Patents Represented by Attorney John R. Merkling
  • Patent number: 8337380
    Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a valve design that facilitates loading and unloading of blood bags and associated tubing and bag sets. The valves comprise a rotating head, mounted on a shaft, which assumes a “load” position. The head pivots to an “open” position, which secures the tube in its designated location, but which maintains an open lumen through the tube. When the head is in a “closed” position, blood components cannot flow through the tube. The valve apparatus comprises means for maintaining a constant pressure on the tube and contact with the tube as the tube is melted and sealed.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: December 25, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Bruce Ellingboe, Hong Duc Nguyen
  • Patent number: 8337379
    Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity, or. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: December 25, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Christopher Fletcher, William Sweat, Jeremy Kolenbrander, Aditya Dalvi, John R. Linder
  • Patent number: 8339592
    Abstract: An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. A control circuit uses the measurements to control the delivery of an effective dose of illumination to blood or blood products in a bag or container. One or more light integrating optical chambers in the radiometer allow a single light sensor to sense light across an entire field. Thermistors in the irradiating apparatus or the radiometer or both sense the temperature of photo sensors. The control circuit compensates for temperature-dependant variations in the output of the photo sensors.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: December 25, 2012
    Assignee: Terumo BCT Biotechnologies, LLC
    Inventors: Dennis J. Hlavinka, Terrence M. Cussen, Daniel T. McGinnis
  • Patent number: 8296071
    Abstract: Methods, devices and device components are presented for uniformly treating fluids undergoing mixing with electromagnetic radiation. In one aspect, the present invention provides methods of treating a fluid undergoing continuous fluid mixing wherein net radiant energies necessary to provide uniform treatment of the fluid samples with electromagnetic radiation are calculate on the basis of the volume, mass or mixing rate of the fluid or any combination of these variables. In another aspect, the present invention provides algorithms for determining net radiation energies, radiant powers, and/or illumination times necessary for providing uniform treatment of fluid samples. The present invention provides methods for uniformly reducing pathogens in biological fluids, including blood and blood components.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: October 23, 2012
    Assignee: Terumo BCT Biotechnologies, LLC
    Inventors: Richard Alan Edrich, Laura Goodrich, Glen Delbert Antwiler
  • Patent number: 8287742
    Abstract: Method for separating a volume of whole blood into at least a plasma component and a red blood cell component comprising centrifuging a separation bag containing a volume of whole blood so as to separate therein at least a first component comprising plasma and a second component comprising red blood cells; transferring the first component into a plasma component bag during centrifugation of the separation bag; transferring into the separation bag a volume of wash solution from a wash solution bag during centrifugation of the separation bag; mixing the volume of wash solution with the second component; centrifuging the separation bag so as to separate therein a washed red blood cell component and a supernatant component; and transferring the supernatant component into a waste bag during centrifugation of the separation bag.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: October 16, 2012
    Assignee: Terumo BCT, Inc.
    Inventor: Brian M. Holmes
  • Patent number: 8277406
    Abstract: A method for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: October 2, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas Felt, Brian M. Holmes, Bruce Gibbs
  • Patent number: 8241196
    Abstract: The invention relates to apparatus for controlling the processing of blood into blood components, particularly components for stroboscopic LED light sources for centrifuges. A digital control circuit controls a high amperage linear voltage regulator. The voltage regulator charges a capacitor bank, which in turn powers LED light sources. The digital control circuit comprises an N-channel switched mode FET. The switched mode FET receives a pulsed digital signal from the microprocessor controlling the blood processing apparatus. A by-pass resistor in parallel with the FET allows most of the current to flow past the FET, thus minimizes heating of the FET. The performance of the FET, therefore, remains stable despite extended use of the apparatus.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: August 14, 2012
    Assignee: Terumo BCT, Inc.
    Inventor: Joseph A. Scibona
  • Patent number: 8226537
    Abstract: A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber a baffle within a separation area. The baffle may have a plurality of vanes with openings therein. A protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: July 24, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: John Pittinger, Robert Langley, Mary Langley, legal representative, Logan Fender
  • Patent number: 8163555
    Abstract: A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication with the cellular growth area allows for hermetically removing a sample containing cellular matter. This may comprise an elongated tube, or a plurality of parallel tube segments. The parallel tube segments have inflow ends and outflow ends, and the inflow ends are joined at a first common juncture and the outflow ends are joined at a second common juncture. The common junctures may comprise valves.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: April 24, 2012
    Assignee: Terumo BCT, Inc.
