Abstract: Homocysteine thiolactone perchlorate is prepared from the corresponding homocysteine thiolactone hydrochloride and optimally about two equivalents of perchloric acid as reactants. A preferred solvent utilized is chloroform-methanol (4:1) solution and a preferred temperature range is 0.degree.-85.degree. C. with the lower limit dependent upon the particular solvent and the upper limit of about 186.degree. C. dependent upon the melting point of the product crystals. The preferred perchloric acid reactant may be replaced with perchlorate salts such as AgClO.sub.4 or KClO.sub.4. The product perchlorate salt is soluble in organic solvents, whereas other known salts such as the hydrochloride are only water soluble. This property is thought to influence the growth effect of the perchlorate salt in animals, such as rabbits, and to influence the unique effect of the perchlorate salt on the growth of malignant tumors in animals, such as mice.

Abstract: The apparatus of the present invention includes a quartz flask for containing 71% nitric acid and the organic matrix to be destroyed, a Soxhlet extractor disposed above the flask, and a Friedrich coldfinger reflux condenser disposed above the extractor. A Meeker or Fisher burner is employed to provide heat to the flask and distill the acid, and the vapors are condensed within the condenser and transmitted to the extractor. An adjustable volume displacement cylinder is disposed within the extractor so as to control siphoning of the acid condensate from the extractor back into the flask. The distillation-condensation-siphoning procedure of the present invention is automatically operative once the displacement cylinder is adjusted. The organic matrix is completely destroyed so as to produce a clear, colorless acid solution within which the trace inorganic salts are disposed. The acid solution may be subsequently qualitatively and quantitatively analyzed in accordance with known techniques.

Abstract: A method for preparing novel peptide alcohols exemplified by the reduction of enkephalins and particularly the met-enkephalin to produce pentapeptides and tetrapeptides of the following formulaH-Tyr-DAla-Gly-Phe-Methioninol (1)H-Tyr-DAla-Phe-Methioninol (2)Additional alcohols having a carbon or C-number exceeding or less than 4 or 5 may also be prepared. These compounds are produced by solid phase peptide synthesis developed by R. B. Merrifield in Advances in Enzymology, 32:221 (1969 ) in which the terminal carboxyl group is reduced to the alcohol under the influence of lithium borohydride.

Abstract: A class of tetrapeptides having opiate activity having the formulaH-Tyr-X-Y-Zwherein X is D-amino acid radical; Y is Phe, DPhe, MePhe, DMePhe, Trp or DTrp; Z is Met-OH, Met-ol, Met(O)-ol, Met-OR, Met-NH.sub.2, MetHNR, DMet-OH, DMet-ol, DMet(O)-ol, DMet-OR, DMet-NH.sub.2, DMetNHR, Leu-OH, Leu-ol, Leu-OR, Leu-NH.sub.2, Leu-NHR, DLeu-OH, DLeu-ol, DLeu-OR, DLeu-NH.sub.2 or DLeu-NHR, and R is C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -hydroxyalkyl, are disclosed.

Abstract: Two pairs of dies are arranged adjacent each other so that each pair can clamp onto a metal sheet between them. One pair is situated slightly below, or stepped down from, the other pair. One pair of dies clamps onto the sheet, and then the other pair is clamped onto it to bend the sheet so that a step is formed in the sheet between the two pairs of dies, corresponding to the step down from one pair of dies to the other.

Abstract: Laboratory apparatus for cloning mammalian cells includes a support plate and a plurality of tubular cylinders fixedly secured within the plate and projecting from one face thereof. All of the cylinders, with the exception of one pair, are disposed within a concentrated array defined within a predetermined sector region of the plate, the remaining pair of cylinders being located remote from the sector array yet equidistantly spaced from each other and from the sector array so as to complete the distribution pattern. A substantially C-shaped ring member is fixedly secured to, or integrally formed with, the opposite face of the support plate, in order to facilitate maneuverability of the assemblage when placing the same onto a Petri dish for isolating the colonies developing thereon. The plate and ring member are fabricated from transparent polycarbonate in order to permit the colonies to be identified or viewed by background lighting techniques.

Abstract: Steroidal cyclotriphosphazenes of the formula ##STR1## wherein R is the residue of a 3- or 17-hydroxysteroid and R.sub.2 is alkyl, are hydrolytically labile compounds adapted for slow release in vivo of active steroidal compounds of the formula ROH.

