Patents Represented by Attorney Kenneth J. Nussbacher

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  • Peptide library and screening method
    Patent number: 5270170
    Abstract: A random peptide library constructed by transforming host cells with a collection of recombinant vectors that encode a fusion protein comprised of a DNA binding protein and a random peptide and also encode a binding site for the DNA binding protein can be used to screen for novel ligands. The screening method results in the formation of a complex comprising the fusion protein bound to a receptor through the random peptide ligand and to the recombinant DNA vector through the DNA binding protein.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: December 14, 1993
    Assignee: Affymax Technologies N.V.
    Inventors: Peter J. Schatz, Millard G. Cull, Jeff F. Miller
  • Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
    Patent number: 5143854
    Abstract: Polypeptide arrays can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoremovable group to the activated regions, and repeating the steps of activation and attachment until polypeptides of the desired length and sequences are synthesized. The resulting array can be used to determine which peptides on the array can bind to a receptor.
    Type: Grant
    Filed: March 7, 1990
    Date of Patent: September 1, 1992
    Assignee: Affymax Technologies N.V.
    Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor, Lubert Stryer