Patents Represented by Attorney, Agent or Law Firm Jonathan Provoost
  • Patent number: 6670386
    Abstract: The invention provides compounds of the formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: December 30, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chongqing Sun, Jeffrey A. Robl, Mark E. Salvati, Tammy Wang, Lawrence Hamann, David Augeri
  • Patent number: 6515117
    Abstract: An SGLT2 inhibiting compound is provided having the formula A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or in combination with another antidiabetic agent or other therapeutic agent.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: February 4, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Bruce Ellsworth, William N. Washburn, Philip M. Sher, Gang Wu, Wei Meng
  • Patent number: 6472414
    Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; Rx is H, alkyl, aryl or halogen; A is (1) a bond; (2) —O—; or (3) B is: and wherein L2, L1, R1, R2, R3, R3′, R3a, R3b, R4, R4′, R5, X,  are as defined herein.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: October 29, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, William A. Slusarchyk, Richard B. Sulsky, Joseph A. Tino
  • Patent number: 6262068
    Abstract: Lactam derivatives of the formula where X is —C(═O)NR3′—, —NR3′C(═O)—, —C(═NCN)NR3′—, —NR3′C(═NCN)—, —CH2NR3′—, —CH(alkyl)NR3′—, —CH(COOalkyl)NR3′—, —CH(CH2OH)NR3′—, —C(CH2Oalkyl)—; R1 is halo, alkyl, cycloalkyl, alkyl(cycloalkyl), aryl, (aryl)alkyl, (aryl)alkenyl, (aryl)alkynyl, O-alkyl, O-alkenyl, O-aryl, O-alky(aryl), O-alkyl(heterocyclo), COO-alkyl, C)-alkyl, CO-amino, CO-substituted amino, alkyl-CO-amino, alkyl-CO-substituted amino, NHCO-alkyl, NHCO-aryl, NHCO-alkyl(aryl), NHCO-alkyl(heterocyclo), N(alkyl)CO-alkyl, N(alkyl)CO-aryl, N(alkyl)CO-heterocyclo, N(alkyl)CO-alkyl(aryl), N(alkyl)CO-alkyl(heterocyclo); R2 is hydrogen, alkyl, halo, aryl, (aryl)alkyl, O-alkyl, amino, substituted amino; R3 and R3′ are the same or different and are independently selected from hydrogen, alkyl or alkyl(aryl); R4 which
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: July 17, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Karnail S. Atwal, Saleem Ahmad, Francis N. Ferrara
  • Patent number: 6090859
    Abstract: Small particle size catalysts having an average particle size of less than 20 or 10 microns, which agglomerate when contacted with a hydrocarbon liquid, are easily dispersed in the hydrocarbon liquid by first forming a mixture comprising the catalyst particles and one or more non-acidic, liquid polar oxygenates, such as an alcohol, ketone, ester, ether or mixture thereof. The mixture is contacted with the hydrocarbon liquid in which the particles then readily disperse. This process is useful for adding fresh or regenerated small particle size catalyst to catalytic hydroprocessing process slurries, including a reactive Fischer-Tropsch hydrocarbon synthesis slurry. One to four carbon atom alcohols are preferred oxygenates for use with a Fischer-Tropsch slurry.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: July 18, 2000
    Assignee: Exxon Research and Engineering Co.
    Inventors: Gregg J. Howsmon, Robert J. Wittenbrink, Claude C. Culross, Louis F. Burns
  • Patent number: 6066679
    Abstract: Partially deactivated catalyst in a slurry hydrocarbon synthesis process is rejuvenated employing a cyclic rejuvenation process in which syngas or CO flow into the slurry is stopped to stop the hydrocarbon synthesis reaction, the CO purged out of the slurry with a purge gas in the presence of hydrogen, the catalyst rejuvenated with a hydrogen containing rejuvenating gas and the hydrocarbon synthesis reaction restarted by passing the synthesis gas feed back into the reactor. All or a portion of the purge gas and/or the rejuvenating gas may be recycled during the respective purge and/or rejuvenation. The hydrogen required during the purge is typically part of the purge gas.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: May 23, 2000
    Assignee: Exxon Research and Engineering Company
    Inventors: Stephen C. Leviness, Willard N. Mitchell