Patents Represented by Attorney, Agent or Law Firm Kevin Kaster
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Patent number: 6762168Abstract: The invention is directed towards antibacterial compounds. The invention concerns macrolide antibiotics useful as antiinfective agents.Type: GrantFiled: February 3, 2003Date of Patent: July 13, 2004Assignee: Kosan Biosciences, Inc.Inventor: Daniel T. W. Chu
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Patent number: 6627427Abstract: Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do not naturally produce the product or produce the product at low levels due to the absence of the precursor or the presence of the precursor in rate limiting amounts.Type: GrantFiled: October 25, 2000Date of Patent: September 30, 2003Assignee: Kosan Biosciences, Inc.Inventors: Leonard Katz, Peter Revill
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Patent number: 6589968Abstract: This present invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.Type: GrantFiled: April 3, 2001Date of Patent: July 8, 2003Assignee: Kosan Biosciences, Inc.Inventors: Robert L. Arslanian, John R. Carney, Brian Metcalf
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Patent number: 6583290Abstract: Compounds of the invention include 14-mehtyl epothilone derivatives. More generally, preferred compounds of the invention are those that can be produced by altering the epothilone PKS genes as described herein and optionally by action of epothilone modification enzymes and/or by chemically modifying the resulting epothilones produces when those genes are expressed.Type: GrantFiled: November 28, 2000Date of Patent: June 24, 2003Assignee: Kosam Biosciences, Inc.Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
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Patent number: 6562602Abstract: Fermentation based methods for producing mycolactones allows one to produce large quantities of mycolactones, which can be purified by extraction and chromatography to yield pure preparations of mycolactones A, B, C, and D.Type: GrantFiled: August 3, 2001Date of Patent: May 13, 2003Assignee: Kosan Biosciences, Inc.Inventors: Peter Licari, Robert Arslanian, Lawrence Cadapan, John Carney
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Patent number: 6509455Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.Type: GrantFiled: September 7, 2000Date of Patent: January 21, 2003Assignee: Kosan Biosciences, Inc.Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
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Patent number: 6503737Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.Type: GrantFiled: October 1, 1999Date of Patent: January 7, 2003Assignee: Kosan Biosciences, Inc.Inventors: Christopher Reeves, Daniel Chu, Chaitan Khosla, Daniel Santi, Kai Wu
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Patent number: 6503741Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.Type: GrantFiled: August 28, 1998Date of Patent: January 7, 2003Assignee: Kosan Biosciences, Inc.Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
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Patent number: 6492562Abstract: Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.Type: GrantFiled: January 27, 2000Date of Patent: December 10, 2002Assignee: Kosan Biosciences, Inc.Inventors: Gary Ashley, Isaac C. Chan-Kai, Mark A. Burlingame
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Patent number: 6489314Abstract: The present invention relates to 16-membered macrocyclic compounds. In one aspect of the present invention, compounds of the formula are provided wherein: R1, R2, R3, and R5 are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or alkylaryl; R4 is hydrogen, halogen, C1-C10 alkyl, C1-C10 hydroxyalkyl, C1-C10 haloalkyl, aryl, —C(═O)R6, —C(═O)OR6, —NR6R7 where R6 and R7 are each independently hydrogen, C1-C10 aliphatic, aryl or alkylaryl; W is O, NR8 where R8 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or alkylaryl; X is O, CH2 or a carbon-carbon double bond; Y is absent or a C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl; and Ar is aryl; provided that 10,11-dehydroepothilone C is excluded.Type: GrantFiled: April 3, 2001Date of Patent: December 3, 2002Assignee: Kosan Biosciences, Inc.Inventors: Gary Ashley, Brian Metcalf
