Patents Represented by Attorney Joseph C. Wang
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Patent number: 7332640Abstract: The present invention is related to a method for kinetically separating a light hydrocarbon mixture comprising at least two components by preferentially adsorbing a first component on a zeolite adsorbent comprising 8-member rings of tetrahedra as the pore opening controlling hydrocarbon diffusion and alkali metal cations balancing a framework charge, wherein a second component is not preferentially adsorbed. The novel process comprises contacting the light hydrocarbon mixture with a zeolite adsorbent having a SiO2/Al2O3 ratio greater than about 50 and less than 200 and further having a diffusion rate at least 50 times greater for the first component as compared to the second component, and then recovering at least one of the first component or the second component.Type: GrantFiled: October 31, 2003Date of Patent: February 19, 2008Assignee: Exxonmobile Research and Engineering CompanyInventors: Sebastian C. Reyes, David H. Olson, Haiming Liu, Karl G. Strohmaier, Jose G. Santiesteban
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Patent number: 7211666Abstract: Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.Type: GrantFiled: December 22, 2004Date of Patent: May 1, 2007Assignee: Bristol-Myers Squibb CompanyInventors: Jollie Duaine Godfrey, Jr., John Hynes, Jr., Alaric J. Dyckman, Katerina Leftheris, Zhongping Shi, Stephen T. Wrobleski, Wendel William Doubleday, John A. Grosso
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Patent number: 7173042Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.Type: GrantFiled: December 21, 2004Date of Patent: February 6, 2007Assignee: Bristol-Myers Squibb CompanyInventors: Yingzhi Bi, Guixue Yu, David P. Rotella, John E. Macor
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Patent number: 7169771Abstract: The present invention provides thiazolyl-based compounds of formula (I), useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R2, R3, Z1 m and n are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.Type: GrantFiled: February 6, 2004Date of Patent: January 30, 2007Assignee: Bristol-Myers Squibb CompanyInventors: John Hynes, Hong Wu, Katerina Leftheris, Chunjian Liu, Jagabandhu Das, Robert V. Moquin
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Patent number: 7160883Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.Type: GrantFiled: April 22, 2003Date of Patent: January 9, 2007Assignee: Bristol-Myers-Squibb CompanyInventors: Alaric Dyckman, John Hynes, Katerina Leftheris, Chunjian Liu, Stephen T. Wrobleski
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Patent number: 7151113Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.Type: GrantFiled: May 3, 2004Date of Patent: December 19, 2006Assignee: Bristol Myers Squibb CompanyInventors: Alaric J. Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert V. Moquin, Stephen T. Wrobleski
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Patent number: 7148348Abstract: A process is provided for the process for preparing a pyrrolotriazine aniline p38 kinase inhibitor such as amide II by the direct aminolysis of the ester I wherein ester I is reacted with a strong organometallic base, such as hexyllithium or n-butyllithium and the desired amine such as n-propylamine to form the amide II.Type: GrantFiled: August 9, 2005Date of Patent: December 12, 2006Assignee: Bristol-Myers Squibb CompanyInventors: Reginald O. Cann, Edward J. Delaney, Junying Fan, Luca Parlanti
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Patent number: 7034151Abstract: An improved process for the preparation of certain pyrrolotriazine compounds is disclosed. The compounds exhibit utility as kinase inhibitors.Type: GrantFiled: February 5, 2004Date of Patent: April 25, 2006Assignee: Bristol-Myers Squibb CompanyInventors: Bang-Chi Chen, Rulin Zhao, Joseph Edward Sundeen, Katerina Leftheris, John Hynes, Stephen T. Wrobleski
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Patent number: 6984645Abstract: Compounds that are dual aP2/k-FABP inhibitors are provided having the formula wherein A, B, X, Y, R1, R2 and R3 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.Type: GrantFiled: November 15, 2002Date of Patent: January 10, 2006Assignee: Bristol-Myers Squibb CompanyInventors: David R. Magnin, Richard B. Sulsky, Jeffrey A. Robl, Thomas J. Caulfield, Rex A. Parker
