Patents Represented by Attorney, Agent or Law Firm John Prince
  • Method for the identification of inhibitors of the binding of ARE-containing mRNA and a HuR protein
    Patent number: 7399583
    Abstract: The present invention provides for a method for identifying an agent that has an inhibitory effect on the complex-formation of an ARE-containing mRNA and an HuR protein.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: July 15, 2008
    Assignee: Novartis AG
    Inventors: Manfred Auer, Nicole-Claudia Meisner, Volker Uhl
  • Methods and reagents for protease inhibition
    Patent number: 7029877
    Abstract: There is provided a protease inhibitor and a method of inhibiting a protease selected from the group consisting of thrombin, chymotrypsin and neuropsin, by contacting the protease with an effective amount of a member of the phosphoethanolamine binding protein (PEBP) family.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: April 18, 2006
    Assignee: Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Instittue for Biomedical Research
    Inventors: Hugo Albrecht, Ulrich Hengst, Denis Monard
  • Cell surface molecule-induced macrophage activation
    Patent number: 6197294
    Abstract: This invention provides cells containing recombinant polynucleotides coding for cell surface molecules that, when expressed in the cell, result in rejection of the cell by the host immune system. The invention also provides methods of using such cells, and capsules for delivery of biologically active molecules to a patient.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: March 6, 2001
    Assignee: Neurotech S.A.
    Inventors: Weng Tao, Shou Wong, William F. Hickey, Joseph P. Hammang, E. Edward Baetge
  • Methods and compositions for cryopreservation of cells and tissues
    Patent number: 6176089
    Abstract: The present invention provides methods and compositions for cryopreservation of cells or tissues encapsulated in a bioartificial organs, wherein the integrity and the viability of the encased cells are maintained, along with the integrity of the artificial capsule used to encase the cells. The method provides novel conditions for cryopreserving a bioartificial organ in a freezing container using a minimum volume of added cryopreservative solution necessary to maintain both the structural integrity of the jacket encasing the bioartificial organ, and the viability of the cells encased therein.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: January 23, 2001
    Assignee: Modex Th{acute over (e)}rapeutics
    Inventor: Nicola Bouche
  • Apparatus for deposition of ultrasound energy in body tissue
    Patent number: 6135971
    Abstract: An apparatus for providing ultrasonic energy for deposition in body tissue including an array of elements having at least two different sizes and at least one element being aperiodically spaced with the respect to other elements in the array. Excitation of the elements produces a beam of ultrasonic energy having reduced grating lobes. Reduced grating lobe magnitude permits improved ultrasonic beam focusing and/or the use of larger element sizes.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: October 24, 2000
    Assignee: Brigham and Women's Hospital
    Inventors: Erin Hutchinson, Mark Buchanan, Kullervo Hynynen
  • Neuron-restrictive silencer factor nucleic acids
    Patent number: 5935811
    Abstract: The present invention relates to neuron-restrictive silencer factor proteins, nucleic acids, and antibodies thereto.
    Type: Grant
    Filed: March 3, 1995
    Date of Patent: August 10, 1999
    Assignee: California Institute of Technology
    Inventors: David J. Anderson, Christopher J. Schoenherr