Patents Represented by Attorney, Agent or Law Firm John P. Parise
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Patent number: 5512247Abstract: An analyzer has a horizontally disposed baseplate on which primary containers and secondary containers are disposed, a pipetting needle, a transport device, and a control device. The pipetting needle is formed of an electrically conductive material and is connected to a metering device by a tubing, and is for transferring a predetermined volume of liquid each time from a primary container to a secondary container. The transport device is for the controlled transport of the pipetting needle in three directions at right angles to one another, two of the transport directions extending horizontally and the third transport direction extending vertically. The control device is for controlling the metering device and the transport device.Type: GrantFiled: April 11, 1995Date of Patent: April 30, 1996Assignee: Hoffmann-La Roche Inc.Inventors: Guido Bonacina, Thomas Caratsch, Rolf Moser
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Patent number: 5502076Abstract: Vitamin E acetate, C.sub.3 -linked triesters, glycerin, t-butanol, and transesterified oil/polyethylene glycol are effective dispersing agents for use with hydrofluoroalkanes. Effective amounts of the above are effective in suspending medicaments which are useful in inhalation aerosols, and especially meter-dose inhalers.Type: GrantFiled: March 8, 1994Date of Patent: March 26, 1996Assignee: Hoffmann-La Roche Inc.Inventors: Suresh C. Dixit, David Goldman, John J. Hu, Krish Sethachutkul
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Patent number: 5496519Abstract: A processing station for making a fluorescence polarization measurement on a sample in a cell under examination in a device for chemical and biochemical analysis, the analytical device containing a conveyor for conveying cells. In order to make fluorescence polarization measurements outside the conveyor, the processing station is separated from the conveyor and contains a measuring device means for making fluorescence polarization measurements on a sample in a cell, and an automatically controlled change-over and positioning device for removing individual cells from the conveyor, transferring a removed cell to a measuring position in the measuring device, and returning the cell to its original position on the conveyor after the measurement.Type: GrantFiled: July 21, 1994Date of Patent: March 5, 1996Assignee: Hoffmann-La Roche Inc.Inventor: Gottlieb Schacher
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Patent number: 5482863Abstract: An analytical device incorporating a system for suspending particles includes a conveying device for positioning a pipetting needle at a distance from the central longitudinal axis of the reaction vessel. Particles are suspended by delivering amounts of liquid reagent to two different positions at a predetermined distance from the central longitudinal axis of a reaction vessel, such delivery generates a flow in the reaction vessel which suspends particles exclusively by injection of liquid, thus avoiding the need for subsequent shaking.Type: GrantFiled: September 7, 1994Date of Patent: January 9, 1996Assignee: Hoffmann-La Roche Inc.Inventor: Rolf Knobel
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Patent number: 5482864Abstract: An analytical device incorporating a system for suspending particles includes a conveying device for positioning a pipetting needle at a distance from the central longitudinal axis of the reaction vessel. Particles are suspended by delivering amounts of liquid reagent to two different positions at a predetermined distance from the central longitudinal axis of a reaction vessel, such delivery generates a flow in the reaction vessel which suspends particles exclusively by injection of liquid, thus avoiding the need for subsequent shaking.Type: GrantFiled: April 24, 1995Date of Patent: January 9, 1996Assignee: Hoffman-La Roche Inc.Inventor: Rolf Knobel
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Patent number: 5462865Abstract: A novel process for producing tocopherols and their precursors is described.Type: GrantFiled: March 22, 1994Date of Patent: October 31, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Achim Stocker, Wolf D. Woggon
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Patent number: 5462715Abstract: A conveyor is useful for conveying cuvettes to one or more processing stations. The conveyor has a plate-shaped rotor magazine with a number of resilient retaining elements for releasably holding cuvettes along the periphery of the magazine. This allows the cuvettes to be inserted and removed by a simple linear motion. Preferably, the retaining elements are constructed to cover the openings in the cuvettes while they are being held along the periphery of the magazine.Type: GrantFiled: August 8, 1994Date of Patent: October 31, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Bruno Koch, Gottlieb Schacher
