Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
Type:
Grant
Filed:
November 6, 2002
Date of Patent:
February 7, 2006
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr.
Abstract: Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
Type:
Grant
Filed:
July 23, 2003
Date of Patent:
January 24, 2006
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Ye Hua, Hiep The Luu, Fora P. Chan, Theodore O. Johnson, Jr., Siegfried Heinz Reich, Donald James Skalitzky, Yi Yang, Thomas F. Hendrickson, Shao Song Chu, Brian Walter Eastman
Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
Type:
Grant
Filed:
January 5, 1999
Date of Patent:
June 14, 2005
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr., Jayashree Girish Tikhe
Abstract: The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
Type:
Grant
Filed:
August 27, 2003
Date of Patent:
December 14, 2004
Assignee:
Pharmacia & Upjohn
Inventors:
Mark E. Schnute, Fred L. Ciske, Michael J. Genin, Joseph Walter Strohbach, Suvit Thaisrivongs
Abstract: The present invention provides a compound of the formula and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family.
Wherein:
X=O, (CH2)m, S, SO, SO2, NH, NR8;
Y=O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical bond;
Z=NH, O, NR8, S, SO, SO2;
The remaining substituents are described in the specification.
Type:
Grant
Filed:
July 5, 2002
Date of Patent:
October 5, 2004
Assignee:
Warner Lambert Company
Inventors:
Richard John Booth, Vara Prasad Venkata Nagendra Josyula, Annette Lynn Meyer, Bruce Allan Steinbaugh
Abstract: Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula I, as well as key intermediates useful in those synthetic routes. These compounds of formula I, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.
Type:
Grant
Filed:
October 30, 2001
Date of Patent:
August 10, 2004
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Qingping Tian, Naresh K. Nayyar, Srinivasan Babu, Junhua Tao, Terence Jarold Moran, Raymond Dagnino, Jr., Lennert J. Mitchell, Jr., Travis Paul Remarchuk, Michael Joseph Melnick, Steven Lee Bender
Abstract: Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.
Type:
Grant
Filed:
September 7, 2001
Date of Patent:
November 18, 2003
Inventors:
Peter S. Dragovich, Thomas J. Prins, Ru Zhou
Abstract: Compounds of the formula:
where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
Type:
Grant
Filed:
June 13, 2001
Date of Patent:
October 14, 2003
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Theodore O. Johnson, Jr., Shao Song Chu, Brian Walter Eastman, Ye Hua, Hiep The Luu, Siegfried Heinz Reich, Donald James Skalitzky, Yi Yang, Thomas F. Hendrickson, Fora P. Chan
Abstract: Compounds of the formula:
where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
Type:
Grant
Filed:
April 12, 2001
Date of Patent:
August 26, 2003
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Theodore O. Johnson Jr., Ye Hua, Hiep T. Luu, Peter S. Dragovich
Abstract: Compounds of the formula shown below are poly(ADP-ribosyl)transferase inhibitors:
Such compounds are useful as therapeutics in treating cancers and in ameliorating the effects of stroke, head trauma, and neurodegenerative disease.
Type:
Grant
Filed:
August 31, 2000
Date of Patent:
April 15, 2003
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Stephen Evan Webber, Donald James Skalitzky, Jayashree Girish Tikhe, Robert Arnold Kumpf, Joseph Timothy Marakovits, Brian Walter Eastman
Abstract: Compounds of the formula:
where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
Type:
Grant
Filed:
August 3, 2000
Date of Patent:
March 18, 2003
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Peter Scott Dragovich, Ru Zhou, Stephen Evan Webber, Thomas J. Prins, Siegfried Heinz Reich, Susan E. Kephart, Yuanjin Rui
Abstract: Peptido and peptidomimetic compounds of the formula:
wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
Type:
Grant
Filed:
April 29, 1999
Date of Patent:
March 11, 2003
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr.
Abstract: Compounds of the formula:
where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula:
where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.
Type:
Grant
Filed:
December 1, 2000
Date of Patent:
February 4, 2003
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Peter S. Dragovich, Thomas J. Prins, Ru Zhou, Theodore O. Johnnson, Jr.