Patents Represented by Attorney, Agent or Law Firm John L. Lemanowicz
  • Patent number: 7592352
    Abstract: This invention relates to newly identified compounds for treating and preventing tumors and cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: September 22, 2009
    Assignee: SmithKline Beecham Corporation
    Inventor: Yasushi Miyazaki
  • Patent number: 7582630
    Abstract: The present invention relates to pyrazaolpyradazine derivatives that inhibit GSK3 (glycogen synthase kinase), pharmaceutical compositions containing these derivatives, and methods for their use in the treatment of disorder characterized by misregulation of GSK3.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: September 1, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Scott Howard Dickerson, Francis Xavier Tavares, Huiqiang Zhou
  • Patent number: 7507834
    Abstract: The present invention relates to anilinopyrazole derivatives, methods for the preparation of such anilinopyrazoles, and use of such anilinopyrazoles in the treatment of certain diseases or conditions. In particular, the present invention relates to a nilinopyrazole derivatives useful as CDK2 inhibitors and use of the anilinopyrazoles in the treatment of disorders mediated by inappropriate CDK2 activity.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: March 24, 2009
    Assignee: SmithKline Beechan Corporation
    Inventor: Jun Tang
  • Patent number: 7501512
    Abstract: This invention relates to newly identified inhibitors of kinases for treating various disorders.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: March 10, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Hideyuki Sato, Mio Takada, Yoshiaki Washio
  • Patent number: 7482455
    Abstract: 3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate YAK3 activity.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: January 27, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Joelle L. Burgess, James F. Callahan, Toshihiro Hamajima, Satoru Ida, Ichiro Mori, Jun Tang
  • Patent number: 7459455
    Abstract: Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: December 2, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Mui Cheung, Kristen Elizabeth Nailor, Douglas McCord Sammond, James Marvin Veal
  • Patent number: 7449484
    Abstract: The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: November 11, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Deborah L. Bryan
  • Patent number: 7427623
    Abstract: Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: September 23, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Deborah Lynne Bryan, Yanhong Feng, Shinichiro Matsunaga, Yutaka Maeda, Yasushi Miyazaki, Masato Nakano, Jean-Philippe Rocher, Hideyuki Sato, Marcus Semones, Domingos J. Silva, Jun Tang
  • Patent number: 7402606
    Abstract: Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: July 22, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: David Gene Barrett, John G. Catalano, David Norman Deaton, Aaron Bayne Miller, John A. Ray, Vicente Samano
  • Patent number: 7338966
    Abstract: The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: March 4, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen Elizabeth Lackey, Edgar Raymond Wood, III
  • Patent number: 7338959
    Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: March 4, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Stanley Dawes Chamberlain, Mui Cheung, Holly Kathleen Emerson, Neil W. Johnson, Kristen Elizabeth Nailor, Douglas McCord Sammond, Marcus Semones
  • Patent number: 7329678
    Abstract: Benzimidazolyl-pyridine derivatives, which are useful as SGK-1 inhibitors are described herein. The described invention also includes methods of making such benzimidazolyl-pyridine derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate SGK-1 activity.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: February 12, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: David Harold Drewry, Robert Neil Hunter, III
  • Patent number: 7307097
    Abstract: Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: December 11, 2007
    Assignee: SmithKline Beechman Corporation
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva
  • Patent number: 7300952
    Abstract: The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-? phosphorylation of I?B. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-?B in which diseases excessive activation of NF-?B is implicated.
    Type: Grant
    Filed: May 29, 2003
    Date of Patent: November 27, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: James F. Callahan, Zehong Wan
  • Patent number: 7282512
    Abstract: Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: October 16, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: John George Catalano, David Norman Deaton, Aaron Bayne Miller, Francis Xavier Tavares
  • Patent number: 7279473
    Abstract: Fused pyradazine derivatives which are usefule as CDK inhibitors are described herein. The described invention alos includes methods of making such fused pyradazine derivatives as wells as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: October 9, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Jennifer G. Badiang, Scott Howard Dickerson, Philip Anthony Harris, David Kendall Jung, Michael Robert Peel, Michael John Reno, Tara Renae Rheault, Kirk Lawrence Stevens, Francis Xavier Tavares, James Marvin Veal
  • Patent number: 7276523
    Abstract: Aminopyridine derivatives of the following formula I which exhibit pharmacological activity at estrogen receptors alpha (ER?) and beta (ER?) are described herein. The described invention also includes compositions and medicaments containing the aminopyridine derivatives as well as processes for the preparation and use of such compounds, compositions and medicaments.
    Type: Grant
    Filed: March 20, 2002
    Date of Patent: October 2, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: David Harold Drewry, Brad Richard Henke
  • Patent number: 7265123
    Abstract: Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: September 4, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: George Stuart Cockerill, Karen Elizabeth Lackey
  • Patent number: 7238813
    Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: July 3, 2007
    Assignee: Smithkline Beecham Corporation
    Inventors: Mui Cheung, Philip Anthony Harris, Masaichi Hasegawa, Satoru Ida, Kazuya Kano, Naohiko Nishigaki, Hideyuki Sato, James Marvin Veal, Yoshiaki Washio, Rob I. West
  • Patent number: 7217710
    Abstract: Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: May 15, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva, Catherine C. K. Yuan