Abstract: The present invention relates to a group of novel compounds defined as covalently bound poly-N-vinyl pyrrolidinone (PVP)-heparins. These compounds are synthesized on the basis of a novel concept that heparin molecules can be modified to have new desirable qualities by binding heparin covalently to an appropriate polymer carrier which has the desired characteristics.Heparin is hydrophilic and thereby insoluble in organic solvent. It has a short half-life in vivo. PVP-heparins, on the other hand, not only retain the anticoagulant activities of heparin, but also have the solubility (in organic solvents) and longer half-life in vivo of PVP.PVP-heparins are produced either in anhydrous or heterogeneous media wherein PVP is activated by thionyl chloride to produce an imidoyl ion which is subsequently bound to heparin. PVP-heparin produced in anhydrous media is chloroform soluble and has been found useful for coating plastics and similar substances.

Abstract: Spring contact element comprising a metal spring leaf for mechanically fastening and electrically connecting it to the end of a cable and a contact spring to provide a plug-in connection with a counter contact element wherein said contact spring includes a base leg attached to the fastening means and passing, at the plug-in end of said spring contact element, via a bend having a predetermined bending radius, into a free end leg describing an acute angle with the base leg, and an insulating case for such spring contact element wherein a first contact chamber to receive said spring contact element through an opening in a first front side and a second contact chamber to receive said counter contact element from the second front side facing said first front side are provided and the broadside of the cross section of said second second contact chamber is twisted about 90.degree.

Abstract: An electrically operated dehydrator in the form of perforated trays stacked one on top of the other where the bottom tray is equipped with a blower-heater package and the top tray forms a solid cover. Air is drawn in by the blower from underneath the bottom tray, it is heated and then forced to rise through the perforated trays. A portion of the air is being recirculated into the blower through a central duct whereas the remainder of the air is allowed to bleed-out through a series of openings in the top.

Abstract: A blend which contains homopolymers useful for imparting wet and dry strength to pulp and paper fibers which comprises a major amount of non-ionic polyacrylamide, together with glyoxal to impart crosslinking and a cationic regulator selected from the group consisting of a low molecular weight dimethyl amine epichlorohydrin copolymer, a low molecular weight ethylene dichloride ammonia condensation polymer, and a polyvinyl benzyl trimethyl ammonium chloride polymer. A buffer such as tetrasodium pyrophosphate may be used. A dosage of 0.2-5% by weight (preferred 0.5-2% by weight) based on the dry weight of fiber is utilized.

Abstract: An electric air heating element is designed for positioning in the cylindrical or conical outlet tube of a hair dryer. It consists of a star-shaped coil carrier in the shape of four fins extending radially from a common center line in the axis of the outlet tube towards the tube walls. The fin edges are serrated by adjacent rectangular slots, the slots on each edge penetrating alternately to a shallow and to a greater depth, and a ribbon-shaped resister laid into these slots is helically wound around the coil carrier. In this way successive windings lie in different planes and air turbulence around the heating coil is thereby increased, improving the heat transfer between the resistor windings and the throughflowing air.

Abstract: Water-in-oil emulsions of polyacrylamide or other water soluble vinyl addition polymers having amide functionality can be reacted with formaldehyde and a secondary amine containing 2-8 carbon atoms followed by quaternization to prepare water-in-oil emulsions of quaternized cationically modified polyacrylamides.The resultant water-in-oil emulsions are stabilized against cross linking by the addition to the water-in-oil emulsions of an aqueous solution of a water soluble phosphorous compound having a P--H bond. The phosphorous containing compound is added in such a quantity so as to provide from 1.6-25% by weight of the phosphorous compound based on the weight of the polymer contained within the water-in-oil emulsion and to simultaneously adjust the pH of the water-in-oil emulsion to a range of between 3.5-5.0.

Abstract: An athletic glove comprises a glove body having a substantially planar configuration and which is adapted to be wrapped about the hand, wrist, and arm portions of an arm extremity. First and second rigid brace members are disposed within pockets formed within the glove body for engaging the interior, palm-side of the extremity portions, as well as the exterior, back side of the extremity portions. The two braces operatively cooperate to rigidify the extremity wrist whereby when the extremity undergoes a particular movement, the hand, wrist, and arm portions thereof move in unison. The second brace member may be bent at a central portion thereof in order to fix the disposition of the wrist at a predetermined inclination, and padded fabric may be secured to the interior surface of the glove body for wearing comfort purposes.

