Abstract: An injection site is provided which is molded inside out with inwardly extending rings. The rings have a smaller internal diameter than the external diameter of the tubular member to which the injection site is to be connected. The injection site has a central portion for receiving a needle therethrough, and a first, cylindrical portion which is extended into the tubular member. After such insertion, the portion with the attached rings is folded back onto the tubular member. The rings become positioned on the outside of the assembly and are in the compressed state squeezing tightly against the tubular member.

Abstract: A molded glove defines a hand and wrist portion, with the wrist portion defining, in as-molded configuration, longitudinal channels positioned about its circumference. In accordance with this invention, a plurality of circumferential channels are defined on the wrist portion at the end remote from the hand portion, the circumferential channels crossing the longitudinal channels. The thickness of the glove along the longitudinal and circumferential channels is increased over the thickness of the glove in areas adjacent to the channels. The glove exhibits improved resistance to rolling down of the cuff while being worn, when compared with conventional gloves having longitudinal flutes or channels, gloves having beaded cuffs, and the like.

Abstract: A child-proof pill dispenser sealed against contamination is disclosed in the illustrative embodiments. The dispenser includes a pair of relatively rotatable members, which are normally prevented from rotation by axially biased teeth. A force applied against the bias disengages the teeth and permits the members to rotate. Rotation of the members opens a passage for automatic delivery of a pill. The pill is delivered from a storage compartment through an encircled passage into one of the hands required for operating the dispenser. The dispenser has a compression seal between the members for preventing contamination.

Abstract: A thermoplastic pharmaceutical solution container includes a neck portion having at least one port through the neck portion. A thermoplastic port protector or closure covers the port and defines a frangible section. The closure has a length to diameter ratio providing good mechanical advantage leverage to rupture the frangible section when the closure is pushed sideways. A seal is formed with the closure by forcing a die heated above the melting point of the plastic material into the neck portion, removing a portion of the port protector and forming a depression. The frangible section is formed in the vertical side wall of the depression.

Abstract: A container for storing and dispensing sterile liquids is provided with a hermetically sealed primary cap and overcap. The overcap and primary cap are provided, respectively, with an interlocking ring and undercut lip to provide for limited relative axial movement; the overcap and bottle neck are provided with interfitting lugs and ribs to provide for limited rotational movement. An outer ring has internal threads engaging external threads on the overcap and defines a jacking member whereby rotation of the outer ring moves the overcap upwardly to break the hermetic seals.

Abstract: A thermoplastic pharmaceutical solution container includes a neck portion having at least one port through the neck portion. A thermoplastic port protector or closure covers the port and defines a frangible section. The closure has a length to diameter ratio providing good mechanical advantage leverage to rupture the frangible section when the closure is pushed sideways.

Abstract: A method of making a thin-walled tubular container. The container defines a head portion with access means to the contents of the container, and a tail portion defining a sealed line in the tail portion, joining sides of the container into a sealed end with a flat plastic piece being formed integral with the sealed line and extending away therefrom. In accordance with this invention, a pair of spaced rod members are formed as an integral part of the flat, plastic piece, the rod members extending transversely of the longitudinal axis of the container. The flat plastic piece also defines a portion thereof between the rod members which is thinner than any remainder of the plastic piece spaced from the rod members. Accordingly, the rod members and intermediate portion therebetween provide an improved and stronger tail seal.

Abstract: A parenteral liquid infusion set comprising flow tubing as an intermediate site for the potential access of air suitable for connection with another set or the like, and a drip chamber upstream thereof having a constricted drop-forming member. To avoid the possibility of suction of air through the air access site, a tubing section of constricted bore is provided downstream from the potential air access site and so proportioned as to cause the pressure drop of the portion of the set upstream from the potential air access site to be always less than the pressure drop of the portion of the set downstream from the potential air access site under conditions of normal use and specifically under a precise set of test conditions.

Abstract: A flexible, collapsible container defining a relatively rigid shoulder and neck portion at one end and a relatively rigid base at the other end, and having a flexible tubular wall between the shoulder and the base, utilizes first and second pairs of oppositely-disposed gusset portions defined in the flexible walls and positioned respectively adjacent the shoulder and the base. The gussets are adapted to fold outwardly from the shoulder and base as the container collapses.

Abstract: A molded collapsible solution container which defines a body portion having an integral neck portion and a semi-rigid shoulder portion at one end thereof, and is sealed at its opposite end. In accordance with this invention, transverse lines of folding weakness are defined along opposite edges of the shoulder portion to facilitate the collapse of the container.

Abstract: A tubular sealing member defines a bore having an open mouth, plus several spaced, annular sealing members in the bore to grip and seal a tubular projection. In accordance with this invention, at least some of the spaced, annular sealing rings define, in cross section, flexible elongated projections which, in turn, define longitudinal axes which incline toward the open mouth in acute angle relationship to the axis of the bore. The longitudinal axes of the projections are at least 0.01 inch long. The average thickness of each of the flexible projections is less than the length of its longitudinal axis.