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Patent number: 6451768Abstract: Compounds of the formula or the 10,11-anhydro forms thereof wherein Ra is F or OH; Rb is H or halogen; Rc is H or a protecting group; Rd is methyl; unsubstituted alkyl (3-10C); substituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C) or substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); substituted or unsubstituted arylalkenyl (5-20C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C); Re is H or a protecting group or is mono- or disubstituted amino carbonyl; Rf is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (1-10C); substituted or unsubstituted alkynyl (1-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); or —ORf may be replaced by &Type: GrantFiled: April 14, 2000Date of Patent: September 17, 2002Assignee: Kosan Biosciences, Inc.Inventor: Daniel T. W. Chu
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Patent number: 6410301Abstract: Recombinant Myxococcus host cell containing recombinant expression vectors containing epothilone polyketide synthase genes can produce epothilones C and D.Type: GrantFiled: April 28, 2000Date of Patent: June 25, 2002Assignee: Kosan Biosciences, Inc.Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla
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Patent number: 6403775Abstract: Genetic engineering of the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway can be used to generate a library of macrolides impractical to produce by chemical methods. The library includes examples of analogs with one, two and three altered carbon centers of the polyketide products.Type: GrantFiled: October 28, 1999Date of Patent: June 11, 2002Assignee: Kosan Biosciences, Inc.Inventor: Robert McDaniel
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Patent number: 6399382Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.Type: GrantFiled: March 5, 1999Date of Patent: June 4, 2002Assignees: The Leland Stanford Junior University, The John Innes CentreInventors: Chaitan Khosla, David A. Hopwood, Susanne Ebert-Khosla, Robert McDaniel, Camilla Kao
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Patent number: 6399789Abstract: A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS or NRPS products by tailoring enzymes.Type: GrantFiled: April 12, 2000Date of Patent: June 4, 2002Assignee: Kosan Biosciences, Inc.Inventors: Daniel V. Santi, Qun Xue, Gary Ashley
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Patent number: 6395710Abstract: Compounds of the formula wherein Ra is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20); or ORa is replaced by H; Rb is H or halogen; Rc is H or a protecting group; Rd is methyl, unsubstituted alkyl (3-10C); substituted alkyl (1-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); substituted or unsubstituted arylalkenyl (5-20C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C); Re is H or a protecting group; L is methylene or carbonyl; T is —O—, —N(R)—, —N(OR)—, —N(NHCOR)—, —N(N═CHR)—, or &mdaType: GrantFiled: April 14, 2000Date of Patent: May 28, 2002Assignee: Kosan Biosciences, Inc.Inventors: Daniel T. W. Chu, Gary Ashley
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Patent number: 6388099Abstract: The heterologous expression of the OlePKS in Streptomyces lividans, produces 8,8a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression with DEBS in S. lividans of the P450 monooxygenase OleP produces 8,8a-dihydroxy-6-deoxyerythonolide B and other derivatives that are precursors to important macrolide antibiotics.Type: GrantFiled: January 23, 2001Date of Patent: May 14, 2002Assignee: Kosan Biosciences, Inc.Inventor: Robert McDaniel
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Patent number: 6303767Abstract: Host cells comprising recombinant vectors encoding the narbomycin polyketide synthase and narbomycin modification enzymes from Streptomyces narbonensis can be used to produce narbomycin, picromycin, methymycin, and neomethymycin. Recombinant DNA constructs comprising one or more narbomycin polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application in agriculture, medicine, and animal health.Type: GrantFiled: November 5, 1999Date of Patent: October 16, 2001Assignee: Kosan Biosciences, Inc.Inventors: Melanie C. Betlach, Robert McDaniel
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Patent number: 6303342Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.Type: GrantFiled: November 19, 1999Date of Patent: October 16, 2001Assignee: Kason Biosciences, Inc.Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang
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Patent number: 6262340Abstract: The present invention provides genetically altered plants and plant cells that have been modified to contain expression system(s) capable of expressing a functional polyketide synthase (PKS). The present invention further provides methods of producing PKS and polyketides using these plants and cells.Type: GrantFiled: July 10, 1998Date of Patent: July 17, 2001Assignee: Kosan Biosciences, Inc.Inventors: Mary C. Betlach, James T. Kealey, Neal Gutterson, Ed Ralston