Patents Represented by Attorney Joseph M. Skerpon

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  • Protein kinase C inhibitors
    Patent number: 5696108
    Abstract: This invention provides novel bis-indolemaleimide macrocycle derivatives of the formula: ##STR1## The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals.
    Type: Grant
    Filed: May 6, 1996
    Date of Patent: December 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: William F. Heath, Jr., Michael R. Jirousek, John H. McDonald, III, Christopher J. Rito
  • Reducing gelation of a fatty acid-acylated protein
    Patent number: 5631347
    Abstract: A method for processing a fatty acid-acylated protein, especially N-palmitoyl Lys.sup.B29 human insulin, to reduce the incidence of gelation by conducting such processing in the presence of a citrate buffering agent as the primary buffer which method allows such processing to be conducted at higher protein concentrations and with less temperature control than would otherwise be possible in the absence of the citrate buffer.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 1997
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey C. Baker, Jose M. Hanquier, Warren E. Shrader
  • Zearalanol derivatives with anabolic activity
    Patent number: 4849447
    Abstract: Compounds having the formula: ##STR1## wherein R.sub.1 is hydrogen, or an alkyl from about 1 to about 3 carbon atoms; R.sub.2 is hydrogen, or an alkyl from about 1 to about 18 carbon atoms; R.sub.3 is keto, or hydroxyl; and R.sub.4 is hydrogen, an alkyl from about 1 to about 4 carbon atoms, hydroxyl, or amino are synthesized and administered to animals as anabolic agents.
    Type: Grant
    Filed: October 13, 1987
    Date of Patent: July 18, 1989
    Assignee: Pitman-Moore, Inc.
    Inventor: Martin J. Jacobs
  • Flotation process for recovery of phosphate values from ore
    Patent number: 4737273
    Abstract: A process for recovering phosphate values from silica-containing phosphate ores is provided. The ore has a particle size in the range of about 0.6 to 1.2 mm and is subjected to selective flotation in the presence of a cationic flotation reagent comprising a di(hydrophobic group) quaternary ammonium salt, wherein each of the hydrophobic groups contain 6 or more carbon atoms and at least one of the groups contains from about 10-20 carbon atoms, in combination with a hydrocarbon oil and a phosphate depressing agent.
    Type: Grant
    Filed: January 3, 1986
    Date of Patent: April 12, 1988
    Assignee: International Minerals & Chemical Corp.
    Inventor: Robert E. Snow
  • Electrodialysis process for preparing hydrogen fluoride
    Patent number: 4599156
    Abstract: Hydrogen fluoride is produced by the electrodialysis of an alkali metal fluoride salt solution or an ammonium fluoride solution in an electrodialysis cell having an anode compartment and a cathode compartment spaced from one another by an inner electrodialysis compartment bounded by spaced cation exchange membranes.
    Type: Grant
    Filed: September 27, 1985
    Date of Patent: July 8, 1986
    Assignee: International Minerals & Chemical Corp.
    Inventors: Viswanathan Srinivasan, Carl O. Quicksall