    Inventor: Glen Delbert Antwiler
  • Patent number: 8139814
    Abstract: An audio speaker with at least two electric coils on opposite sides of at least one ferro-magnetic plate, the coils and plate forming a radial electro-magnet. A radial electro-magnet can offer many advantages in stereo loudspeakers. The coils are electrically driven in opposite directions. Multiple sets of two coils and intervening ferro-magnetic plate may be provided, adjacent sets being separated by a non-magnetic plate.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: March 20, 2012
    Inventors: William B. Rottenberg, Robert S. Robinson
  • Patent number: 8114003
    Abstract: A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, and an outlet line. Apparatus tests flow conditions using a red light-green light sensor to detect non-recoverable hemolysis during priming by identifying a high R/G ratio, preferably a ratio of greater than or equal to fifty (50), prior to the beginning of the first return of blood components to a donor followed by identifying a R/G ratio at least as great as one and one tenth (1.1) together with a green signal less than a predetermined value, preferably less than or equal to one thousand (1000) reflectance units. If these conditions are detected, an alarm is given and the apheresis procedure is discontinued.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: February 14, 2012
    Assignee: CaridianBCT, Inc.
    Inventors: Todd Curtis Green, Bruce W. Gibbs
  • Patent number: 8070663
    Abstract: A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: December 6, 2011
    Assignee: CaridianBCT, Inc.
    Inventor: William Sweat
  • Patent number: 8066888
    Abstract: A blood cell collection system having means for detecting when a cell separation chamber has filled with white blood cells, and flushing the cells out of the cell separation chamber into a collect bag. A red-green sensor senses the optical characteristics of fluid leaving the cell separation chamber. A baseline value is calculated. The device calculates a ratio of the intensities of red light and green light and a peak-to-peak ratio of intensities. If either ratio exceeds thresholds computed from the baseline, the device flushes the cells into the collect bag. A camera detects white cells passing into the cell separation chamber and the device calculates the number of cells being collected. If the calculated number of collected cells exceeds a certain limit, the cell separation chamber is flushed. If the device is unable to establish a baseline, the donation can proceed, relying solely on the calculated number of collected cells.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: November 29, 2011
    Assignee: CaridianBCT, Inc.
    Inventors: William Sweat, Jeremy Kolenbrander, John R. Lindner, Jennifer Hinz
  • Patent number: 8062202
    Abstract: A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber being coupled to an elutriation chamber, a first detector for the separation chamber to detect light from an observation region, a computational apparatus distinguishing at least two regions in the observation region and distinguishing incipient spill over of cellular components out of the elutriation chamber as a function of light intensity received from the at least two regions in the separation chamber, and a controller regulating speed of at least one pump or of the separation chamber in response to signals from the computational apparatus to avoid spill over.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: November 22, 2011
    Assignee: CaridianBCT, Inc.
    Inventor: William Sweat
  • Patent number: 8057376
    Abstract: A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: November 15, 2011
    Assignee: CaridianBCT, Inc.
    Inventors: James R. Ladtkow, Joseph A. Scibona, Jeremy Kolenbrander
  • Patent number: 7963901
    Abstract: A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having a protruding inlet therein. The protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet. The cell separation chamber may have a baffle within a separation area. The baffle may have a plurality of vanes with openings therein.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: June 21, 2011
    Assignee: CaridianBCT, Inc.
    Inventors: Robert W. Langley, John Pittinger, Logan Fender
  • Patent number: 7964048
    Abstract: The present invention provides thermoplastic tubes, thermoplastic melting plates, thermoplastic tube connecting apparatus, and methods for using the same.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: June 21, 2011
    Assignee: CaridianBCT, Inc.
    Inventors: Dennis J. Hlavinka, Keith Manica, Frank Corbin, III, Terrence M. Cussen
  • Patent number: 7951059
    Abstract: A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: May 31, 2011
    Assignee: CaridianBCT, Inc.
    Inventor: William Sweat
  • Patent number: 7943916
    Abstract: The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components with a two-dimensional optical measurement and control device. The method may comprise the steps of providing a blood processing system comprising a density centrifuge blood processing system and an elutriation blood processing system; filling the elutriation blood processing system with a desired component; measuring a cellular flux of cells entering the elutriation blood processing system with a two-dimensional optical control system; and flushing the elutriation blood processing system.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: May 17, 2011
    Assignee: CaridianBCT, Inc.
    Inventors: Lee F. Carter, Jeremy P. Kolenbrander, James R. Ladtkow, Joseph A. Scibona, Jeffrey A. Steward, Chris Fletcher
  • Patent number: 7935043
    Abstract: A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, an outlet line and a storage solution line in fluid communication with the outlet line at a junction. The apparatus controls pumps to conduct a predetermined quantity of storage solution to a collected blood component. The apparatus also purges blood components in the tubing set by applying a negative pressure and positive pressure. A disposable blood processing set has a separation chamber; a tubing set including an inlet line in fluid and an outlet and a storage solution line connected to the outlet line at a junction.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: May 3, 2011
    Assignee: CaridianBCT, Inc.
    Inventor: Logan Fender