Patents Represented by Attorney, Agent or Law Firm Kerri P. Schray
  • Methods to identify compounds affecting mitochondria
    Patent number: 6183948
    Abstract: The present invention relates to methods for identifying a compound capable of modulating mitochondrial function, comprising contacting a eukaryotic cell with one or more candidate compounds, and detecting a change in the mitochondrial redox state of the cell. The methods further relates to such methods wherein endogenous fluorescence of the cell mitochondria is indicative of a change of redox state.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: February 6, 2001
    Assignee: Johns Hopkins University
    Inventors: Eduardo Marban, Brian O'Rourke