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Patent number: 6962915Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts or prodrugs thereof, are useful as kinase inhibitors, wherein Y is —C(?O)NR1—, —NR1C(?O)—, —NR1C(?O)NR1—, —NR1SO2—, —SO2NR1—, —C(?O)—, —OC(?O)—, or —CO2—; B is alkyl, substituted alkyl, alkenyl, substituted alkenyl, hydroxy, alkoxy, aryl, cycloalkyl, heteroaryl, and heterocyclo; or when Y is —C(?O)NR1—, B also may be selected from —C(?O)R8, —C(?O)NR8R9, and —CO2R8; R1 is hydrogen, C1-4alkyl, or substituted C1-4alkyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen, methyl, perfluoromethyl, hydroxy, methoxy, halogen, cyano, NH2, or NH(CH3); and R4, R5, R6, R7, R8, and R9 are as defined in the specification.Type: GrantFiled: May 19, 2003Date of Patent: November 8, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Jagabandhu Das, Chunjian Liu, Robert V. Moquin, Katerina Leftheris
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Patent number: 6919323Abstract: aP2 inhibiting compounds are provided having the formula wherein A, X, R and Z are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing such aP2 inhibitors alone or in combination with other therapeutic agents, including other antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.Type: GrantFiled: July 12, 2002Date of Patent: July 19, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Richard Sulsky, Jeffrey A. Robl
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Patent number: 6906067Abstract: N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-? expression utilizing compounds of the present invention are also disclosed.Type: GrantFiled: June 26, 2001Date of Patent: June 14, 2005Assignees: Bristol-Myers Squibb Company, Pharmaceopeia, Inc.Inventors: Kevin Joseph Moriarty, Yvonne Shimshock, Gulzar Ahmed, Junjun Wu, James Wen, Wei Li, Shawn David Erickson, Jeffrey John Letourneau, Edward McDonald, Katerina Leftheris, Stephen T. Wrobleski, Zahid Hussain, Ian Henderson, Axel Metzger, John J. Baldwin, Alaric J. Dyckman
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Patent number: 6864334Abstract: The instant invention provides a late transition metal complex which can be used with an activating cocatalyst to produce polymers and copolymers. The invention also provides methods for polymerizing olefins, as well as copolymers having polar monomers incorporated therein.Type: GrantFiled: July 16, 2004Date of Patent: March 8, 2005Assignee: ExxonMobil Research and Engineering CompanyInventors: Lisa Saunders Baugh, Abhimanyu Onkar Patil, Donald Norman Schulz, Robert Timothy Stibrany, Joseph Anthony Sissano, Stephen Zushma
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Patent number: 6809058Abstract: The instant invention provides a late transition metal complex which can be used with an activating cocatalyst to produce polymers and copolymers. The invention also provides methods for polymerizing olefins, as well as copolymers having polar monomers incorporated therein.Type: GrantFiled: August 28, 2001Date of Patent: October 26, 2004Assignee: ExxonMobil Research and Engineering CompanyInventors: Lisa Saunders Boffa, Abhimanyu Onkar Patil, Donald Norman Schulz, Robert Timothy Stibrany, Joseph Anthony Sissano, Stephen Zushma
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Patent number: 6777584Abstract: A process for producing a linear &agr;-olefin which comprises: reacting a stoichiometric excess of a terminal Cn olefin with ethylene in the presence of an organometallic catalyst to produce a Cn+2 linear &agr;-olefin, wherein the catalyst is capable of producing a Schulz-Flory distribution of the linear &agr;-olefin with a Schulz-Flory constant of less than about 0.8 and wherein n is an integer between about 3 to 20.Type: GrantFiled: February 22, 2002Date of Patent: August 17, 2004Assignee: ExxonMobil Research and Engineering CompanyInventors: Abhimanyu Onkar Patil, Stephen Zushma, Timothy Daniel Shaffer
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Patent number: 6777514Abstract: The invention is related to a geminally disubstituted olefin-carbon monoxide-ethylene polymer. The invention is also related to a method for preparing geminally disubstituted olefin-carbon monoxide-ethylene polymers by reacting a geminally disubstituted olefin feed, a carbon monoxide feed and an ethylene feed under free radical polymerization conditions. The invention is further related to a geminally disubstituted olefin-carbon monoxide-ethylene-X polymer, where monomer X is a free radical polymerizable monomer. The invention is also directed to a method for preparing geminally disubstituted olefin-carbon monoxide-ethylene-X polymers by reacting a geminally disubstituted olefin feed, a carbon monoxide feed, an ethylene feed and a feed containing monomer X under free radical polymerization conditions. The polymers of the invention are useful as polyvinyl chloride plasticizers.Type: GrantFiled: August 27, 2002Date of Patent: August 17, 2004Assignee: ExxonMobil Research and Engineering CompanyInventors: Abhimanyu O. Patil, Nicholas V. Smith, Jose G. Santiesteban, Allen D. Godwin, Steven P. Rucker, Stephen Zushma