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Patent number: 5454974Abstract: Compounds of the formula ##STR1## wherein X.sup.1 denotes fluorine or chlorine and X.sup.2 denotes hydrogen, fluorine or chlorine; R.sup.1 is 3E-alkenyl, 4-alkenyl, 2E-alkenyloxy or 3-alkenyloxy; n stands for the number 0 or 1; one of the groups Y.sup.1 and Y.sup.2 is a single covalent bond, --COO--, --OOC--, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O-- or --OCH.sub.2 -- and the other of the groups Y.sup.1 and Y.sup.2 is a single covalent bond; and rings A.sup.1 and A.sup.2 each individually are substituted or unsubstituted trans-1,4-cyclohexylene, in which optionally 2 non-adjacent CH.sub.2 groups are replaced by oxygen, or substituted or unsubstituted 1,4-phenylene, in which optionally 1 CH group or 2 CH groups is/are replaced by nitrogen; with the proviso that X.sup.2 denotes fluorine or chlorine and/or Y.sup.1 or Y.sup.2 denotes --CH.sub.2 O-- or --OCH.sub.2 -- when simultaneously X.sup.1 is fluorine and R.sup.1 is 3E-alkenyl,and their use for liquid crystalline mixtures and electro-optical purposes.Type: GrantFiled: January 6, 1994Date of Patent: October 3, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Arthur Boller, Richard Buchecker, Martin Schadt, Alois Villiger
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Patent number: 5455337Abstract: Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.- and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy- or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.Type: GrantFiled: September 16, 1992Date of Patent: October 3, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Rene Devos, Walter Fiers, Jose van der Heyden, Geert Plaetinck, Jan Tavernier
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Patent number: 5447662Abstract: Polymeric coatings having optically non-linear or optically anisotropic properties in selected areas and of any arbitrary shape including a pattern. These zones are sharply defined from surfaces having centro-symmetrical or isotropic configurations or from surfaces with different optically non-linear or anisotropic properties. The polymeric coating has optically non-linear and/or mesogenic side chains, selected surface areas of which are cross-linked by the action of light, the zones which have optically non-linear or anisotropic properties being subjected to the influence or orienting fields or forces during the cross-linking process. The distances between optically different zones are limited to typically about 1 .mu.m.Type: GrantFiled: December 18, 1991Date of Patent: September 5, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Rolf-Peter Herr, Martin Schadt, Klaus Schmitt
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Patent number: 5446189Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, n, m, o, p, and q are as hereinafter set forth,and, when R.sub.2 is hydrogen, pharmaceutically acceptable salts thereof with bases, are described. The compounds of formula 1 are potent inhibitors of phospholipases A.sub.2 (PLA.sub.2 's) and are therefore useful in the treatment of inflammatory diseases, such as psosiasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, myocardial ischemia/reperfusion, and trauma induced inflammation, such as spinal cord injury.Type: GrantFiled: March 22, 1994Date of Patent: August 29, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Mathew Carson, Ru-Jen L. Han, Ronald A. LeMahieu, Vincent S. Madison
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Patent number: 5443792Abstract: A pipetting device contains a pipetting needle connected to metering device for transferring a volume of liquid from a primary vessel to a secondary vessel. Primary vessel and secondary vessels are disposed on the same or different vessel carrier units, and each vessel has a clearly defined position relative to the vessel carrier unit. Additionally, a device is provided for controlling conveyance of the pipetting needle in three directions. The controlling device controls the metering device and the conveyance device. The pipetting device independently determines coordinates of the pipetting positions for each vessel carrier unit. For each vessel carrier unit at least one reference member, which is part of the vessel carrying unit or is directly and permanently connected thereto, may be provided. These vessel carrier units have flat surfaces which are accessible to sensing the pipetting needle.Type: GrantFiled: October 19, 1994Date of Patent: August 22, 1995Assignee: Hoffmann-La Roche Inc.Inventor: Jurg Buhler
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Patent number: 5437841Abstract: A cell for performing optical measurements in a automatic analyzer includes a cell having a tubular body. The body has two plane-parallel walls, and is open at one end and closed at the opposite end by a bottom wall. At the open end of the body, tongues extend perpendicularly outward from each plane-parallel wall. Each tongue includes a recess, with each tongue and its recess being symmetrically placed relative to another tongue and its recess with respect to the longitudinal axis of the cell.Type: GrantFiled: January 21, 1994Date of Patent: August 1, 1995Assignee: Hoffmann-La Roche Inc.Inventor: Alfons Balmer
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Patent number: 5438052Abstract: Cephalosporin derivatives have the formula ##STR1## wherein Z.sup.1, Z.sup.2, X, Y, P, Q, m, n and p are as defined in the following text. Also described are the readily hydrolyzable esters and pharmaceutically compatible salts of these compounds, and hydrates of compounds of formula I, their esters and salts. Processes are provided for manufacture and pharmaceutical preparations which contain these compounds. Intermediates from the manufacture of these compounds are described, as is the use of the compounds in the control of illnesses and for the manufacture of the aforementioned preparations.Type: GrantFiled: November 20, 1992Date of Patent: August 1, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Peter Angehrn, Andre Furlenmeier, Paul Hebeisen, Werner Hofheinz, Helmut Link
