Patents Represented by Attorney Karen G. Kaiser
  • Patent number: 5616602
    Abstract: A topically administrable pharmaceutical composition comprising (A) zinc phthalocyanine complex, (B) as carrier for the complex, (i) a N-alkylpyrrolidone together with a pharmaceutically acceptable co-solvent for the complex, (ii) dimethyl sulphoxide or a mixture thereof with a pharmaceutically acceptable co-solvent for the complex, (iii) a liposome, or (iv) a N,N-dialkylbenzamide or a mixture thereof with a pharmaceutically acceptable co-solvent for the complex, and (C) a gelling agent.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: April 1, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter W. Taylor, William G. Love, Brigitte C. H. van der Zanden
  • Patent number: 5612340
    Abstract: N-phenyl-2-pyrimidineamine derivatives of formula (I) wherein the substituents are as defined in claim 1 are described. Those compounds can be used for example, in the treatment of tumour diseases.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: March 18, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: J urg Zimmermann
  • Patent number: 5610195
    Abstract: Compounds of formula (I) in which (a) four of the radicals R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen and the others independently of one another are in each case C.sub.1 -C.sub.2 alkyl, these groups being bonded to the same carbon atom or to two different carbon atoms, or (b) five of the radicals R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen and the other radical is C.sub.1 -C.sub.2 alkyl or hydroxymethyl, or salts thereof, are described. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: March 11, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: J org Frei, Jaroslav Stanek
  • Patent number: 5605663
    Abstract: The invention relates to novel aromatic acids, especially to compounds of formula ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is lower alkyl, R.sub.3 is hydrogen, carboxy or sulfo, R.sub.4 is carboxy or sulfo, G is an unsubstituted or substituted 1,4-phenylene group or an unsubstituted or substituted 1,4-naphthylene group, and wherein either R.sub.5 and R.sub.6 together are an additional bond and L is an oxygen or sulfur atom or wherein R.sub.5 is hydrogen, R.sub.6 is halomethyl and L is an oxygen atom, and salts thereof, to the use of compounds I and their salts, to a process for the preparation of compounds I and their salts, to starting materials used in that preparation process, and salts thereof, to a process for the preparation of those starting materials and their salts, to a device in which the compounds I and their salts are used, and to a process in which that device is used.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 25, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Jui Y. Chang
  • Patent number: 5602178
    Abstract: A method of achieving a relaxing, invigorating, tingling bath in the substantial absence of a menthol aroma, comprising incorporating into said bath a bath product formulation comprising menthyl lactate in an amount of about 0.5% to about 15% by weight of said formulation together with a bath product suitable carrier therefor.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: February 11, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Robert Caroselli, Theodore Clemente, Jr., Sandra E. Sandbeck
  • Patent number: 5599569
    Abstract: A method for adhering seasoning to a food product comprising the steps of:a) coating the food product with a solution containing an effective amount of an amylase treated starch;b) adhering thereon at least one seasoning, flavorant, or colorant; andc) drying the resultant food product;the amylase treated starch having been prepared by steam cooking starch, and enzymatically hydrolyzing said cooked starch with amylase in an amount and for a sufficient time to achieve a funnel viscosity (measured at 19% solids using a standard funnel) of 7 to 80 seconds, and a dextrose equivalent (DE) of 2 to 40.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: February 4, 1997
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Chung-Wai Chiu, David P. Huang, James J. Kasica, Zu-Feng Xu
  • Patent number: 5593962
    Abstract: The invention provides fibrillated calcitonin for use in treating calcium deficiency diseases.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: January 14, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Tudor Arvinte, Amelia Cudd, Judith Phillips
  • Patent number: 5591154
