Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to TNF?.
Type:
Grant
Filed:
September 12, 2008
Date of Patent:
July 12, 2011
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: The invention proposes a particulate filter having a catalytic coating which contains two catalysts arranged one behind the other. The first catalyst is located in the gas inlet region of the filter and contains a palladium/platinum catalyst. The second catalyst is arranged downstream of the first catalyst and preferably contains platinum alone as catalytically active component. The combination of these two catalysts provides the coated filter with a good ageing stability and resistance to sulphur poisoning.
Type:
Grant
Filed:
August 13, 2005
Date of Patent:
July 12, 2011
Assignee:
Umicore AG & Co. KG
Inventors:
Marcus Pfeifer, Markus Koegel, Roger Staab, Pascal Adolph, Yvonne Demel, Tobias Kuhl, Egbert Lox, Thomas Kreuzer, Frank-Walter Schuetze
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to MYC.
Type:
Grant
Filed:
June 16, 2009
Date of Patent:
May 31, 2011
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
Type:
Grant
Filed:
April 12, 2010
Date of Patent:
May 3, 2011
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: A diesel particulate filter with an oxidation catalyst comprising platinum and palladium deposited thereon is described. Addition of HC storage components to the oxidation catalyst allows the conversion of hydrocarbons and carbon monoxide to be improved significantly.
Type:
Grant
Filed:
August 17, 2007
Date of Patent:
April 12, 2011
Assignee:
Umicore AG & Co. KG
Inventors:
Markus Koegel, Marcus Pfeifer, Gerald Jeske, Frank Walter Schuetze, Stéphanie Frantz, Thomas Kreuzer
Abstract: Nitrogen oxide storage catalytic converters for purifying the exhaust gas of lean-burn engines are periodically regenerated by switching the engine from lean-burn mode to rich-burn mode. After regeneration has taken place, the engine is switched back to lean-burn mode. At this time, rich exhaust gas is still flowing in the exhaust line from the engine to the catalytic converter, which rich exhaust gas is ejected via the catalytic converter into the environment by the following, lean exhaust gas. This leads to brief emissions peaks of the rich exhaust gas constituents and impairs the level of exhaust gas cleaning which can be obtained. In order to solve said problem, it is proposed to create oxidizing conditions by injecting air upstream of the storage catalytic converter, so that the rich exhaust gas constituents still flowing in the exhaust line upstream of the storage catalytic converter can be converted at the storage catalytic converter to form non-harmful products.
Type:
Grant
Filed:
June 22, 2006
Date of Patent:
March 15, 2011
Assignee:
Umicore AG & Co. KG
Inventors:
Ulrich Goebel, Stephan Bremm, Christian Manfred Tomanik, Wilfried Mueller, Thomas Kreuzer
Abstract: The present invention relates to an exhaust gas cleaning catalyst comprising on a honeycomb carrier a catalytic coating. Said honeycomb carrier has an upstream end and a downstream end and a plurality of flow channels are running from the upstream end to the downstream end. The catalytic coating comprises catalytically active precious metal components of which at least one component exhibits a concentration profile along the honeycomb carrier starting with a low concentration at the upstream end which increases along the flow channels up to a maximum value and then decreases again to the downstream end.
Type:
Grant
Filed:
January 18, 2005
Date of Patent:
March 15, 2011
Assignee:
Umicore AG & Co. KG
Inventors:
Anke Wolf, Dieter Lindner, Matthias Feger, Martin Roesch, Egbert Lox, Thomas Kreuzer
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
Type:
Grant
Filed:
September 11, 2009
Date of Patent:
March 1, 2011
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Type:
Grant
Filed:
November 23, 2009
Date of Patent:
February 22, 2011
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe, Steven Read
Abstract: In a first embodiment the invention relates to a process for producing a dispersoid-strengthened material, comprising the steps of: (i) providing metal particles, wherein the metal is selected from platinum group metals, gold, silver, nickel and copper, as well as alloys thereof; (ii) mixing the metal particles with a precursor compound of the dispersoid and solvent; (iii) removing the solvent, so as to obtain metal particles provided with precursor compound; and (iv) compacting the metal particles provided with precursor compound in order to obtain the dispersoid-strengthened material, wherein the precursor compound is converted into the dispersoid during the compacting operation.
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
Type:
Grant
Filed:
September 17, 2009
Date of Patent:
December 21, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to CTGF.
Type:
Grant
Filed:
December 23, 2009
Date of Patent:
November 16, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Type:
Grant
Filed:
March 30, 2005
Date of Patent:
November 16, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe
Abstract: Methods and compositions for performing RNA interference with decreased off-target effects are provided. The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications comprise 2?-O-alkyl or mismatch modification(s) at specific positions on the sense and/or antisense strands.
Type:
Grant
Filed:
September 19, 2007
Date of Patent:
November 16, 2010
Assignee:
Dharmacon, Inc.
Inventors:
Devin Leake, Angela R Reynolds, Anastasia Khvorova, William Marshall