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Patent number: 5432069Abstract: A tocopherol cyclase is produced in homogenous form which acts on phytyl benzoquinol derivatives to produce R', R', R'-tocopherols enantioselectively. The cyclase has a molecular weight of from about 48 kD to about 50 kD as determined by SDS-PAGE. The cyclase is isolated from Chlorella protothecoides, Dunaliella salina and wheat leaves of the Fidel variety.Type: GrantFiled: July 17, 1992Date of Patent: July 11, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Fiona Gruninger, Erich Hochuli, Peter K. Matzinger
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Patent number: 5419279Abstract: An apparatus for use in depositing and staining cytological material on a microscope slide has an elongated hollow tube, a base member, at least one flange, and a base plate. The base member is attached to the bottom end of the tube and projects outwardly from the tube perpendicular to the longitudinal axis of the tube. At least one flange is connected to the base member and outwardly-extends from the base member perpendicular to the longitudinal axis of the tube. The base member has a recessed area configured to receive the microscope slide, and slots configured and dimensioned to receive the flange. A passage in the base plate extends from each slot to releasably secure the respective flange when the tube is rotated. As designed, this apparatus advantageously allows individual staining of a slide, thereby preventing false-positive results due to floater cells which can translocate between slides in a common bath.Type: GrantFiled: March 14, 1994Date of Patent: May 30, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Charles L. Carrico, Jr., William A. Fox, Ernest A. Knesel, Jr.
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Patent number: 5399292Abstract: Fluoro-substituted phenyl-cyclohexylacetylenes have the formula: ##STR1## wherein R signifies alkyl, alkoxy, alkenyl or alkenyloxy with 1 or, respectively, 2 to 12 carbon atoms in which one CH.sub.2 group can be replaced by oxygen and/or one or more hydrogen atoms can be replaced by fluorine atoms, with the proviso that two oxygen atoms are not directly adjacent;A.sup.1 represents 1,4-phenylene, pyridine-2,5-diyl, pyrimidine-2,5-diyl, trans-1,4-cyclohexylene or trans-1,3-dioxane-2,5-diyl;A.sup.2 signifies trans-1,4-cyclohexylene or 1,4-phenylene which is optionally substituted with fluorine;Z.sup.1 signifies a single covalent bond, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --CH.sub.2 O--, --(CH.sub.2).sub.4 --, --O(CH.sub.2).sub.3 --, --(CH.sub.2).sub.3 O-- or, when ring A.sup.1 represents a saturated ring, also the trans form of --CH.dbd.CH(CH.sub.2).sub.2 -- or --CH.dbd.CHCH.sub.2 O--;Z.sup.2 signifies a single covalent bond, --CH.sub.2 --CH.sub.2 --, --OCH.sub.2 --, --CH.sub.2 O--, --(CH.sub.2).sub.Type: GrantFiled: May 2, 1994Date of Patent: March 21, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Richard Buchecker, Martin Schadt
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Patent number: 5399720Abstract: The invention relates to a novel process for producing a compound having the formula ##STR1## wherein R.sup.1, R.sup.2 and X are described herein, via corresponding .beta.-keto- and .beta.-hydroxy-.delta.-lactones, as well as novel intermediates which occur in the process.Type: GrantFiled: June 15, 1993Date of Patent: March 21, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Martin Karpf, Ulrich Zutter
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Patent number: 5397576Abstract: Substantially dried free flowing micronutrient compositions having up to 15% by weight of a micronutrient, a binder, and a densifying agent are produced according to the invention. The process for producing the compositions includes the steps of dissolving or dispersing up to approximately 15% by weight of the micronutrient and a binding amount of a binder in water to obtain an aqueous mixture; suspending a densifying amount of a solid densifying agent in the mixture, the densifying agent having a particle size of approximately 40 mesh to approximately 325 mesh; and spray drying the suspension to produce the micronutrient composition.Type: GrantFiled: May 14, 1993Date of Patent: March 14, 1995Assignee: Hoffmann-La Roche Inc.Inventors: William J. Mergens, Joseph E. Raymond
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Patent number: 5389698Abstract: An oriented photopolymer is a polymer where photomodification is initiated by irradiation with plane-polarized light and where the molecular configuration has a preferred orientation as a result of linear polarization. These polymers have optically anisotropic and other novel properties.Type: GrantFiled: September 21, 1993Date of Patent: February 14, 1995Assignees: Hoffmann-La Roche Inc., Niopic Moscow Research and Production AssociationInventors: Vladimir G. Chigrinov, Vladimir M. Kozenkov, Nicolic V. Novoseletsky, Victor Y. Reshetnyak, Yuriy A. Reznikov, Martin Schadt, Klaus Schmitt