Patents Represented by Attorney John W. Wallen

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  • Modified interferon beta polypeptides and their uses
    Patent number: 8329869
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: December 11, 2012
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Anna-Maria A. Hays Putnam, Denise Krawitz, Jason Pinkstaff, Heather Myler
  • Modified animal erythropoietin polypeptides and their uses
    Patent number: 8278418
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provide.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: October 2, 2012
    Assignee: Ambrx, Inc.
    Inventors: Feng Tian, Anna-Maria A. Hays Putnam, Frank Song, Stephanie Chu, Joseph Sheffer, Richard S. Barnett, Marc E. Siladi, Kyle Atkinson, Darin Lee, Peter C. Canning
  • Modified human interferon polypeptides and their uses
    Patent number: 8232371
    Abstract: Modified interferon polypeptides with at least one non-naturally-encoded amino acid and uses thereof are provided.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: July 31, 2012
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Anna-Maria A. Hays Putnam, Troy E. Wilson
  • Methods for expression and purification of recombinant human growth hormone
    Patent number: 8178108
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: May 15, 2012
    Assignee: Ambrx, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Modified human growth hormone formulations with an increased serum half-life
    Patent number: 8178494
    Abstract: Formulations of modified growth hormone polypeptides are provided, including human growth hormone polypeptides with one or more non-naturally encoded amino acids with an increased half-life.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: May 15, 2012
    Assignee: AMBRX, Inc.
    Inventors: Anna-Maria Hays, Ying Buechler, David C. Litzinger
  • Formulations of human growth hormone comprising a non-naturally encoded amino acid
    Patent number: 8163695
    Abstract: Formulations of modified human growth hormone polypeptides are provided.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: April 24, 2012
    Assignee: Ambrx
    Inventors: Anna-Maria A. Hays, Ying Buechler, David C. Litzinger
  • Modified human growth hormone
    Patent number: 8143216
    Abstract: Modified growth hormone polypeptide and uses thereof are provided.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: March 27, 2012
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria A. Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Modified human interferon polypeptides and their uses
    Patent number: 8119603
    Abstract: Modified human interferon polypeptides and uses thereof are provided.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: February 21, 2012
    Assignee: AMBRX, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Anna-Maria Hays, Troy E. Wilson
  • Modified interferon beta polypeptides and their uses
    Patent number: 8114630
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: February 14, 2012
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Anna-Maria A. Hays Putnam, Denise Krawitz, Jason Pinkstaff, Heather Myler
  • Pegylated human interferon polypeptides
    Patent number: 8093356
    Abstract: Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: January 10, 2012
    Assignee: Ambrx, Inc.
    Inventors: Anna-Maria A. Hays, Bruce E. Kimmel, Ho Sung Cho, Bee-Cheng Sim, David C. Litzinger, Roberto Mariani, Vadim Kraynov, Nick Knudsen, Thomas O. Daniel, Alan Koder, Stuart Bussell, Junjie Liu, Zhenwei Miao, Theresa Morrow
  • Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer
    Patent number: 8080391
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: December 20, 2011
    Assignee: AMBRX, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Modified human plasma polypeptide or Fc scaffolds and their uses
    Patent number: 8053560
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: November 8, 2011
    Assignee: Ambrx, Inc.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho
  • Modified human plasma polypeptide or Fc scaffolds and their uses
    Patent number: 8022186
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: September 20, 2011
    Assignee: Ambrx, Inc.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho
  • Modified FGF-21 polypeptides and their uses
    Patent number: 8012931
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: September 6, 2011
    Assignee: Ambrx, Inc.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Ho, Jason Pinkstaff, Vadim Kraynov
  • Azide- or acetylene-terminated poly(alkylene oxide, oxyethylated polyol or olefinic Alcohol)
    Patent number: 8008428
    Abstract: The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: August 30, 2011
    Assignee: Ambrx, Inc.
    Inventor: Troy E. Wilson
  • Methods for expression and purification of recombinant human growth hormone mutants
    Patent number: 7959926
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: June 14, 2011
    Assignee: Ambrx, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Methods for expression and purification of pegylated recombinant human growth hormone containing a non-naturally encoded keto amino acid
    Patent number: 7947473
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: May 24, 2011
    Assignee: AMBRX, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Modified human growth horomone polypeptides and their uses
    Patent number: 7939496
    Abstract: Modified growth hormone polypeptide and uses thereof are provided.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: May 10, 2011
    Assignee: AMBRX, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Modified human plasma polypeptide or Fc scaffolds and their uses
    Patent number: 7919591
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 5, 2011
    Assignee: Ambrx, Inc.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho
  • Compositions of aminoacyl-tRNA synthetase and uses thereof
    Patent number: 7883866
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: February 8, 2011
    Assignee: Ambrx, Inc.
    Inventors: Andrew Paulsel, Ho Sung Cho