Patents Represented by Attorney, Agent or Law Firm Karen J. Messick
  • Intermediate release nicotinic acid compositions for treating hyperlipidemia
    Patent number: 6818229
    Abstract: Intermediate release nicotinic acid formulations having unique biopharmaceutical characteristics, such as Cmax, Tmax and AUC, which are suitable for oral administration once per day during the evening or at night for treating hyperlipidemia without causing drug-induced hepatotoxicity to such a level that requires the therapy to be discontinued, are disclosed. The intermediate nicotinic acid formulations can be administered as tablets in dosage strengths of, for example, 375 mg, 500 mg, 750 mg and 1000 mg.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: November 16, 2004
    Assignee: KOS Pharmaceuticals, Inc.
    Inventors: Eugenio A. Cefali, David J. Bova
  • Core formulation
    Patent number: 6780432
    Abstract: This invention relates to a combination drug product comprising pioglitazone hydrochloride and a biguamide, e.g. metformin. In particular, the product comprises a core of the biguamide, e.g. metformin, at least a portion thereof has a layer or coat thereon of pioglitazone.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: August 24, 2004
    Assignee: Aeropharm Technology, Inc.
    Inventors: Anthony J. Cutie, Akwete L. Adjei, Frederick A. Sexton
  • Modulated release particles for lung delivery
    Patent number: 6749845
    Abstract: A polymeric construct is disclosed. The construct comprises a polysaccharide polymer having a selected medicament associated therewith. The medicament thus present is provided in a slow release form.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: June 15, 2004
    Assignee: Aeropharm Technology, Inc.
    Inventors: Yaping Zhu, Simon G. Stefanos, Lukeysha Kline, Akwete L. Adjei