Patents Represented by Attorney, Agent or Law Firm Joseph F. Reidy
  • Patent number: 6720346
    Abstract: Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: April 13, 2004
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Shao Song Chu, Larry Andrew Alegria, Ted Michael Bleckman, Wesley Kwan Mung Chong, Rohit K. Duvadie, Lin Li, Siegfried Heinz Reich, William Henry Romines, III, Michael B. Wallace, Yi Yang
  • Patent number: 6635641
    Abstract: Amide compounds represented by the formula: wherein: R1 is a moiety represented by the formula  where X is selected from the group consisting of CH2, O, S, and NH; and Y is selected from the group consisting of CH2, O, and S, provided that at least one of X and Y is CH2, or X and Y together with the bond there-between form a cyclopropyl; are described. These compounds and pharmaceutical compositions containing them modulate and/or inhibit the activity of certain protein kinases and are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: October 21, 2003
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Steven Lee Bender, Dilip Bhumralkar, Michael Raymond Collins, Stephen James Cripps, Judith Gail Deal, Lei Jia, Mitchell David Nambu, Cynthia Louise Palmer, Zhengwei Peng, Michael David Varney
  • Patent number: 6620828
    Abstract: Diaminothiazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: September 16, 2003
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Shao Song Chu, Larry Andrew Alegria, Steven Lee Bender, Suzanne Pritchett Benedict, Allen J. Borchardt, Robert Steve Kania, Mitchell David Nambu, Anna Maria Tempczyk-Russell, Sepehr Sarshar, Dilip Bhumralkar, Zhengwei Peng, Michelle Yang
  • Patent number: 6569878
    Abstract: Pharmaceutical compositions containing effective amounts of CDK-inhibiting diaminothiazole compounds of the following formula (where R1 and R2 are as defined in the specification) or their salts, or prodrugs or active metabolites of such compounds or salts, are useful for treating disorders and diseases such as cancer: In preferred embodiments, R1 and R2 are independently unsubstituted or substituted carbocyclic or heterocyclic aryl ring structures. Compounds where R2 is ortho-substituted aryl are especially potent inhibitors of CDKs such as CDK4.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: May 27, 2003
    Assignee: Agouron Pharmaceuticals Inc.
    Inventors: Wesley K. M. Chong, Shao Song Chu, Lin Li, Rohit K. Duvadie, Yi Yang, Wei Xiao
  • Patent number: 6555539
    Abstract: Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: April 29, 2003
    Assignee: Agouron Pharmaceuticals
    Inventors: Siegfried Heinz Reich, Ted Michael Bleckman, Susan Elizabeth Kephart, William Henry Romines, Michael B. Wallace
  • Patent number: 6531491
    Abstract: Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: March 11, 2003
    Assignee: Agouron Pharamaceuticals, Inc.
    Inventors: Robert Steven Kania, Steven Lee Bender, Allen J. Borchardt, Stephan James Cripps, Cynthia Louise Palmer, Anna Maria Tempczyk-Russell, Michael David Varney, Michael Raymond Collins
  • Patent number: 6448322
    Abstract: Halogenated isobutylene-p-methylstyrene polymers are stabilized against discoloration with a weak base such as 100 to 500 ppm sodium bicarbonate. The additive is added to the rubbery polymers after dewatering in the finishing step of their manufacture. The curability of the stabilized rubbers is not adversely affected by the sodium bicarbonate additive.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: September 10, 2002
    Assignee: Exxon Mobil Chemical Patents Inc.
