Patents Represented by Attorney John J. McDonnell
  • Patent number: 4053580
    Abstract: The present invention is concerned with a pharmaceutical delivery device comprising a biologically acceptable silicone polymer matrix having microsealed compartments of 10-200 microns throughout, wherein the microsealed compartments contain a pharmaceutical in a hydrophilic solvent system. The biologically acceptable silicone polymer matrix is formed by in situ cross linking of a liquid, biologically acceptable silicone polymer in an emulsion of pharmaceutical in the hydrophilic solvent system and liquid biologically acceptable silicone polymer. The biologically acceptable silicone polymer matrix is placed in a sealed or unsealed biologically acceptable polymer container.
    Type: Grant
    Filed: September 20, 1976
    Date of Patent: October 11, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Yie W. Chien, Howard J. Lambert
  • Patent number: 4048335
    Abstract: 1-(N-isopropyl-N,N-dimethylamino)-3-(1-naphthoxy)propan-2-ol quaternary salts are useful cardiovascular agents as evidenced by their potent and long-acting anti-arrhythmic, anti-fibrillatory and myocardial ischemia-inhibitory activity. They, furthermore, lack the undesirable side-effects, e.g. .beta.-adrenergic receptor blocking and local anesthetic activity, characteristic of related prior art compounds.
    Type: Grant
    Filed: August 19, 1976
    Date of Patent: September 13, 1977
    Assignee: The Regents of the University of Michigan
    Inventor: Benedict R. Lucchesi
  • Patent number: 4048202
    Abstract: 3-O-Alkanoylglyceric acids and their salts having antimicrobial properties are described herein. These compounds also have useful surfactant properties. The subject compounds can be prepared by reacting the appropriate acid chloride with glyceric acid.
    Type: Grant
    Filed: April 11, 1975
    Date of Patent: September 13, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Charles I. Beck, Roger M. Layton
  • Patent number: 4046722
    Abstract: The present invention is concerned with a cytotoxic agent comprising an immunoglobulin specific for antigens on the surface of the cell to be killed having 1-10 polymer carrier molecules covalently bonded thereto and the polymer carrier having 5-500 molecules of a cytotoxic drug covalently bound. The compounds of the present invention are useful as anti tumor agents.
    Type: Grant
    Filed: January 14, 1976
    Date of Patent: September 6, 1977
    Assignee: G. D. Searle & Co. Limited
    Inventor: George Ferdinand Rowland
  • Patent number: 4045442
    Abstract: The reaction of 1-(halo/cyano/sulfonyloxy)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazin es with an amine affords the corresponding 1-(substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines which compounds are useful anti-inflammatory or anti-diarrheal agents.
    Type: Grant
    Filed: January 5, 1976
    Date of Patent: August 30, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Richard A. Mueller
  • Patent number: 4038139
    Abstract: The present invention relates to culture media in which animal cells may be grown and more particularly to such culture media containing animal serum and methods for culturing cells in the media. Specifically, the present invention encompasses a culture medium for lymphoblast cells comprising an aqueous nutrient medium containing 0.5% - 20% swine serum and about 0.1% of a surfactant which inhibits the precipitation of proteins and methods for using said medium.
    Type: Grant
    Filed: July 16, 1976
    Date of Patent: July 26, 1977
    Assignee: G. D. Searle & Co., Limited
    Inventor: John R. Birch
  • Patent number: 4034081
    Abstract: Vaccines affording protection against the diseases resulting from infection of cats with feline leukemia virus are produced from cells infected with that virus or from the virus alone.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: July 5, 1977
    Assignee: University of Glasgow
    Inventors: William Fleming Hoggan Jarrett, James Oswald Jarrett, Lindsay Joan Mackey
  • Patent number: 4032645
    Abstract: An injectable solution suitable for the systemic treatment of anaerobic infections is prepared by solubilization of 500-650 mg. metronidazole in 10 ml. of a solvent system comprised of:25-35% v/v N,N-dimethylacetamide40-60% v/v ethanol10-30% v/v aqueous bufferOr,15-25% v/v N,N-dimethylacetamide40-60% v/v ethanol10-30% v/v aqueous bufferAnd including one of the following:1-5% v/v nicotinamide5-15% v/v propylene glycol5-15% v/v 2,2-dimethyl-1,3-dioxolane-4-methanol,The aqueous buffer maintaining the pH at 5.0-7.5.
