Abstract: The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiaz epi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ##STR1## The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). ##STR2## The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy.
Type:
Grant
Filed:
August 20, 1987
Date of Patent:
May 30, 1989
Assignee:
Biogal Gyogyszergyar
Inventors:
Jeno Korosi, Tibor Lang, Ferenc Andrasi, Pal Berzsenyi, Peter Botka, Tamas Hamori, Katalin G. Horvath, Jozsef Borsi, Istvan Elekes, Zsuzsanna L. Rihmer