    Inventors: Richard C. Yeh, David Yen-Lung Chung, Chia Shian Chee
  • Patent number: 6326433
    Abstract: The improved green strength, green elongation, and green relaxation properties of isobutylene based elastomers at elevated temperatures along with improved aging and barrier properties are achieved by blending semi-compatible, semi-crystalline polymers with the isobutylene elastomers. The improved properties are maintained in subsequent rubber compounds containing said blends and are particularly useful in tire and pharmaceutical container applications.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: December 4, 2001
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Hsien-Chang Wang, Ilan Duvdevani, Sudhin Datta, Connie R. Qian
  • Patent number: 6300431
    Abstract: A process for catalytic recovery in a phase transfer process wherein heterogeneous reactions in a liquid-liquid two phase reaction systems using a phase transfer catalyst is improved by separating the two liquid phases with a membrane which retains the catalyst while passing the aqueous polar liquid thereby allowing easy recovery of the phase transfer catalyst. The reaction is carried out between reactants selectively soluble in the different phases, one of the reactants being transferred into the other phase by means of a phase transfer catalyst which is soluble in said polar liquid phase with the one reactant. The phases are separated after completion of the reactions by adding water to the two-phase reaction system to dissolve out the polar liquid phase containing the phase transfer catalyst into an aqueous phase.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: October 9, 2001
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Hsien-Chang Wang, Chia Shian Chee, W. S. Winston Ho
  • Patent number: 6294613
    Abstract: A compatibilized blend of general purpose rubbers (GPR) and polymers containing benzylic halide groups are produced through solventless reactions utilizing a multifunctional agent containing a diene reactive group and a benzylic halo reactive group.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: September 25, 2001
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventor: Anthony Jay Dias
  • Patent number: 6291389
    Abstract: A cationic catalyst composition comprising a reactive cation and a compatible non-coordinating anion is preferably used at a temperature of 20° C. or less to produce olefin polymers, particularly polymers and copolymers of isobutylene.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: September 18, 2001
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Timothy Daniel Shaffer, Anthony Jay Dias, Ira David Finkelstein, Myron Bernard Kurtzman
  • Patent number: 6274689
    Abstract: The invention provides a copolymer of an isomonoolefin having from 4 to 7 carbon atoms and containing a copolymerized alkenyl styrene moiety represented by the formula I: where m=0-2, n=0-20, each of R1 through R7 are independently selected from the group consisting of hydrogen, C1 to C10 alkyl and C1 to C10 primary or secondary alkyl halides, and at least one of R1, R2 or R3 is hydrogen, and when m=1 or 2, R3 and R1 are —CH2—.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: August 14, 2001
    Assignee: Exxon Chemical Patents, Inc.
    Inventors: Timothy Daniel Shaffer, David Yen-Lung Chung
  • Patent number: 6265486
    Abstract: Novel triblock copolymers are provided. The triblock copolymers have a midblock which is a copolymer of an isoolefin monomer and a vinyl aromatic monomer. Preferably, the midblock is a copolymer of isobutylene and alkylstyrene. The end blocks of the triblock copolymer are either a homopolymer of a vinyl aromatic monomer or a copolymer of two or more monomers selected from the group consisting of vinyl aromatics, styrene, methylstyrene, butylstyrene, halostyrene, p-allylstyrene and p-3-butenylstyrene. In addition, a process is provided for preparing a triblock copolymer.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: July 24, 2001
    Assignee: Exxon Mobil Chemical Patents Inc.
    Inventors: Timothy Daniel Shaffer, Hsien-Chang Wang
  • Patent number: 6255426
    Abstract: A polymer of ethylene and at least one alpha olefin having at least 5, carbon atoms obtainable by a continuous gas phase polymerization using supported catalyst of an activated molecularly discrete catalyst such as a metallocene in the substantial absence of an aluminum alkyl based scavenger which polymer has a Melt Index (MI) as herein defined of from 0.1 to 15; a Compositional Distribution Breadth Index (CDBI) as defined herein of at least 70%, a density of from 0.910 to 0.930 g/ml; a Haze value as herein defined of less than 20%; a Melt Index ratio (MIR) as herein defined of from 35 to 80; an averaged Modulus (M) as herein defined of from 20 000 to 60 000 psi (pounds per square inch) and a relation between M and the Dart Impact Strength in g/mil (DIS) complying with the formula: DIS≧0.8×[100+e(11.71−0.000268×M+2.183×10−9×M2)].
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: July 3, 2001
    Assignee: Exxon Chemical Patents, Inc.