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Patent number: 6750278Abstract: The invention is directed towards a PVC resin composition comprising polyvinyl chloride and a plasticizer selected from the group consisting of: i) a non-linear, paraffin-soluble olefin-CO copolymer; ii) an olefin-CO-X terpolymer derived from non-pure feeds; iii) a non-linear olefin-CO copolymer derived from non-pure feeds; and iv) a non-linear CO-X copolymer; wherein X is selected from the group consisting of alpha-olefin, vinyl acetate, neo vinyl ester and mixtures thereof. The invention also provides a method for a preparing the PVC resin composition as well as a product formed using the PVC resin.Type: GrantFiled: September 10, 2002Date of Patent: June 15, 2004Assignee: ExxonMobil Research and Engineering CompanyInventors: Abhimanyu O. Patil, Donald N. Schulz, Manika Varma-Nair, David J. Lohse, Christine A. Costello, Richard H. Schlosberg, Michael G. Matturro
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Patent number: 6743960Abstract: The present invention is related to a method for oligomerizing olefinic monomers under oligomerization conditions to form higher olefins. The novel method comprises contacting a feed comprising the olefinic monomers with a catalyst composition comprising the reaction product of: (a) a compound having a formula selected from the group consisting of M[S2C2(RaRb)]2 and M[S2C6(R1R2R3R4)]2, wherein M is a late transition metal, Ra, Rb, R1, R2, R3 and R4 are independently selected and may be the same or different and are selected from hydrogen, electron-withdrawing groups and unsubstituted and substituted hydrocarbyl groups; and (b) an activating cocatalyst. The improved method advantageously relates to oligomerizing olefinic monomers from feed streams having contaminants, especially sulfur-containing contaminants.Type: GrantFiled: November 30, 2001Date of Patent: June 1, 2004Assignee: ExxonMobil Research and Engineering CompanyInventors: Kun Wang, Edward Ira Stiefel, Abhimanyu Onkar Patil, Stephen Zushma
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Patent number: 6740718Abstract: The invention relates to a method of forming carbon monoxide-containing polymers from multi-component syngas feeds and at least one vinyl comonomer. Feeds useful in the practice of the invention comprise ethylene in an amount ranging from about 5 to about 40 mole %, carbon monoxide is an amount ranging from about 1 to about 40 mole %, hydrogen in an amount ranging from about 4 to about 55 mole %, carbon dioxide in an amount ranging from about 3 to about 10 mole %, and methane in an amount ranging from about 4 to about 85 mole %. The feed may also include acetylene in an amount ranging up to about 10 mole %. The feed may contain at least one free radical-polymerizable vinyl comonomer, or a cofeed containing such a comonomer can be used.Type: GrantFiled: December 17, 2002Date of Patent: May 25, 2004Assignee: ExxonMobil Research and Engineering CompanyInventors: Abhimanyu O. Patil, Donald N. Schulz, Raymond A. Cook, Michael G. Matturro
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Patent number: 6730757Abstract: The inventions disclosed herein are catalyst systems comprising a complex having one of the formulas LMX1X2 and LML′ and an activating cocatalyst, and use of the catalyst system in polymerizing olefinic monomers. In either of the foregoing formulas, L is a chelating ligand containing sulfur donors; M is a transition metal selected from either copper, silver, gold, manganese, iron, cobalt, palladium or nickel; X1 and X2 are independently selected from either halides, hydride, triflate, acetate, borate, alkyl, alkoxyl, cycloalkyl, cycloalkoxyl, aryl, thiolate, carbon monoxide, cyanate or olefins; and L′ is a bidentate ligand selected from either dithiolene, dithiolate, diphosphine, bisimine, bispyridine, phenanthroline, oxolate, catecholate, thiolatoamide, thiolatoimine or thiolatophosphine.Type: GrantFiled: March 8, 2002Date of Patent: May 4, 2004Assignee: ExxonMobil Research and Engineering CompanyInventors: Kun Wang, Abhimanyu Onkar Patil, Stephen Zushma, Ernestine Williams Hill, Edward Ira Stiefel