Abstract: The invention relates to a method of treating neurological disorders associated with neurotransmitter deficit in a mammal comprising administering to the mammal a therapeutically effective amount of a combination of: (i) at least one neurotransmitter release enhancer, and (ii) at least one acetylcholinesterase inhibitor. The invention also relates to compositions and kits containing the same.
Abstract: Novel compounds and pharmaceutical compositions thereof, and methods of using same in treating anxiety, depression, and other psychiatric and neurological disorders. The novel compounds provided by this invention are those of the following formulae:
wherein R1, R13, X, Y, Z, G and Q are as defined herein.
Type:
Grant
Filed:
March 3, 2000
Date of Patent:
July 10, 2001
Assignee:
DuPont Pharmaceuticals Company
Inventors:
Parthasarathi Rajagopalan, Robert John Chorvat, Rajagopal Bakthavatchalam, James Peter Beck, Paul Joseph Gilligan, Richard Eric Olson
Abstract: Corticotropin releasing factor (CRF) antagonists of Formula (I):
and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.
Type:
Grant
Filed:
September 1, 1998
Date of Patent:
June 12, 2001
Assignee:
DuPont Pharmaceuticals Company
Inventors:
Argyrios G. Arvanitis, Paul J. Gilligan, James P. Beck, Rajagopal Bakthavatchalam