Patents Represented by Attorney Kevin Lyon & Lyon LLP Kaster

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  • Methods for diagnosis of conditions associated with elevated levels of telomerase activity
    Patent number: 5840495
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 24, 1998
    Assignee: University of Texas System Board of Regents
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • Methods and reagents for the identification and regulation of senescence-related genes
    Patent number: 5744300
    Abstract: Identification of senescence-related genes can be accomplished by comparing mRNA expression between young and senescent cells. Probes complementary to such genes can be used to detect senescent cells and distinguish between young and senescent cells as well as in screens to identify compounds that alter expression levels of senescence-related genes.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: April 28, 1998
    Assignee: Geron Corporation
    Inventors: Maarten H. K. Linskens, Kenneth S. Hirsch, Bryant Villeponteau, Junli Feng, Walter Funk, Michael David West