Abstract: The subject invention involves a method for treating hyperproliferative conditions in mammalian epithelial cells comprising administering to the mammal a composition containing a safe and effective amount of a lysophosphatidic acid compound or derivative having the structure ##STR1## or a cyclic derivative thereof having the structure ##STR2## or a pharmaceutically acceptable salt thereof, wherein: a) --Y-- is --0-- or --CH.sub.2 --;b) --Z is --XH, --H or halo;c) each --X-- is independently --0-- or --S--; andd) --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms.

Abstract: Polyol fatty acid polyesters having improved oxidative stability are prepared using the addition of an alkaline material to the synthesized crude polyol fatty acid polyesters before conducting the finishing of the crude. The alkaline material is added in an amount such that the finished product has a pH of from about 6.0 to about 8.5.

Abstract: The subject invention relates to antiperspirant gel stick compositions comprising:(a) an antiperspirant active;(b) a gelling agent comprising:(i) an optically enriched primary gellant selected from the group consisting of 12-hydroxystearic acid, esters of 12-hydroxystearic acid, amides of 12-hydroxystearic acid, and mixtures thereof; and(ii) a secondary gellant selected from the group consisting of n-acyl amino acid amide derivatives;(c) a liquid base material having a solubility parameter of 9 or below;wherein the gel stick has a hardness of 75 grams of force or more.

Abstract: The present invention is for an alcoholic moisturizing after shave lotion having reduced stinging and burning upon application. Said lotion contains a combination of an anti-inflamatory agent and a moisturizing emollient within specified ratios to one another for elimination of stinging and burning when applying said lotion to the skin.

Abstract: The subject invention relates to antiperspirant gel compositions comprising chelators. The subject invention also relates to a process for the manufacture of antiperspirant gel compositions comprising the steps of:(a) pre-mixing a chelator with an antiperspirant active in a substantially water free environment; and(b) adding a gelling agent and a liquid base material to the product of step (a) in a substantially water free environment.

Abstract: The subject invention relates to pharmaceutical compositions comprising a safe and effective amount of a compound having the structure: ##STR1## wherein n is 3 or 4; each R is independently alkyl or alkoxy; and R' is C.sub.1 C.sub.20 alkyl; and a pharmaceutically-acceptable topical carrier.The subject invention also relates to methods for preventing damage to skin, without markedly sensitizing the skin, by topically applying a safe and effective amount of such compounds to the skin.

Abstract: The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising chelating agents having the structure: ##STR1## wherein each --R.sup.1 is independently selected from the group consisting of alkyl, aryl, heteroaryl and heterocycle, or the --R.sup.1 's are covalently bonded together to form a cyclic alkyl or heterocyclic ring; --R.sup.2 and --R.sup.3 are --OR.sup.4, in which case there is no bond or a polar bond between --R.sup.2 and the nitrogen covalently bonded to --R.sup.3, each --R.sup.4 being independently selected from the group consisting of hydrogen, alkyl and aryl, except that both --R.sup.4 's are not methyl when both --R.sup.1 's are furyl; or --R.sup.2 is --O-- and is covalently bonded to the nitrogen which is covalently bonded to --R.sup.3, and --R.sup.3 is --O-- (there being a + charge on the nitrogen to which it is bonded) or nil;wherein the .alpha.

Abstract: The subject invention relates to methods and compositions comprising: a) from about 0.1% to about 5% of a compound having the structure selected from the group consisting of: ##STR1## wherein each R is independently selected from the group consisting of hydrogen, alkyl, and aryl; each R' is independently selected from the group consisting of hydrogen, alkoxy, and alkyl; Z and Z' are independently selected from the group consisting of NH, O, and CH.sub.2 such that when Z or Z' is NH, the other is not O; or a pharmaceutically acceptable salt of any of the aforementioned compounds; and b) a pharmaceutically-acceptable topical carrier.

Abstract: The present invention are anhydrous after shave lotions comprising a perfume, an alcohol, and a low viscosity silicone fluid. Said compositions have less stinging and burning than compositions known in the art. Furthermore, said compositions are economical and have good skin feel characteristics.

Abstract: The present invention provides deodorant compositions for controlling malodor from perspiration comprising a safe an effective amount of a 1,3-diketone compound having the general formula: ##STR1## wherein each W is independently selected from the group consisting of O, S and (CH.sub.2).sub.n, wherein n=1-3; and each X is independently selected from the group consisting of hydrogen, halogen, substituted or unsubstituted alkyl having from about 1 to about 5 carbon atoms, or two X moieties are covalently bonded to form a substituted or unsubstituted alkyl, heteroalkyl, aryl or heteroaryl ring having from about 3 to about 12 atoms including from 0 to about 3 heteroatoms in the ring; and a topical carrier; whereby the composition is suitable for topical application to the skin or to articles of clothing worn in the vicinity of the skin.

Abstract: A continuous, multi-phase process for microaperturing and microembossing a substantially continuous web of substantially planar polymeric film to conform with the image of multiple forming structures, each having a patterned forming surface with a multiplicity of fine-scale apertures and an opposed surface. Each forming structure is open from the apertures in the forming surface to its opposed surface. The web of film has an indefinite length, a first surface, a second surface and a thickness. The thickness is the distance between the first surface and the second surface. The process includes at least two sequential forming phases, one of which involves aperturing of the web of film to coincide with fine-scale apertures in the first forming structure and another of which involves conformance of the web of film to the profile of the fine-scale apertures in the second forming structure.

