Abstract: This invention relates generally to N-adamant-1-yl-N′-[4-chlorobenzothiazol-2-yl] urea, pharmaceutical compositions comprising the same, and methods of using the same in the treatment of inflammation and as an anticancer radiosensitizing agent.
Type:
Grant
Filed:
March 17, 2000
Date of Patent:
April 10, 2001
Assignee:
DuPont Pharmaceuticals Company
Inventors:
John J. V. Duncia, Daniel S. Gardner, IV, Joseph B Santella, III
Abstract: This invention provides a multilamellar liposome containing an arachidonic acid metabolite, two or more lipid-containing bilayers and two or more aqueous compartments containing a release-inhibiting buffer. Preferred arachidonic acid metabolites are the prostaglandins, particularly PGE.sub.1. The liposomal formulations can be used to treat animals, particularly humans, for diseases, disorders or conditions which can be ameliorated by prostaglandins, e.g., disorders characterized by cellular activation and adhesion, inflammation and/or toxemia.
Type:
Grant
Filed:
November 3, 1994
Date of Patent:
July 20, 1999
Assignee:
The Liposome Company, Inc.
Inventors:
Robert P. Lenk, Michelle L. Tomsho, Robert L. Suddith, Robert J. Klimchak, Andrew S. Janoff, Sharma R. Minchey, Marc J. Ostro
Abstract: A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with the liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use.Immunizing dosage forms comprising a liposome and an immunogen, wherein the liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen are present in an immunization dose, and method according to uses is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristolyphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein the DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.
Type:
Grant
Filed:
May 25, 1995
Date of Patent:
June 29, 1999
Assignee:
The Liposome Company, Inc.
Inventors:
Mircea C. Popescu, Alan L. Weiner, Marie S. Recine, Andrew S. Janoff, Leonard Estis, Lynn D. Keyes, Carl R. Alving