    Type: Grant
    Filed: June 19, 1975
    Date of Patent: June 28, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Yie W. Chien, Dianne M. Jefferson
  • Patent number: 4032408
    Abstract: The present invention is concerned with the preparation of 3-oxo-pregna-4,17(20)-dien-21-carboxylic acid and esters thereof by the microbial degradation of fucosterol, cholesterol, stigmasterol, campesterol or sitosterol with Mycobacterium sp. NRRL B-8054. The compounds of the present invention are useful antispasmodic agents and are also active against influenza virus.
    Type: Grant
    Filed: August 4, 1976
    Date of Patent: June 28, 1977
    Assignee: G. D. Searle & Co.
    Inventors: James Jiu, William J. Marsheck
  • Patent number: 4029727
    Abstract: A new method for producing high-strength films, fibers and other shaped articles from chitin has been discovered, whereby an anhydrous solution of chitin is made into the desired shape, the chitin is insolubilized with an organic non-solvent for the chitin and the resultant shaped article, if desired, is oriented, by cold drawing until its properties, such as tensile strength, are substantially enhanced. The films, fibers, and other shaped articles capable of being oriented or in oriented form, are novel and useful in such applications as food wrap and surgical sutures.
    Type: Grant
    Filed: April 16, 1975
    Date of Patent: June 14, 1977
    Assignee: The University of Delaware
    Inventors: Paul Roland Austin, Charles James Brine
  • Patent number: 4029689
    Abstract: The above-captioned compounds display anti-microbial activity, e.g. anti-bacterial and anti-fungal, and are, in addition, useful as intermediates in the manufacture of prostanoic acid derivatives.
    Type: Grant
    Filed: March 21, 1975
    Date of Patent: June 14, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Mildred S. Bruhn, Raphael Pappo
  • Patent number: 4028319
    Abstract: Analogs of enkephalin having agonist activity at opiate receptors are disclosed herein. These analogs are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.
    Type: Grant
    Filed: May 7, 1976
    Date of Patent: June 7, 1977
    Assignee: G. D. Searle & Co.
    Inventors: David A. Jones, Jr., James M. Schlatter, Richard A. Mikulec, Judith A. Reuter, Robert H. Mazur
  • Patent number: 4025551
    Abstract: 3-Amino-N-substituted succinamic acids, prepared by coupling of a protected L-aspartic acid derivative with the appropriate amine followed by cleavage of the protecting groups, are potent sweetening agents and also exhibit pharmacological, e.g. anti-inflammatory, properties.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: May 24, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Arthur H. Goldkamp, Robert H. Mazur, James M. Schlatter
  • Patent number: 4024290
    Abstract: The present invention encompasses a bulking agent suitable for incorporating into formulated foods. The bulking agent of the present invention is prepared by condensation of glucose and sorbitol in the presence of an acid-ion exchange resin. The bulking agent of the present invention provides the functions and bulk of about the same weight of sucrose when incorporated into formulated foods. The bulking agent of the present invention is most advantageously used in conjunction with high intensity sweeteners.
    Type: Grant
    Filed: March 22, 1976
    Date of Patent: May 17, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Roger M. Layton
  • Patent number: 4021305
    Abstract: The present invention is concerned with a string culture inoculum comprising a string having stabilized cells of one of______________________________________ Salmonella typhimurium ATCC 6994 Klebsiella pneumoniae ATCC 10031 Enterobacter cloacae ATCC 11367 Escherichia coli ATCC 25922 Citrobacter freundii ATCC 6750 Proteus vulgaris ATCC 881 Pseudomonas aeruginosa ATCC 15442 Shigella sonnei ATCC 11060 Serratia marcescens ATCC 14756 Staphylococcus aureus ATCC 25923 Staphylococcus epidermidis ATCC 17917 Streptococcus faicalis ATCC 10541 Streptococcus pyogenes ATCC 12202 ______________________________________dispersed throughout, said string culture inoculum having a sufficient number of stabilized cells adhered thereto to produce at least 10.sup.5 cells per milliliter upon incubation in 3 milliliters of suitable broth at 37.degree. C. for 2 hours.
