Abstract: This invention relates to a method of increasing the dispersibility and mixability of psyllium hydrophilic mucilloid by applying a film of hydrolyzed starch oligosaccharide, a mono-or di-saccharide, a polyglucose, or a polymaltose.
Type:
Grant
Filed:
July 5, 1983
Date of Patent:
October 22, 1985
Assignee:
G. D. Searle & Co.
Inventors:
John A. Colliopoulos, David B. Paul, James G. Young
Abstract: A therapeutically effective amount of isotretinoin is co-administered to patients suffering from severe cystic acne with a protective amount of taurine which reduces the side effects of isotretinoin.
Abstract: This invention relates to substituted chromanon-2-yl alkanols and derivatives thereof, which are useful as leukotriene D.sub.4 (LTD.sub.4) inhibitors and therefore useful in the treatment of allergies, inflammatory conditions, and coronary vasoconstriction.
Type:
Grant
Filed:
May 29, 1984
Date of Patent:
October 8, 1985
Assignee:
G. D. Searle & Co.
Inventors:
Masateru Miyano, Clara I. Villamil, Robert L. Shone
Abstract: The present invention encompasses 16-alkyl, 16-hydroxy-2-substituted prostaglandins which exhibit cytoprotective and antisecretory activity with greatly reduced diarrhea side effects.
Type:
Grant
Filed:
February 16, 1984
Date of Patent:
August 20, 1985
Assignee:
G. D. Searle & Co.
Inventors:
Paul W. Collins, Alan F. Gasiecki, Richard M. Weier
Abstract: An improved process for isolating organic compounds from crude product or reaction mixtures by dissolving said crude product or reaction mixture in a suitable solvent, contacting the resulting solution with a lithium salt to form a solid metal salt complex, separating, and thereafter recovering a pure product by decomposing the lithium salt complex.
Abstract: This invention relates to novel 3-oxa-15-desoxy-16-hydroxy-16-alkyl prostaglandins of the E.sub.2 series and the 5,6-acetylene derivatives thereof. These compounds are useful for their gastric antisecretory, cytoprotective, antiulcer, and antihypertensive activity. In addition the invention also discloses certain novel trialkylsilyl acetylenic intermediates.
Abstract: This invention relates to novel substituted 2-(3-aminophenoxymethyl)imidazolines which are useful for the treatment of diarrhea and useful as analgesics.
Type:
Grant
Filed:
November 10, 1983
Date of Patent:
June 11, 1985
Assignee:
G. D. Searle & Co.
Inventors:
Alan E. Moormann, Barnett S. Pitzele, Peter H. Jones
Abstract: This invention relates to novel compounds for preventing or retarding the degradation of elastin or other proteins and therefore preventing or retarding the disease states caused by said degradation, of the formula: ##STR1## or its pharmacologically acceptable salts. The invention also relates to novel methods and intermediates for making the compounds. The intermediate compound being of the formula: ##STR2## wherein R.sub.2 is (a) halogen; or(b) trifluoromethyl;wherein R.sub.3 is(a) --C(O)R.sub.4 ;(b) --CH(OH)R.sub.4 ;(c) --CH.sub.2 R 4; or(d) --CH.dbd.CHR.sub.4 ;wherein R.sub.4 is alkyl or 13 to 25 carbon atoms inclusive, and the pharmacologically acceptable base addition salts thereof.
Abstract: This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds of the formula: ##STR1## or their pharmacologically acceptable salts.
Abstract: This invention encompasses prostaglandins of the formula I ##STR1## wherein R'" represents hydroxymethyl, hydroxyacetyl or --CO.sub.2 R"" wherein R"" represents hydrogen or lower alkyl containing 1 to 6 carbon atoms;R' represents lower alkyl containing 1 to 6 carbon atoms, vinyl or ethynyl;R" represents cycloalkyl containing 3 to 5 carbon atoms; and the wavy line represents optional R,S stereochemistry.These compounds are potent antisecretory compounds and cytoprotective agents with reduced diarrhea side effects.
Abstract: This invention relates to novel diastereomeric 7-O-(substituted acetyl)-4-demethoxydaunomycinones that are useful in the preparation of optically pure 4-demethoxydaunorubicin, a drug used in the treatment of certain cancers.
Abstract: This invention encompasses a method and intermediates for preparing a commercial sweetening agent, .alpha.-L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydride by reaction with acetic anhydride. N-acetoacetyl-L-aspartic anhydride is reacted with L-phenylalanine methyl ester to provide N-acetoacetyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester which is converted to .alpha.-L-aspartyl-L-phenylalanine methyl ester by reaction with hydroxylamine hydrochloride.
Abstract: The present invention relates to a method for promoting weight gain in a domestic farm animal which comprises subcutaneously implanting a slow-release implant which contains norgestomet in a quantity such that at least 75 mcg/day to a maximum of 200 mcg/day is administered for a period of from 60 to 210 days.
Abstract: This invention relates to novel compounds for preventing or retarding the degradation of elastin or other proteins and therefore preventing or retarding the disease states caused by said degradation, of the formula: ##STR1## or its pharmacologically acceptable salts. The invention also relates to novel methods and intermediates for making the compounds.