Abstract: A family of catalysts is disclosed for providing improved capacity for Limulus lysate solution to precipitate in the presence of extremely low concentrations of endotoxin. The catalyst family includes imidazole, manganese ions, Cleland's reagent, magnesium ions, strontium ions, barium ions, cysteine, lithium ions, and various combinations of the above materials. Solutions of the above catalysts may be used to advantage to reconstitute lyophilized Limulus lysate.

Abstract: A molded glove defines a hand and wrist portion, with the wrist portion defining, in as-molded configuration, longitudinal channels positioned about its circumference. In accordance with this invention, a plurality of circumferential channels are defined on the wrist portion at the end remote from the hand portion, the circumferential channels crossing the longitudinal channels. The thickness of the glove along the longitudinal and circumferential channels is increased over the thickness of the glove in areas adjacent to the channels. The glove exhibits improved resistance to rolling down of the cuff while being worn, when compared with conventional gloves having longitudinal flutes or channels, gloves having beaded cuffs, and the like.

Abstract: A container for storing and dispensing sterile liquids is provided with a hermetically sealed overcap. An outer ring fits over the overcap and the overcap and outer ring have interfitting threads. The outer ring defines a jacking member for moving the overcap axially upwardly on a bottle neck when the outer ring is rotated downwardly. Antibackoff means are provided for axially interlocking the outer ring and overcap, limiting upward rotational displacement of the outer ring with respect to the overcap.

Abstract: A one-piece hanger for a container comprises attachment means to a container and an elongated, flexible hanger member secured at both ends to the attaching means to define a closed loop. The elongated hanger member is positioned in generally longitudinal relationship to the attaching means and defines a pair of first flex sections positioned respectively adjacent the ends of the hanger members, and a pair of spaced second flex sections positioned more remotely from the ends of the flexible hanger member. Accordingly, the hanger member is generally approximately coplanar with the attachment means so that it does not project upwardly away from the container which carries it. However, the hanger can be bent into transverse relation to the attachment means to unfold and expose a large loop for hanging of the container.

Abstract: A ratchet mechanism is provided for preventing disassembly of an outer ring used to jack a hermetically sealed overcap from the neck of a container. The ratchet mechanism comprises a set of teeth on the outer ring which act in cooperation with a set of teeth on the overcap thereby providing a means for preventing rotation of the outer ring in a direction tending to unscrew the outer ring from the overcap, but permitting rotation of the outer ring in the jacking direction.

Abstract: A disposable electrode assembly for establishing electrical contact with an underlying skin surface includes a relatively thin transparent base member having a central hub portion and an adhesive-coated undersurface, a conductive gel-impregnated sponge contact contained in a downwardly facing recess located in the hub, and a relatively thick and inflexible cover member coextensive with the base member. In storage the cover member is attached to the undersurface of the base member by the adhesive and the sponge is confined within the recess. Prior to use the base member is peeled away from the cover member to expose the adhesive surface, which when applied to a skin surface holds the sponge contact in compression-contact therewith. The base is transparent to enable the user to detect skin irritation and incomplete adhesion of the base member, and may be provided with apertures to facilitate breathing of the underlying skin.

Abstract: A flexible, collapsible container having walls essentially 0.01 to 0.03 inch thick and defining relatively thin lines of folding weakness in the container to facilitate flat collapse. The thickness of the lines of folding weakness is less than that of the surrounding walls. The cross-sections of the lines of folding weakness define arcs, the outer surfaces of which have a circumferential length which is 40 to 60 percent greater than the direct width of the lines of folding weakness. Preferably, the container is made of a relatively stiff polyolefin plastic such as polyethylene, polypropylene, or copolymers thereof of similar stiffness, particularly biaxially oriented materials.

Abstract: A fluid transfer device is provided for administration of medicament to a patient. The device includes a plastic housing having a first inlet, a second inlet and an outlet, and an umbrella check valve coupling the inlets and outlets. The umbrella check valve is positioned so as to permit flow from the first inlet to the second inlet and from the second inlet to the outlet, but to block flow from the second inlet to the first inlet and from the outlet to both the first inlet and the second inlet.

Abstract: An in-line cannula valve assembly for controlling flow through a conduit, comprising a housing, including a collapsible housing part having a flexible wall, joined to a relatively rigid housing part. A first fluid passage in the relatively rigid housing part are provided as a portion of the conduit. A cannula element is positioned with its piercing point end in the second fluid passage, and the opposite end is positioned adjacent the first fluid passage. The cannula element is adapted for longitudinal movement through the first and second passages. A longitudinal groove is defined in the cannula element extending to the opposite end, but terminating short of the piercing point end. Sealing means are positioned about the cannula element. Thus, the cannula element may be positioned in either a first, closed position in which the longitudinal groove is spaced from the sealing means, or a second.