Abstract: A method of stimulating homologous recombination by creating at least one nick in a targeted polynucleotide sequence. Wherein nonhomologous recombination is suppressed resulting in increasing the ratio of targeted to nontargeted events. A method of increasing double strand break-initiated gene targeting by inducing a nick in a targeted polynucleotide sequence, wherein overall recombination levels are increased. A method of increasing homologous recombination employing a recombinase that releases the ends in living cells by stimulating homolgous recombination to higher levels than those attainable with standard nucleases. A composition for stimulating homologous recombination including a nicking mechanism for creating nicks in a polynucleotide, wherein the nicking mechanism stimulates homologous recombination. A composition for stimulating homologous recombination including a nicking endonucleases. Various kits for stimulating homologous recombination.

Abstract: The present invention relates to a cell culture chamber (10) having a sterile environment (12) for the culture of cells, a cover (14) for allowing for a transfer of pits and a sensor array.

Abstract: There is provided a natural composition for boosting the libido of an individual, the composition including an effective amount of an aphrodisiac and a compound to increase blood flow to the pelvic area in a pharmaceutically acceptable carrier. A natural composition for boosting the libido of an individual, including an effective amount of a compound for driving blood flow to the penis and an aphrodisiac in a pharmaceutically acceptable carrier is also provided. Also provided is a method of increasing the libido by administering an effective amount of composition including an aphrodisiac and a compound to increase blood flow to the pelvic area in a pharmaceutically acceptable carrier.

Abstract: According to the present invention, there is provided an apparatus for collecting, disposing, and measuring liquids including a vessel with an inner surface and an absorption mechanism disposed on the inner surface of the vessel for absorbing and collecting liquids within the vessel. The present invention additionally provides for an absorption mechanism disposed on an inner surface of a vessel for preventing the spillage of any liquids, particularly those associated with excretory waste. Finally, the present invention provides for a method of using the apparatus claimed herein to collect, dispose, and measure liquid output from a bedridden individual.

Abstract: There is provided a composition having an effective amount of N-terminally truncated galectin-3 in a pharmaceutically acceptable carrier. Also provided by the present invention is a method of treating cancer by administering to a patient in need of such treatment an effective amount of N-terminally truncated galectin-3 in a pharmaceutically acceptable carrier.

Abstract: The invention relates to the use of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase type five (cGMP PDE V) inhibitor for increasing fecundity in a mammal by one or more of (a) promoting the growth of an oocyte, zygote, blastocyst, embryo and/or foetus, (b) increasing the rate or probability of survival of an embryo and/or foetus and (c) increasing the birth weight of a progeny, or for increasing milk productivity.

Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.

Abstract: A method for treating acute pancreatitis is disclosed. The method comprises administering to a patient with acute pancreatitis an effective amount of a suitable tumor necrosis factor (TNF) antagonist such as a TNF soluble receptor or a pharmaceutically acceptable salt thereof.

Abstract: Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D-2 receptor in the mammalian brain. The substituted benzamides and their racemic mixtures or their optically resolved enantiomers can be made by reacting a trialyltin substituted benzamide with an acid in the presence of radioactive iodine, generated by in situ oxidation of an appropriate iodide nuclide salt.

Abstract: A method of identifying atherosclerotic plaque versus structurally viable tissue includes the steps of emitting a fluorescent beam at a single excitation wavelength of between 350 and 390 nm at a tissue and detecting and quantifying the emission spectrum of the emitted beam at critical points chosen to optimize the difference between atherosclerotic plaque and structurally viable tissue. The presence of the atherosclerotic plaque is distinguished from structurally viable tissue by the presence or absence of the intensity of emissions at the critical points of optimum distinguishing wavelengths.

Abstract: A multi-product meat processing assembly (10) of the type for smoking meat includes a plurality of sequentially adjacent chambers (12,14,16,18,20,22) and trolley assemblies (26) for carrying meats hung from racks (24) through the chambers. An indexing mechanism (54) positions the racks (24) at predetermined positions within each of the chambers. The assembly (10) also includes telescoping doorways (74) separating the chambers. The assembly (10) further includes a reversible fan (132) for moving air in two directions through each of the chambers.

Abstract: A portable water purification system (10) includes a portable reservoir (12) for containing a contaminated water supply (14) and a separator module (48) for separating water and water soluble substance permeate from a contaminated water retentate. A permeate outlet (52) is operatively connected to the separator module (48) for releasing water and water soluble substances from the system (10). A return conduit (34) is operatively connected between the separator module (48) and the reservoir (12) for returning contaminated water retentate back to the reservoir (12). A plunger (54) is operatively connected to the reservoir (12) and includes an inlet chamber (32). The plunger draws contaminated water from the reservoir (12) and forces the contaminated water (32) through the separator module (48) so that the permeate flows out the permeate outlet (52) and the retentate flows out the return conduit (36).

Abstract: An adherent coating for calcium and magnesium containing minerals consists essentially of an integral block of the following structure: ##STR1## wherein R and R' are selected from the group including ethylene oxide, propylene oxide, vinyl, acrylic, methacrylate, styrene and combinations thereof. The present invention also provides a method of making the adherent coating and substrates with which it is effective.