Abstract: This invention relates to the use of amine, amino acid and amino acid ester mobile modifiers in normal phase chromatography to improve the resolution and or productivity of peptide and lipopeptide purification. This chromatographic method can be sued for either analytical or preparative scale purification.
Type:
Grant
Filed:
October 24, 2003
Date of Patent:
July 10, 2007
Assignee:
Merck & Co., Inc.
Inventors:
Kent E. Goklen, Joseph Nti-Gyabaah, Firoz D. Antia, Mary Ellen Dahlgren