Patents Represented by Attorney John J. Schlager
  • Patent number: 5465458
    Abstract: A retainer for securing towels, garments, papers and the like to railings, fences, ground, etc. comprises two or more weight members spaced or separated by a generally flexible elongated connector which joins them together. Preferably, the weight members will be sac-like or pouch-like receptacles filled with loose pellets and connected together by nylon strap or webbing.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: November 14, 1995
    Inventor: Gary S. Schlager
  • Patent number: 5232829
    Abstract: The present invention relates to the synthesis of amplified biotin-labelled DNA target sequences of Chlamydia trachomatis by polymerase chain reaction techniques and the detection of such sequences by a microtiter plate having plurality of wells and having bound thereto oligonucleotide capture probe complementary to said target sequence.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: August 3, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Mathew Longiaru, Sheryl B. Silver, Michael A. Sulzinski
  • Patent number: 5230828
    Abstract: Optically active dopants of the formula ##STR1## wherein C* denotes a chiral carbon atom and R.sup.1 signifies C.sub.2 -C.sub.12 -alkyl, C.sub.2 -C.sub.12 -alkenyl, C.sub.2 -C.sub.12 -alkoxycarbonyl or C.sub.3 -C.sub.12 -alkenyloxycarbonyl, their manufacture, liquid crystalline mixtures which contain such dopants and their use for optical or electro-optical purposes.
    Type: Grant
    Filed: March 22, 1991
    Date of Patent: July 27, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Stephen Kelly
  • Patent number: 5204018
    Abstract: Compounds of the formula ##STR1## wherein n stands for the number 0 or 1; R.sup.1 denotes a group R.sup.3 or R.sup.3 --A.sup.3 --Z.sup.2 -- and R.sup.2 denotes a group R.sup.4 or R.sup.4 --A.sup.4 --Z.sup.3 --; ring A.sup.1 signifies unsubstituted or halogen-, cyano- and/or methyl-substituted 1,4-phenylene in which optionally 1 CH group or 2 CH groups is/are replaced by nitrogen; A.sup.3, A.sup.4 and ring A.sup.2 each independently represent unsubstituted or halogen-, cyano- and/or methyl-substituted 1,4-phenylene in which optionally 1 CH group or 2 CH groups is/are replaced by nitrogen or trans-1,4-cyclohexylene, trans-1,3-dioxane-2,5-diyl, 1-cyano-trans-1,4-cyclohexylene, bicyclo[2.2.2]octane-1,4-diyl, naphthalene-2,6-diyl, tetralin-2,6-diyl or trans-decalin-2,6-diyl; Z.sup.1, Z.sup.2 and Z.sup.3 each independently signify a single covalent bond, --COO--, --OOC--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.tbd.C--, --(CH.sub.2).sub.3 O--, --O(CH.sub.2).sub.3 --, --(CH.sub.2).sub.4 -- or the trans form of --CH.
    Type: Grant
    Filed: January 22, 1991
    Date of Patent: April 20, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Stephen Kelly
  • Patent number: 5185098
    Abstract: Compounds of formula ##STR1## wherein Z is a single covalent bond or --CH.sub.2 CH.sub.2 --, and R.sup.1 is 1E-alkenyl with 2-12 carbon atoms, liquid crystalline mixtures containing them and their use for electro-optical purposes.
    Type: Grant
    Filed: April 5, 1990
    Date of Patent: February 9, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Buchecker, Martin Schadt, Alois Villiger
  • Patent number: 5185146
    Abstract: The present invention relates to recombinant vaccinia viruses which are derived from the modified virus Ankara (MVA) and which contain a DNA sequence which codes for a foreign antigen. The invention also relates to vaccines which contain a virus of this type in a form suitable for injection, as well as to a method for the preparation thereof. Furthermore, the invention relates to the use of a recombinant vaccinia virus MVA for the preparation of heterologous proteins in eukariotic cells.
    Type: Grant
    Filed: January 4, 1989
    Date of Patent: February 9, 1993
    Assignee: Hoffmann-LaRoche Inc.
