Abstract: Compounds having the structure: ##STR1## wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1' -position of the sugar moiety, provided that when B is purine or 7-deazapurine, it is attached at the N.sup.9 -position of the purine or 7-deazapurine and when B is pyrimidine, it is attached at the N.sup.

Abstract: DNA which encodes the polypeptide streptavidin has been isolated as a fragment 2 kb in length derived from a restriction endonuclease digestion of the chromosomal DNA of Streptomyces avidinii. The nucleic acid sequence of the gene and the amino acid sequence of the polypeptide have been determined. A fused gene has been prepared which comprises the streptavidin gene fused to a gene encoding the human LDL receptor. Expression of the gene fusion results in a fused streptavidin-human LDL receptor polypeptide. Methods are provided for using the fused gene to produce labeled, chemically modified proteins in vivo and to isolate a protein knowing only the nucleotide sequence of the gene encoding the protein.

Abstract: A late differentiation antigen (LDA.sub.1) expressed by activated helper cells is described. LDA.sub.1 is a membrane protein recognized by a monoclonal antibody produced by immunizing mice with an alloreactive human T cell clone with helper function. LDA.sub.1 is expressed by helper T cells optionally 9 days after activation. Anti-LDA.sub.1 monoclonal antibody blocks T cell enhancement of B-cell immunoglobulin production. Thus, LDA.sub.1 is associated with helper T cell effector function. Methods of diagnosis and therapy based upon LDA.sub.1 are also described.

Abstract: Antigen specific excreted transfer factor may be obtained by collecting material, e.g. colostrum or milk, secreted by the mammary gland of a suitable lactating mammal, e.g. a cow having immunity to the antigen under suitable conditions such that materials which interfere with transfer factor efficacy are removed so as to obtain transfer factor. Colostrum or milk so collected may be used directly, typically after sterilization, or may be treated to further concentrate and/or purify transfer factor. Treatment to yield colostral whey containing transfer factor is presently the preferred method for obtaining transfer factor for use in conferring immunity against diseases associated with antigens for which the transfer factor is specific. Cell-associated transfer factor specific for an antigen may also be obtained by incubation release from, or lysis of, cells obtained from the collected material.

Abstract: A process for the solid phase fractionation of sugar cane into three fractions comprising a fibrous fraction derived from the fibrous sclerenchyma cells from the rind of the cane, a fibrous fraction derived from the fibrous sclerenchyma cells of the fibrovascular bundles of the cane and a non-fibrous fraction derived from the parenchyma cells of the cane. The process comprises the steps of (a) subjecting pieces of the cane to a disintegrating force to cause a physical separation of the fibrous sclerenchyma cells from the non-fibrous parenchyma cells, (b) drying the sugar cane material, and (c) separating the sugar cane into the aforementioned three fractions.The dried non-fibrous fraction has utility, inter alia, as an animal feedstuff.

Abstract: A freewheel flywheel transmission system capable of storing and releasing kinetic rotational energy, which includes a shaft rotatively supported by a frame and a plurality of flywheels rigidly mounted on the shaft. The transmission system is provided with an input sprocket for rotating the shaft in response to power transmitted from a power source. A sprocket assembly is mounted on the shaft for transmitting the rotational movement from the flywheels to a drive-wheel sprocket. In one embodiment, power is provided to a freewheel sprocket which rotates the shaft, and thereby the plurality of flywheels. The sprocket assembly includes a first and a second sprocket of different diameters each rotatively supported on bearings on the shaft.