Abstract: Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein R.sub.1, R.sub.2, X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, X.sub.7, and X.sub.8, are as set forth herein are described. These compounds are useful as agents in the treatment of fungal infections.
Type:
Grant
Filed:
April 26, 1995
Date of Patent:
April 14, 1998
Assignee:
Schering Corporation
Inventors:
Alan B. Cooper, Anil K. Saksena, Dinanath F. Rane, Edwin Jao, Viyyoor M. Ginjavallabhan, Ashit Ganguly, Jagdish J. Desai, James Wang
Abstract: Topical compositions for the treatment of corns, calluses and warts comprising a benzenediol or a substituted 1,2-benzenediol and a pharmaceutically acceptable carrier, are described.
Type:
Grant
Filed:
February 12, 1996
Date of Patent:
December 30, 1997
Assignee:
Schering-Plough HealthCare Products, Inc.
Abstract: The invention relates to compounds of the formulas ##STR1## wherein X, R.sub.1, R.sub.2, and R.sub.3, are as described herein. These compounds are useful as antitumor agents. Pharmaceutical compositions containing compounds of formula I are also described. Methods for treating tumors which comprise administration of compounds of formula I are also described. Processes for preparing compounds of formula I are also described.
Type:
Grant
Filed:
December 15, 1994
Date of Patent:
January 21, 1997
Inventors:
Ronald L. Wolin, Adriano Afonso, Joseph M. Kelly, F. George Njoroge
Abstract: The compound of the formula ##STR1## is described. This compound is active in an H.sub.3 receptor assay and is an H.sub.3 antagonist. Accordingly, the compound of formula I is useful in the treatment of diseases and conditions such as asthma, rhinitis, airway congestion, inflammation, cardiac arrhythmias, hypertension, hyper and hypo motility and acid secretion of the gastrointestinal tract, hypo and hyper activity of the central nervous system (CNS), migraine, and glaucoma.
Type:
Grant
Filed:
March 26, 1992
Date of Patent:
June 8, 1993
Assignee:
Harbor Branch Oceanographic Institution, Inc.
Inventors:
Shirley A. Pomponi, Vincent P. Gullo, Ann C. Horan, Mahesh G. Patel, Stephen Coval