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  • High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications
    Patent number: 5989554
    Abstract: A process for producing and purifying peptides and for producing peptide/protein antigens for antibody production is described. The process utilizes fusion proteins and specifically fusion proteins in which the fusion protein carrier segment includes an amino acid sequence at least about 65 amino acids long and in which the amino acid sequence does not contain negative or positive charged side chains of amino acids.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: November 23, 1999
    Assignee: Promega Corporation
    Inventors: Mark W. Knuth, Mary Haak-Frendscho, John W. Shultz, Scott A. Lesley, Catherine E. Villars