Abstract: Methods for the sequencing of polynucleotides are provided. Also provided are multiplex systems for sequencing polynucleotides using the disclosed methods, kits for use with the disclosed methods and methods for diagnosing diseases and adverse drug reactions using the disclosed methods.
Type:
Grant
Filed:
May 30, 2003
Date of Patent:
November 6, 2007
Assignee:
Verenium Corporation
Inventors:
Mike Lafferty, Charles Tweedy, James Butler
Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II:
and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
Type:
Grant
Filed:
October 26, 2000
Date of Patent:
March 19, 2002
Assignee:
Bristol-Myers Squibb Pharma Company
Inventors:
Liqi He, Paul Gilligan, Robert Chorvat, Argyrios Georgios Arvanitis
Abstract: The present invention provides improved oral dosage form formulations of efavirenz that are useful in the inhibition of human immunodeficiency virus (HIV), the prevention or treatment of infection by HIV, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS). In particular, the present invention relates to compressed tablets or capsules comprising efavirenz that contain one or more disintegrants that enhance the dissolution rate of the efavirenz in the gastrointestinal tract thereby improving the rate and extent of absorption of efavirenz in the body. The present invention also relates to the process of making such tablets or capsules.
Type:
Grant
Filed:
April 6, 1999
Date of Patent:
May 29, 2001
Assignee:
DuPont Pharmaceuticals Company
Inventors:
William T. Makooi-Morehead, John D. Buehler, Brian R. Landmann