Abstract: The invention provides isolated placental P. falciparum polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-4 and 6-24, and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the placental P. falciparum polypeptides of the invention, compositions comprising one or more placental P. falciparum polypeptides of the invention, methods for inducing an immune response against the placental P. falciparum polypeptides, and methods for treating and diagnosing placental malaria.
Type:
Grant
Filed:
December 8, 2009
Date of Patent:
September 6, 2011
Assignees:
Seattle Biomedical Research Institute, The United States of America as represented by the Secretary of the Army
Inventors:
Michal Fried, Patrick E Duffy, Susan Francis, Jason P Wendler, Theonest K Mutabingwa, Andrew Oleinikov
Abstract: The invention provides isolated placental P. falciparum polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-4 and 6-24, and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the placental P. falciparum polypeptides of the invention, compositions comprising one or more placental P. falciparum polypeptides of the invention, methods for inducing an immune response against the placental P. falciparum polypeptides, and methods for treating and diagnosing placental malaria.
Type:
Grant
Filed:
January 3, 2008
Date of Patent:
February 2, 2010
Assignees:
Seattle Biomedical Research Institute, The United States of America as represented by the Army
Inventors:
Michal Fried, Patrick E. Duffy, Susan Francis, Jason P. Wendler, Theonest K. Mutabingwa, Andrew Oleinikov