Patents Represented by Attorney Joseph Cagno

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  • Aminopterin dosage forms and methods for inflammatory disorders
    Patent number: 7312217
    Abstract: Embodiments of the present invention provide dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Within certain embodiments, the present invention provides a method for treating an inflammatory disorder in a patient with uninterrupted doses of aminopterin.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: December 25, 2007
    Assignee: Syntrix Biosystems, Inc.
    Inventor: John Anthony Zebala
  • Facile process for the preparation of high-purity aminopterin
    Patent number: 7235660
    Abstract: A process for the preparation of aminopterin with a purity greater than 90%, which comprises reacting folic acid, with a silazane in an organic solvent at a temperature from 60 to 180° C., the said solvent being a tertiary amine organic solvent, or, if a catalyst which is acid in nature is present, a basic organic solvent or acetonitrile, and further adding water such that there is about 2.8 to 7.0 mole water for each mole of folic acid.
    Type: Grant
    Filed: January 2, 2007
    Date of Patent: June 26, 2007
    Inventor: John A. Zebala