Abstract: A composition for insulating or coating tundish materials useful in casting steel which comprises two forms:______________________________________ Broad Medium Preferred (%) (%) (%) ______________________________________ (a) a troweling mix Celite 300 (diatomaceous earth) 5-50 5-25 10.0 200M Mullite (refractory silica-alumina filler) 5-50 10-30 27.0 M&D clay (refractory filler) 2-20 2-15 7.5 Goulac (wood glue) 0.2-5 0.2-2.5 0.5 Cerafiber 312 (silica- alumina fiber) 5-25 5-15 7.5 3216 Graphite (graphite) 1-25 5-20 10.0 Nalgun #2 Binder (colloidal silica binder) 1-30 5-15 7.5 Water 15-50 20-40 30.0 (b) a gunning mix Celite 300 (diatomaceous earth) 5-50 5-25 15.0 200M Mullite (refractory silica-alumina filler) 5-50 10-30 36.8 M&D clay (refractory filler) 2-20 5-15 10.0 Goulac (wood glue) 0.5-5 0.5-2.5 0.7 Cerafiber 312 (silica alumina fiber) 5-25 5-15 10.0 3216 Graphite (graphite) 1-25 5-20 15.0 Nalgun #2 Binder (colloidal silica binder) 1-30 5-15 10.0 Water 1-10 1-5 2.

Abstract: The present invention relates to a support structure for shelves suitable for ready changing of the height and the relative distance between individual shelf boards.The support structure consists of vertical members adapted to be fastened to another vertical structure and of brackets adapted to be moved along the vertical members and to be held therein by frictional locking forces. Each vertical member has a uniform cross section in the shape of a rectangular, assymetrical channel comprising a web, a base flange provided with means for attaching it adjacent to a wall and an outer smaller-width flange provided along its outer with a re-entrant first guide parallel to the plane of the web. Inside the base flange is provided a second guide ridge, which faces the first guide ridge, but at a greater distance from the web than the first guide ridge.

Abstract: A process of pretreating a lower alkyl cellulose, such as ethyl cellulose, which is to be used in microencapsulation of sodium fluoride for dental purposes. This process comprises dispersing a predetermined quantity of lower alkyl cellulose in an aqueous mineral acid, such as HCl, and stirring and aqueous washing of the cellulose such that the pH of the product is adjusted to 6.0 or less. This product is later dissolved in a BTX (benzene, toluene, xylene) solvent such as toluene. Sodium fluoride is added and process steps such as baffle stirring and drying are utilized to produce microencapsulation of the sodium fluoride with the lower alkyl cellulose. The process produces an encapsulating material of optimum sodium content and gives release time in water of 2.3-7.0 hours for the sodium fluoride.

Abstract: 5'-Deoxy-5'-(isobutylthio)-3-deazaadenosine and a method for preparation of same. In the preparation, 3-deazaadenosine is utilized as a starting material and is chlorinated at the 5' position. Subsequently, the chloro group is converted to isobutylthio by reaction with isobutyl mercaptan in ethanol containing sodium methoxide giving the desired compound.A most preferred starting material, i.e., 3-deazaadenosine, was prepared according to the method of Montgomery et al, J. Heterocyclic Chem., 14:195 (1977). The key fusion of this process is 4,6-dichloroimidazo[4,5-c]pyridine with 1,2,3,5-tetra-O-acetyl-.beta.-D-ribofuranose, which, after removal of protective groups and reductive dechlorination of the chlorine at 6, gives 3-deazaadenosine.

Abstract: The Pt compound may be prepared by reacting the known dichloro(1,2-diaminocyclohexane)platinum(II) (NSC 194814) with silver nitrate to replace chloro with nitro. Subsequently, benzene tricarboxylic acid is added to form an off-white precipitate (2 hrs, dark, 5.degree. C.) of the desired product which is preferably utilized as the alkali metal salt.The 4-carboxyphthalato(1,2-diaminocyclohexane)platinum(II) and alkali metal salts thereof may be combined in multiple drug regimen with substantially improved yield cures over the parent compound. For example, the compound denoted Pt-307 may be combined in a dual regimen with cyclophosphamide (CY) and in a triple drug regimen of Pt-307 plus cyclophosphamide (CY) and either 5-fluorouracil (5-FU) or hydroxyurea (HU) as the third component.