    Inventors: Ching-Tai Lue, Natalie A. Merrill, Michael E. Muhle, George Alan Vaughan
  • Patent number: 6232418
    Abstract: This invention relates to novel resins, blends of the novel resins with base polymers and a process for producing a resin comprising combining a reactor feed blend comprising: (a) at least 2 weight % of isoprene, (b) at least 2 weight % of one or more of dicyclopentadiene, substituted cyclopentadienes and substituted dicyclopentadienes, (c) at least 2 weight % piperylene, (d) at least 1 weight % aromatic olefins, and (e) 0 to 92 weight % of additional aliphatic olefins, based upon the weight of the reactor feed blend, with a polymerization catalyst under polymerization conditions, preferably where the ratio of component (c) to component (b) is less than 8 and the ratio of component (a) to component (b) is less than 5.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: May 15, 2001
    Assignee: Exxon Mobile Chemical Patents, INC
    Inventors: Anne Vera Macedo, Martijn Hendrik Willem Burgers, Leonor Ma Garcia, Lutz Erich Jacob, Jozef Aleida Florent Smits, R. Derric Lowery, Jerry Lee Haluska, Charles L. Sims, Frank Carl Jagisch
  • Patent number: 6232416
    Abstract: The invention addresses Group 5 metal compounds suitable as polymerization catalysts characterized by comprising one Group 15 element polyanionic ancillary ligand and three single or multidentate univalent ligands comprising Group 14-16 elements bound to the Group 5 metal, but excluding cyclopentadienyl ligands. The invention Group 5 metal compounds can be generically represented by the chemical symbols [RJ]MR′3,   (1) and [(RJ)Yn(X)]MR′2  (2) where M is a Group 5 transition metal, preferably vanadium; J is a Group 15 heteroatom ligand covalently bound to M, preferably nitrogen; R is a substituted or unsubstituted aryl, hydrocarbyl or organometalloid group covalently bound to J; each R′ is, independently, a uninegative ligand, e.g.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: May 15, 2001
    Assignee: Exxon Mobil Chemical Patents Inc.
    Inventors: Howard William Turner, Vincent John Murphy
  • Patent number: 6228978
    Abstract: Polyisobutylene (PIB) functionalized with terminal reactive unsaturation is disclosed. Carbocationically polymerized monohalogen-terminated PIB is dehydrohalogenated in a hydrocarbon solvent using an alkoxide of the formula RO-M wherein R is alkyl of at least 5 carbon atoms and M is alkali metal. The PIB obtained has terminal unsaturation which is 100% in the reactive ‘exo’ form which can be converted to succinic anhydride groups (PIB-SA) by the ene reaction with maleic anhydride. The PIB-SA is reactive with amine functional dendrimers to obtain a star-branched polymer having a dendrimer core and PIB branches joined by succininide linkages. Blends of the star-branched polymer with polypropylene have improved energy absorption properties and controllable moisture/oxygen permeabilities useful in films.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: May 8, 2001
    Assignee: Exxon Mobil Chemical Patents Inc
    Inventors: Pawan Kumar Agarwal, Hsien-Chang Wang, Yu Feng Wang, Jean M. J. Frechet, Shah A. Haque
  • Patent number: 6184170
    Abstract: This invention relates generally to metallocene catalyst systems and to methods for their production and use. Specifically, this invention relates to a method for preparing metallocene catalyst systems using olefin additives which promote catalyst activity.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: February 6, 2001
    Assignee: Exxon Chemical Patents, Inc.
    Inventor: Main Chang
  • Patent number: 6180736
    Abstract: The disclosed invention relates to a polymerization process comprising contacting ethylene, and optionally, one or more olefinically unsaturated comonomers, with an active supported Group 3, 4, 5, or 6 metallocene catalyst system having an unsubstituted or substituted fused-ring cyclopentadienyl ligand, preferably indenyl or fluorenyl, and a substituted or unsubstituted cyclopentadienyl ligand under gas-phase or slurry polymerization conditions. The process is suitable for the production of high-density polyethylene homopolymers and copolymers. The benefits to industrial practice are both the ease of preparation and low-cost of the precursor metallocene compound and the commercially feasible polymerization activity levels in stable, low fouling level reactor conditions surprisingly associated with it. Additionally, the polymers made under the invention process conditions have narrow molecular weight distributions, low MI, and low values for MIR.
    Type: Grant
    Filed: December 17, 1997
    Date of Patent: January 30, 2001
    Assignee: Exxon Chemical Patents Inc
    Inventors: Michael E. Muhle, George Alan Vaughan
  • Patent number: H2058
    Abstract: The present invention provides cocatalysts for activating metallocene complexes in olefin polymerization reactions, and metallocene catalyst systems using the cocatalysts. The cocatalysts of the present invention include: (a) a halo-organoaluminum compound of the formula AlnRmX3n-m, where Al is aluminum, each R is independently a Cl to C4 alkyl group, X is a halide, n is 1 or 2, and m is determined by the valency of Al; and (b) a dialkylmagnesium compound of the formula MgR′2, where Mg is magnesium and R′ is a C2 to C6 alkyl group. The components (a) and (b) are used in amounts such that the molar ratio of Al:Mg is at least 2, preferably from 2:1 to 5:1.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: January 7, 2003
    Assignee: Mobil Oil Corporation
    Inventors: A. J. Brandolini, Yury Viktorovich Kissin, Robert Ivan Mink, Thomas E. Nowlin