Abstract: Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—R1)— group in the fused ring at the 1-position of the imidazo ring, wherein R1 includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract: There is provided a laminate of a thermoplastic backing to a fibrous web. This laminate, for example, could be used as a loop laminate for use in a hook and loop fastening system or an intermittently bonded elastic fibrous laminate. The laminate comprises a thermoplastic backing layer, having a first face and a second face. The backing layer has a plurality of projections extending from at least the first face of the backing. A fibrous web is attached to the backing at the location of at least some of the projections. The thermoplastic material of the backing, at the location of the projections, penetrates into the fibrous web encapsulating at least in part fibers of the fibrous web. The fibrous web preferably penetrates into at least some of the projections. The fibrous web is generally not attached, or very lightly attached, to the backing layer over at least some portion of the distance between adjacent projections.

Abstract: A chemical composition comprises one or more urethane oligomers of at least two polymerized units selected from the group consisting of fluorine-containing urethane oligomers and long-chain hydrocarbon-containing urethane oligomers, wherein said oligomers comprise the reaction product of (a) one or more polyfunctional isocyanate compounds, (b) one or more polyols, (c) one or more monoalcohols selected from the group consisting of fluorocarbon monoalcohols, optionally substituted long-chain hydrocarbon monoalcohols, and mixtures thereof, (d) one or more silanes, and (e) one or more stabilizers comprising one or more reactive groups.

Abstract: The invention provides a patch of a male fastening means, in particular, a hook patch with decreased bending resistance. The patch according to the invention comprises a backing bearing a plurality of male fastening elements, in particular hook elements. The patch is integral and comprises a plurality of incisions. Said incisions do not extend across the whole width of the patch but preferably leave at least one intact bridge across the cross-direction of the patch. Furthermore, a fastening tape tab having a manufacturer's and user's end is provided, the fastening tape tab comprising a support layer bearing on its major surface of the user's end at least one fastening patch according to the invention. Furthermore, a strip is provided from which a patch according to the invention is cut.

Abstract: Imidazoquinoline and imidazonaphthyridine compounds having a nitrogen-containing heterocyclyl substituent at the 5-, 6-, 7-, or 8-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract: The invention relates to a dilutable, non-aqueous concentrate and an aqueous dilution used for aqueous delivery of fluorinated oligomeric silanes to a substrate, a method of treating a substrate with the aqueous dilution composition to render it oil and water repellent, and articles having coatings made from the aqueous dilution.

Abstract: A nonplanar, thermoplastic polymeric film having a top surface, a bottom surface, a midline, and a series of peaks and valleys oscillating around the midline and forming continuous ridges in a first direction on both the top surface and the bottom surface of the film. The nonplanar, thermoplastic polymeric film has two or more polymer layers with at least one polymer layer partitioned disproportionally in the peaks such that at least two of the two or more polymer layers vary in thickness across the width of the nonplanar, thermoplastic polymeric film.

Abstract: Pyrazolo[3,4-c] ring compounds of Formula (I), e.g., pyrazolo[3,4-c]pyridines, pyrazolo[3,4-c]quinolines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and pyrazolo[3,4-c]naphthyridines, substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract: Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract: Pyrazolopyridine-1,4-diamines and analogs thereof, e.g., pyrazolo[3,4-c]pyridine-1,4-diamines, pyrazolo[3,4-c]quinoline-1,4-diamines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinoline-1,4-diamines, and pyrazolo[3,4-c]naphthyridine-1,4-di-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract: The present invention relates to a method of manufacturing a stretched mechanical fastening web laminate (1) comprising a thermoplastic web layer (13) having two major surfaces, one of the major surfaces bearing a multitude of male fastening elements (14) suitable for engagement with a corresponding female fastening material, and on its other major surface a fibrous web layer (11), said method comprising the steps of (i) providing the fibrous web layer (11) having an initial basis weight, (ii) passing the fibrous web layer (11) through a nip formed by two rolls (101), (103), one of them having cavities (120) that are the negatives of a plurality of male fastening elements (14), introducing a molten thermoplastic resin into the cavities (120) in excess of an amount that would fill the cavities (120) which excess forms the thermoplastic web layer (13), allowing the resin to at least partially solidify and stripping of a precursor web laminate (10) thus formed comprising the fibrous web layer (11) and the the

Abstract: Methods for coextruding a predetermined initial melt stream through at least one profiled die having a nonlinear inlet opening and an outlet opening. The die insert is positioned so as to cause redistribution of at least a portion of the melt stream. The nonlinear melt stream formed at the nonlinear inlet opening converges within the die insert into a substantially more linear or rectangular melt stream at the die insert outlet opening. At the die insert outlet opening at least one or more regions of the melt stream vary in properties or material clue to the redistribution of the melt stream in the die insert. Articles extruded using the coextrusion methods are also described.

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract: Described are coating compositions for treating substrates such as hard and soft surfaces to render the surfaces oil and water repellent, as well as stain and dirt resistant. The compositions described include three component systems in an organic solvent, where the components include a hydrolyzable perfluoropolyetherisocyanate derived silane, and to non-fluorinated components such as alkoxy silanes, one optionally containing a reactive functional group.

Abstract: Lipid-modified immune response modifier compounds, pharmaceutical compositions containing the compounds and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract: Described are polymeric surfactants which include a fluorinated moiety and a non-fluorinated moiety where the fluorinated moiety contains two perfluoro-lower-alkyl sulfonamido segments in proximity to each other ; the surfactants provide more efficient and effective lowering of the surface tension of liquids and increase of wetting of a coating on a substrate surface.

Abstract: The present invention provides a method for forming preferably a unitary polymeric hook fastener comprising a flexible backing, and a multiplicity of spaced hook members projecting from the upper surface of the unitary backing wherein each hook member comprises a multiplicity of hook head elements projecting in substantially the same direction. The hook members each comprise a stem portion attached at one end to the backing, and a head portion at the end of the stem portion opposite the backing. The head portion can also extend from a side of a stem portion or be omitted entirely to form alternative projections which can be other forms than a hook member. The head portion preferably projects past the stem portion on at least one of two opposite sides. At least the hook head portions have two or more hook head elements on at least one of the two opposing sides of the stem.

Abstract: An article including: a porous substrate that includes a fibrous material; and a release coating disposed on the fibrous material of the porous substrate; wherein the release coating includes a thermoplastic silicone-containing polymer. A method of making an article, which method includes: providing a porous backing having a first major surface and a second major surface; applying a pressure sensitive adhesive to the first major surface of the porous backing; and applying an aqueous dispersion including a thermoplastic silicone-containing polymer to the second major surface of the porous backing to form a low adhesion backsize.

Abstract: Fluorochemical oligomeric silanes, compositions comprising such silanes and/or the condensation products of such silanes, and coatings produced with such compositions.

Abstract: In one aspect, the invention provides a fluorochemical composition comprising a mixture of: a fluorochemical selected from the formula: wherein RF is a fluorinated group having the formula: Rf—W—, wherein Rf is a perfluoroalkyl or perfluoropolyether group and W is a divalent linking group; PI is a monovalent pendant organic moiety comprising benzophenone, substituted benzophenone, acetophenone, or substituted acetophenone groups; R is H, CH3, or F; Rh is lower alkyl selected from the group consisting of linear or branched alkyl groups having from 1 to about 8 carbon atoms, cycloalkyl-containing alkyl groups having from 4 to about 8 carbon atoms, and cycloalkyl groups having from 3 to about 8 carbon atoms, all optionally containing catenated O or N atoms; m is at least 2; n is at least 1; q is zero or greater; and a hydrofluoroether.