provided that both R.sub.2 and R.sub.3 are not hydrogen; alkyl of from 1 to 8 carbons, inclusive, including isomeric forms thereof, cycloalkyl of from 3 to 8 carbon atoms, alkyl substituted cycloalkyl of the formula ##STR2## wherein n is an integer of from 2 to 7, inclusive, and R.sub.

Abstract: This invention relates to a new method of therapy comprising the administration of a pro-drug to a human or animal, said pro-drug being a compound formed by a therapeutic compound chemically combined with another moiety by a photocleavable bond and irradiating the diseased area with ultraviolet radiation in an amount sufficient to cleave the bond and release the therapeutic compound in a therapeutically effective amount. Specifically disclosed are pro-drugs which are cleaved to therapeutically active medications which are anti-proliferative and anti-inflammatory compounds and the treatment of inflammatory and/or proliferative skin diseases therewith.

Abstract: This invention relates to a new method of therapy comprising the administration of a pro-drug to a human or animal, said pro-drug being a compound formed by a therapeutic compound chemically combined with another moiety by a photocleavable bond and irradiating the diseased area with ultraviolet radiation in an amount sufficient to cleave the bond and release the therapeutic compound in a therapeutically effective amount. Specifically disclosed are pro-drugs which are cleaved to therapeutically active medications which are anti-proliferative and anti-inflammatory compounds and the treatment of inflammatory and/or proliferative skin diseases therewith.