    Inventor: Werner Altenburger
  • Patent number: 5096062
    Abstract: A transport system for shipping microbiological specimen samples which maintains the life of the bacteria contained in the sample and protects the environment from escape of samples comprises:(a) a first container provided with removable closure and containing a medium for storing the sample, and(b) a second container provided with a removable closure cap having an elongate chamber into which one end of a rod disposed therein can be pushed, said rod bearing a swab at its other end,the dimensions of the first and second containers, of the chamber in the closure cap and of the rod carrying the swab being so selected that the first container and a rod inserted therein in the medium and carrying the swab can be contained in the second container closed by the closure cap.
    Type: Grant
    Filed: June 19, 1991
    Date of Patent: March 17, 1992
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans-Joachim Burkardt, Wilhelm Weber
  • Patent number: 4980161
    Abstract: There is disclosed a method of treating or preventing viral infections in plants wherein an animal interferon is applied to the plants.
    Type: Grant
    Filed: August 29, 1984
    Date of Patent: December 25, 1990
    Inventor: Ilan Sela
  • Patent number: 4965343
    Abstract: A method for the solid phase synthesis of multi-sulfated peptides comprising coupling side-chain unprotected hydroxyamino acids to the peptide chain utilizing benzotriazol-1-yl-oxy-tris (dimethyl)-phosphonium hexafluorophosphate (BOP) as a coupling reagent.
    Type: Grant
    Filed: January 28, 1988
    Date of Patent: October 23, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur M. Felix, Alain Fournier, Waleed Danho
  • Patent number: 4962044
    Abstract: According to the invention, a piston fit filter/dispenser vial and method of using same is provided. The vial comprises a conventional filter, for example a piston fit serum filter closing the lower end of the vial and a closure having a pressure source fitting closing off the upper end of the vial. The vial also includes a transfer tube having a first end inside the vial adjacent to the filter and a second end outside vial. Filtrate, for example filtered blood serum, within the vial may be transferred in predetermined aliquots to one or more awaiting sample containers from the vial by applying a predetermined volume of air from a pressure source via the pressure source fitting whereby displaced serum is forced up the transfer tube and out of the vial.
    Type: Grant
    Filed: April 25, 1988
    Date of Patent: October 9, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ernest A. Knesel, Jr., Daniel R. Shoemaker, David V. Fansler
  • Patent number: 4957859
    Abstract: Preparation of novel polypeptide sequences spanning amino acid position 61 of the ras protein, said sequences being characterized as containing a leucine in that position instead of the glutamine found in normal ras protein, the utilization of such polypeptides to prepare immunogen compositions utilizing such polypeptide covalently linked to immunogenic carrier materials, the production of antibodies elicited by such polypeptides, the screening of such antibodies to provide monoclonals specific to the P21Tleu61 transforming protein and to immunoassay and use in immunochemical methods employing such antibodies to determine the presence of the p21TLeu61 transforming protein.
    Type: Grant
    Filed: February 16, 1988
    Date of Patent: September 18, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Diane Bizub, Ellyn Fischberg-Bender, Anna M. Skalka
  • Patent number: 4952716
    Abstract: A process for the manufacture of compounds of the general formula ##STR1## wherein R.sup.1 signifies hydroxy or an etherified hydroxy group, and of zeaxanthin by converting a compound of the general formula ##STR2## wherein R.sup.1 has the above significance, in an inert organic solvent into the acetylenide and reacting this with methyl vinyl ketone, reducing the alcoholate obtained or the alcohol (obtained after hydrolysis of the alcoholate) of the general formula ##STR3## wherein R.sup.1 has the above significance, and subsequently hydrolyzing to give the compound of formula IV and, if desired, converting the compound of formula IV obtained into zeaxanthin.
    Type: Grant
    Filed: March 4, 1988
    Date of Patent: August 28, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Teodor Lukac, Milan Soukup
  • Patent number: 3959116
    Abstract: Previously hydroformed feedstocks are upgraded to improve their octane rating by contacting said feedstocks in the presence of hydrogen with a sulfactivated catalyst comprising a metallic hydrogenation component, such as a platinum group metal, in combination with a crystalline aluminosilicate zeolite having uniform pore openings of about 5 Angstrom units. In its more specific aspects, the catalyst further contains a Group II-B metal such as zinc.
    Type: Grant
    Filed: October 15, 1965
    Date of Patent: May 25, 1976
    Assignee: Exxon Research and Engineering Company
    Inventors: William Floyd Arey, Jr., Glen Porter Hamner