    Abstract: This invention discloses that styrene-butadiene-styrene block copolymers containing 30 to 50% by weight styrene and additionally having been polymerized in such a manner as to obtain a vinyl content of greater than about 35% may be used in adhesives to achieve desirable low viscosity of 1000 to 3500 cps at 160.degree. C.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: January 7, 1997
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Karen Dare, Martin Riswick, Gary F. Raykovitz, Charles W. Paul
  • Patent number: 5587461
    Abstract: The invention relates to novel aromatic acids, especially to compounds of formula ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is lower alkyl, R.sub.3 is hydrogen, carboxy or sulfo, R.sub.4 is carboxy or sulfo, G is an unsubstituted or substituted 1,4-phenylene group or an unsubstituted or substituted 1,4-naphthylene group, and wherein either R.sub.5 and R.sub.6 together are an additional bond and L is an oxygen or sulfur atom or wherein R.sub.5 is hydrogen, R.sub.6 is halomethyl and L is an oxygen atom, and salts thereof, to the use of compounds I and their salts, to a process for the preparation of compounds I and their salts, to starting materials used in that preparation process, and salts thereof, to a process for the preparation of those starting materials and their salts, to a device in which the compounds I and their salts are used, and to a process in which that device is used.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: December 24, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Jui Y. Chang
  • Patent number: 5583128
    Abstract: The invention relates to the use of aromatase inhibitors for contraception in female primates and to a method for contraception in female primates using such substances and to the use of those substances for the preparation of pharmaceutical compositions for contraception in female primates.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: December 10, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Ajay Bhatnagar
  • Patent number: 5571788
    Abstract: A stable aqueous solution of human calcitonin (hCT) which remains free of hCT fibrils for at least 24 hours at 25.degree. C. which comprises water, hCT and a cellulose derivative and/or an acid, the type of acid and the amount of acid being so chosen as to achieve said stability in the absence of a salt or a buffer.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: November 5, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Tudor Arvinte, Katherine D. Ryman
  • Patent number: 5562937
    Abstract: A formulated starch-containing food product characterized by improved mouth-feel and texture is prepared from a mixture of non-starch ingredients together with a beta-amylase or glucoamylase treated waxy starch which has been prepared by a process which comprises steam cooking a starch slurry at a temperature of 120.degree. to 170.degree. C. to completely gelatinize the waxy starch; enzymatically hydrolyzing the gelatinized starch with beta-amylase or glucoamylase until up to about 60% by weight of the starch has been degraded to maltose or glucose; terminating the enzyme degradation by deactivating the enzyme and recovering the starch by spray drying.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: October 8, 1996
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Jamie Senkeleski, Chung-Wai Chiu, Zu-Feng Xu, William R. Mason, Karen L. Chicalo-Kaighn
  • Patent number: 5559111
    Abstract: .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: September 24, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Richard G oschke, J urgen K. Maibaum, Walter Schilling, Stefan Stutz, Pascal Rigollier, Yasuchika Yamaguchi, Nissim C. Cohen, Peter Herold
  • Patent number: 5545631
    Abstract: Compounds having GABA.sub.B -antagonistic properties, for example those of formula I ##STR1## wherein one of the radicals R.sub.1, R.sub.2 and R.sub.3 is hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another is hydrogen or, in the case of R.sub.1 or R.sub.2, hydroxy or, in the case of R.sub.1, halogen or, in the case of R.sub.2 together with R.sub.2 ', oxo, and the remaining radical is hydrogen, R.sub.1 ' is hydrogen or halogen, R.sub.2 ' is hydrogen, hydroxy or, together with R.sub.2, is oxo, R.sub.4 and R.sub.5 are hydrogen or R.sub.4 is an araliphatic or heteroarylaliphatic radical and R.sub.5 is hydrogen or an aliphatic radical, and R is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic, heteroarylaliphatic or aromatic radical having at least 2 carbon atoms or, when R.sub.1 is hydrogen or hydroxy, R.sub.2 is an aromatic radical and R.sub.1 ', R.sub.2 ' and R.sub.3 are hydrogen.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: August 13, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Christian Marescaux, Raymond Bernasconi, Markus Schmutz, Wolfgang Fr ostl, Stuart J. Mickel
