Abstract: The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding Gibbon Ape Leukemia Virus (GALV) receptor. Differences in the type of retroviruses interacting with the receptors exist. The protein encoded by the GLVR2, cells transformed or transfected by the gene, and vectors containing the gene are also disclosed.
Type:
Grant
Filed:
April 16, 1993
Date of Patent:
August 27, 1996
Assignee:
American Cyanamid Company
Inventors:
Stephen V. Johann, Marja van Zeijl, Bryan M. O'Hara