    Type: Grant
    Filed: May 19, 1976
    Date of Patent: May 3, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Robert D. Muir, Vijay K. Sangar
  • Patent number: 4017471
    Abstract: The present invention relates to an antitumor agent comprising p-di(2-chloroethyl)amino-L-phenylalanine or N,N-bis(2-chloroethyl)p-phenylenediamine hydrochloride bound to a tumor specific antibody by peptide bonds. The antitumor agent of the present invention is prepared by reacting a cytotoxic agent, p-di(2-chloroethyl)amino-L-phenylalanine or N,N-bis(2-chloroethyl)p-phenylenediamine hydrochloride with a tumor specific antibody in the presence of a water soluble carbodiimide such as 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and thereby forming a peptide bond between the cytotoxic agent and the tumor specific antibody.
    Type: Grant
    Filed: September 15, 1975
    Date of Patent: April 12, 1977
    Assignee: G. D. Searle & Co.
    Inventor: David Allen Lewis Davies
  • Patent number: 4017491
    Abstract: The present invention relates to compounds of the following formula ##STR1## wherein Y is straight or branched chain alkylene containing 1-4 carbon atoms; X is hydrogen, halo such as fluoro, chloro, bromo or iodo, or lower alkyl containing 1-7 carbon atoms; Ar is phenyl, pyridyl, mono-substituted phenyl, wherein the substituent is halo such as fluoro, chloro, or bromo, or lower alkyl having 1-7 carbon atoms; and R.sub.2 and R.sub.3 are lower alkyl having 1-7 carbon atoms, or R.sub.2 and R.sub.3 together with N is an azamonocyclic ring selected from the group comprising 1-pyrrolidinyl, piperidino, 4-phenyl-4-hydroxypiperidino, 4-phenyl-4-hydroxymethylene, 4-phenyl-4-carboxypiperidino, 4-phenyl-4-carbloweralkoxypiperidino, or 4-phenyl-4-acetoxypiperidino substituted piperidino and morpholino, or an azabicycloalkanyl containing 6 to 9 carbon atoms and having at least 5 atoms in each ring of the azabicycloalkane. These compounds are useful intermediates for preparing potent antidiarrheal compounds.
    Type: Grant
    Filed: July 28, 1975
    Date of Patent: April 12, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Gilbert W. Adelstein
  • Patent number: 4017644
    Abstract: The present invention concerns a high calorie food bar essentially devoid of sodium, potassium, and protein comprising a baked dough having 150-250 parts by weight of pregelatinized starch which has a viscosity in water of 250-500 Brabender units, 300-500 parts by weight of edible vegetable oil, 200-400 parts by weight sugar, and consumable coloring and flavoring. Unexpectedly the oil in this high calorie food bar does not separate or oil out upon baking. The high calorie food bar of the present invention is a tasty, appetizing and nutritious food for renal and other patients who require a diet high in calories and restricted in sodium, potassium and protein content. The present product contains about 6 calories per gram.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: April 12, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Louis Jokay
  • Patent number: 4012367
    Abstract: This invention encompasses novel tetrapeptide amides and their intermediates containing an L-aspartic acid residue. These peptides are inhibitors of gastric acid secretion and therefore useful in the treatment of ulcers.
    Type: Grant
    Filed: February 5, 1976
    Date of Patent: March 15, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Robert H. Mazur
  • Patent number: 4012391
    Abstract: 11.beta.-Alkyl-2-azaestratrienes, displaying valuable pharmacological properties, e.g. anti-viral and hypolipemic, are manufactured by a total synthesis originating with dihydroresorcinol.
    Type: Grant
    Filed: January 22, 1975
    Date of Patent: March 15, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Robert J. Chorvat, Raphael Pappo