  • Patent number: 5543520
    Abstract: There are disclosed N-(fluoroalkoxyphenyl)-2-pyrimidine-amine derivatives of formula I ##STR1## wherein R.sub.1 is isoquinolinyl, thienyl or 1H-pyrrolyl, and R.sub.2 is fluoro-substituted alkoxy containing up to 2 carbon atoms. These compounds can be used, inter alia, for the therapy of tumoral diseases.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: August 6, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: J urg Zimmermann
  • Patent number: 5541195
    Abstract: 1-Acylpiperidine compound of the formula I ##STR1## in which R.sub.1 is an optionally substituted aralkyl, aryloxyalkyl, heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl radical or the acyl radical of an .alpha.-amino acid which is optionally N-substituted by lower alkanoyl or carbamoyl-lower-alkanoyl, R.sub.2 is cycloalkyl or an optionally substituted aryl or heteroaryl radical, R.sub.3 is hydrogen, alkyl, carbamoyl or an alkanoyl or alkenoyl radical which is optionally substituted by carboxyl or esterified or amidated carboxyl, R.sub.4 is an optionally substituted aryl or optionally partially hydrogenated heteroaryl radical, X.sub.1 is methylene, ethylene, a direct linkage, an optionally ketalised carbonyl group or an optionally etherified hydroxymethylene group, X.sub.2 is alkylene, carbonyl or a direct linkage, and X.sub.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: July 30, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Walter Schilling, Silvio Ofner, Siem J. Veenstra
  • Patent number: 5536265
    Abstract: A light diffuser for the radial emission of light, which has been fed into the diffuser in axial direction, comprises an optical waveguide, which itself comprises a core and a cladding. The core of the waveguide is exposed at an active region at the distal end. The exposed active region of the core is optically separated from a substance containing scattering particles. In a preferred embodiment, the core is roughened and is embedded in a first layer of an elastic substance, which has a refractive index similar to the refractive index of the cladding and which does not contain any scattering particles. This first layer is embedded in at least one further, second layer of an elastic substance comprising the scattering particles. This substance is surrounded by the outer tube.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: July 16, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Hubert van den Bergh, Jerome Mizeret
  • Patent number: 5532287
    Abstract: This invention pertains to cross-linked hydrophilic polymeric films, the process of making such films, and their use. The films of this invention are produced by solubilizing a water-soluble polymer with a photosensitive or light degradable catalyst, optionally drying said solution, and exposing the solution to an energy source, particularly light. These films are suitable for use as a carrier for biologically active agents, such as pharmaceuticals, both human and veterinary, insecticides, and fertilizers; as hydrophilic membranes for separation processes; as bandages for wound treatment; as body implants or as coatings for such implants; and as coatings on glass, metal, wood or ceramics.
    Type: Grant
    Filed: May 4, 1994
    Date of Patent: July 2, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Gary V. Savage, James M. Clevenger
  • Patent number: 5521184
    Abstract: There are described N-phenyl-2-pyrimidine-amine derivatives of formula I ##STR1## wherein R.sub.1 is 4-pyrazinyl, 1-methyl-1H-pyrrolyl, amino- or amino-lower alkyl-substituted phenyl wherein the amino group in each case is free, alkylated or acylated, 1H-indolyl or 1H-imidazolyl bonded at a five-membered ring carbon atom, or unsubstituted or lower alkyl-substituted pyridyl bonded at a ring carbon atom and unsubstituted or substituted at the nitrogen atom by oxygen, R.sup.2, R.sup.3, R.sup.9, X, Y, n and R.sup.10 are defined in claim 1These compounds can be used, for example, in the therapy of tumoral diseases.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: May 28, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Jurg Zimmermann
  • Patent number: 5516775
    Abstract: The invention relates to the use of known N-phenyl-2-pyrimidine derivatives for inhibiting proteinkinase C in warm-blooded animals as antitumor agents. ##STR1## The substituents in formula I are as defined in claim 1.
    Type: Grant
    Filed: August 6, 1993
    Date of Patent: May 14, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Jurg Zimmermann, Giorgio Caravatti