Patents Represented by Attorney, Agent or Law Firm Kate Murashige
  • Polyketide synthase enzymes and recombinant DNA constructs therefor
    Patent number: 6660862
    Abstract: Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: December 9, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Christopher Reeves, Daniel Chu, Chaitan Khosla, Daniel Santi, Kai Wu
  • Polyketide synthase genes from Streptomyces venezuelae
    Patent number: 6503741
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: January 7, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Recombinant production of novel polyketides
    Patent number: 6399382
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: June 4, 2002
    Assignees: The Leland Stanford Junior University, The John Innes Centre
    Inventors: Chaitan Khosla, David A. Hopwood, Susanne Ebert-Khosla, Robert McDaniel, Camilla Kao
  • Nucleic acids encoding narbonolide polyketide synthase enzymes from streptomyces narbonensis
    Patent number: 6303767
    Abstract: Host cells comprising recombinant vectors encoding the narbomycin polyketide synthase and narbomycin modification enzymes from Streptomyces narbonensis can be used to produce narbomycin, picromycin, methymycin, and neomethymycin. Recombinant DNA constructs comprising one or more narbomycin polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application in agriculture, medicine, and animal health.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: October 16, 2001
    Assignee: Kosan Biosciences, Inc.
    Inventors: Melanie C. Betlach, Robert McDaniel
  • Recombinant methods and materials for producing epothilones C and D
    Patent number: 6303342
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: October 16, 2001
    Assignee: Kason Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang
  • Production of polyketides in bacteria and yeast
    Patent number: 6258566
    Abstract: Hybrid and novel polyketide synthases (PKSs) and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of improved libraries of PKS and polyketides. In addition, polyketides can be produced in hosts that ordinarily do not produce polyketides by supplying, along with an expression system for the desired PKS, an expression system for holo acyl carrier protein (ACP) synthase.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: July 10, 2001
    Assignee: Kosan Biosciences, Inc.
    Inventors: Philip J. Barr, Daniel V. Santi, Gary W. Ashley, Rainer Ziermann
  • Recombinant oleandolide polyketide synthase
    Patent number: 6251636
    Abstract: Recombinant DNA compounds that encode all or a portion of the oleandolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of oleandolide, oleandolide derivatives, and polyketides that are useful as antibiotics and motilides.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: June 26, 2001
    Assignee: Kosan Biosciences, Inc.
    Inventors: Mary C. Betlach, Sanjay Krishnakant Shah, Robert McDaniel, Li Tang