Abstract: The subject invention relates to pharmaceutical compositions comprising a safe and effective amount of a compound having the structure: ##STR1## wherein each R is alkyl or hydrogen, at least two being alkyl; R' is hydrogen, alkyl or aryl; R" is alkyl or halo; and each X is independently oxygen or sulfur; and a pharmaceutically-acceptable carrier. The subject invention also relates to methods for preventing damage to skin by topically applying a safe and effective amount of such compounds to the skin.

Abstract: A collapsible pump chamber is provided which includes several functional elements of a pump device. For example, the collapsible pump chamber may be a bellows which includes a functional element of an outlet valve, a functional element of a biasing feature, and a functional element of a spin chamber. Consequently, a functional element of all of the downstream functions are incorporated into the bellows. This can significantly reduce costs due to reduced tooling and assembly, for example. In contrast, there are no upstream components incorporated into the bellows which enables the upstream or inlet end of the bellows to be wide open. This wide open upstream end of the bellows makes molding easier.

Abstract: The subject invention relates to methods of regulating skin wrinkles and/or atrophy in mammalian skin comprising topically applying to the skin of a mammal in need of treatment a composition comprising a safe and effective amount of a cyclic polyanionic polyol derivative having the structure: ##STR1## wherein n is an integer from 1 to 3; and each X is, independently, selected from the group consisting of OSO.sub.3.sup.-, OPO.sub.3.sup..dbd., SO.sub.3.sup.--, PO.sub.3.sup..dbd., CO.sub.2.sup.--, and OH; with at least 3 X's being other than OH.

Abstract: A foam dispensing system for a foamable liquid has a means for producing a spray of droplets in which the spray of droplets has key parameters of: the number averaged mean diameter and the mean axial droplet velocity. The foam dispensing system also has a foaming nozzle connected to the means for producing a spray of droplets that is placed in fluid communication with the spray of droplets. The foaming nozzle has a screen which has a plurality of screen openings having a mesh range from 30 to 60 openings per linear inch. Key parameters of the screen are: the percent open area is from about 35% to 60% and the screen openings are larger than the number average mean diameter of the spray of droplets. When the mean axial droplet velocity is at least 8 m/s, the spray of droplets is transformed into a foamed spray as the droplets pass through the plurality of screen openings.

Abstract: An antiperspirant gel stick composition incorporating a gelling agent, including a primary gellant selected from the group consisting of 12-hydroxystearic acid, esters of 12-hydroxystearic acid, amides of 12-hydroxystearic acid, and mixtures thereof and a secondary gellant selected from the group consisting of n-acyl amino acid amide derivatives. The antiperspirant gel stick compositions further incorporate a liquid base material including a non-polar, volatile oil and a relatively polar, non-volatile co-solvent. The combination of the gelling agent and the co-solvent permit the utilization of relatively high levels of a non-polar volatile oils which provide a dry feel.

Abstract: Disclosed are liquid deodorant compositions characterized by the presence of water and zinc phenolsulfonate at a weight ratio of at least about 1:3, most preferably about 3:1; most preferably 3:1; low levels of irritation causing polyhydric alcohols; relatively low monohydric alcohol levels; and the presence of nonionic emulsifiers. Also disclosed is a method for treating or preventing human malodor.

Abstract: This application relates to the use of slitted regions in absorbent members formed of absorbent materials that remain relatively thin until wetted with such fluids. Suitable materials include presently preferred varieties of polymeric foam materials. Single and multi-layered absorbent members incorporating slitted regions are disclosed, as well as the use of pre-formed cup-shaped slits for enhanced initial fluid acquisition. Such slitted regions in combination with planar expansion properties enable the absorbent members to respond dynamically to various fluid loading conditions to create useful structural features. The slitted regions, in combination with absorbent materials having expansion potential in at least one direction within the plane of the absorbent member, cause the slitted regions to buckle and/or deform out of the plane of the absorbent member, thereby causing the slit surfaces to displace angularly and/or translationally with respect to one another.

Abstract: A method and apparatus for forming a tensioned garter and bonding it to a substrate while holding the garter in a predetermined shape. A garter is any continuous loop of elastic material or a laminate of elastic bands and one or more flexible backing sheets. In one embodiment mandrels having a perimeter of the desired garter shape are mounted to a rotating drum. Tensioned elastic ribbons are progressively wrapped, sealed, and cut around the mandrels to form individual tensioned garters which cling to the side walls of the mandrels. In another embodiment each mandrel has a top surface. The upper portion of a garter has sufficient elastic tension to cause it to fold over the mandrel top surface to form a garter flange thereon. A substrate is then engaged with the garter flange and an external sealing means seals the flange to the substrate, using the mandrel top surface as an anvil. In still another embodiment the mandrel top surface has a raised outer rim.

Abstract: The present invention relates to aerosol spray packages having a plurality of spray settings each having been optimized in terms of flow rate, particle size and spray pattern for a particular use. These spray characteristics are created by individual selection of the flow rate and nozzle parameters for each setting. Selecting the spray is easy and convenient to use.