Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
Type:
Grant
Filed:
September 7, 2000
Date of Patent:
January 21, 2003
Assignee:
Kosan Biosciences, Inc.
Inventors:
Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang