Abstract: Sustained release pharmaceutical capsules suitable for oral administration and particularly suitable for sustained release therapy with certain benzodiazepines, e.g. chlordiazepoxide and diazepam, are disclosed. The formulation contained in the disclosed capsules is hydrodynamically balanced to be buoyant in gastric fluid thereby remaining buoyant in the gastric fluid until substantially all of the medicament therein has been released.
Type:
Grant
Filed:
September 19, 1977
Date of Patent:
November 21, 1978
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Prabhakar R. Sheth, Jacques L. Tossounian