Abstract: Disclosed is a class of compounds referred to herein as effector compounds. Effector compounds are useful in connection with the modulation of an immune response. Modulation refers to the ability of the effector compounds of the present invention to either enhance (antigen supercharging) or inhibit (immunosuppressant activities) antigen presentation, depending upon the nature of the particular effector compound and the therapeutic context. Effector compounds include peptides, modified peptides and peptidomimetics. Also disclosed are methods for modulating presentation of an MHC class II restricted antigenic peptide to a T cell. Also disclosed are effector compounds demonstrated to act specifically on a human MHC class II allele. Also disclosed is a second class of compounds, referred to herein as immunomodulatory organic compounds.

Abstract: A system and method for controlling operation of a component include using at least two sensors arranged to sense an operating condition of the component. The system further includes a controller that controls the component in response to feedback signals output by one or more of the sensors. The controller also determines how the sensor feedback signals are to be used in controlling the component. To this end, the controller includes a model-based statistical filter for each one of the second sensors.

Abstract: Disclosed is a bandage for closing a wound or incision, and methods for the use of same. The bandage comprises a first flat flexible component having adhesive on a lower surface and one or more first elongated connectors extending in an offset manner from one edge thereof in a first direction. The bandage further comprises a second flat flexible component having adhesive on a lower surface and one or more second elongated connectors extending in an offset manner from one edge thereof in a second direction generally opposite to the first direction. Pulling elements are joined to the first and second elongated connectors. Means are provided for attaching the first elongated connectors to the second flat flexible component and the second elongated connectors to the first flat flexible component.

Abstract: Disclosed is a bandage for closing a wound or incision, and methods for the use of same. The bandage comprises a first flat flexible component having adhesive on a lower surface and one or more first elongated connectors extending in an offset manner from one edge thereof in a first direction. The bandage further comprises a second flat flexible component having adhesive on a lower surface and one or more second elongated connectors extending in an offset manner from one edge thereof in a second direction generally opposite to the first direction. Pulling elements are joined to the first and second elongated connectors. Means are provided for attaching the first elongated connectors to the second flat flexible component and the second elongated connectors to the first flat flexible component.

Abstract: A method of machining a chamber in a gun barrel by EDM, by using a conductive electrodes which defines the desired shape and dimensions of the chamber. A series of electrodes of progressively increasing diameter may be used. An electrode for an EDM barrel chambering process is an axisymmetrical conductive member, and may include a body, an angular shoulder, a neck, throat area, and a tapered lead angle portion into the bore along with other features of a selected cartridge chamber.

Abstract: A glass-ceramic cooktop appliance having at least one burner assembly disposed under a glass-ceramic plate. The cooktop appliance includes a sensor assembly having a support bar mounted on the burner assembly adjacent to the glass-ceramic plate and one or more devices for sensing cooktop related properties mounted on the support bar so as to be in contact with the glass-ceramic plate.

Abstract: Disclosed is a method for purifying a antibiotic from a crude or partially purified solution containing the lantibiotic. In preferred embodiments, the lantibiotic is nisin, although the common structural features of lantibiotics dictate the effectiveness of the disclosed purification methods for other members of the lantibiotic genus. The method includes the step of forming an incubation mixture comprising the solution containing the lantibiotic and a proteolytic enzyme, and incubating the mixture under conditions optimized for selective proteolytic activity.

Abstract: Disclosed is a method for producing an effective amount of one or more carotenoid, xanthophyll, or apo-carotenoid pigments from a microorganism from the Order Thraustochytriales. Suitable microorganisms put forth are of the genus Thraustochytrium and Schizochytrium. Preferred culture conditions and mediums are discussed. Examples are given of production of specific pigments, such as &bgr;-carotene, lutein, adonirubin, canthaxanthin, and astaxanthin, as are examples of methods of isolation of the pigment from the microorganism. Also disclosed is a food product that contains a microorganism from the Order Thraustochytriales, the microorganism having produced internally an effective amount of one or more carotenoid, xanthophyll, or apo-carotenoid pigments. The food product is used in a method for delivering one or more of the pigments to an animal or human for either pharmaceutical, nutritional or coloration purposes, by feeding the food product to the animal or human.

Abstract: Disclosed are epitope-containing heat shock fusion proteins, DNA constructs encoding such fusion proteins, and methods of use. More specifically, disclosed are ubiquitin fusion proteins comprising ubiquitin fused to a plurality of identical or non-identical epitopes at specified locations.

Abstract: A computer-implemented method for initiating forward motion in a vehicle equipped with a manual transmission. The method includes the steps of providing a sensor for determining clutch status; providing a sensor for determining when a transmission of a vehicle is in first gear; providing a throttle actuator calibrated to raise engine revolutions per minute from idle to a predetermined elevated level upon receipt of a throttle-up signal; and providing a control unit to receive inputs from the clutch and gear status sensors. The control unit is programmed to deliver the throttle-up signal to the throttle actuator when the sensor of clutch status indicates that a change in clutch status from engaged to non-engaged, and the gear sensor indicates that the vehicle is in first gear.

Abstract: Disclosed is a single-use surgical scalpel having two molded plastic elements, and a surgical blade. The first molded plastic element is a housing. The housing has an upper and a lower radiused edge, and ribbed interior wall surfaces. The ribbed interior wall surfaces of the molded plastic housing define a channel for slidable engagement of the second molded plastic element which is referred to as a blade carrier. The channel has one open end through which a surgical blade is extended during use, a slot through the lower radiused edge for slidable engagement of an actuator/locking fin, a single-use indicator window, and a retaining element for engaging a distal end of a leaf spring. The molded plastic blade carrier has a first end adapted for engaging the surgical blade, a second end having a leaf spring to assist in blade retraction, the leaf spring having a proximal and a distal end, and a central portion having the actuator/locking fin and a single-use indicator. A single-mold embodiment is also disclosed.

Abstract: Disclosed is a single-use syringe comprising a needle housing, a bore-containing fluid-delivery needle and a volume-containing element. The needle housing has a top surface to which the volume-containing element is attached, a needle attachment side to which the bore-containing needle is attached, and a fluid delivery channel in communication between the top surface and the needle attachment side. The volume-containing element is fluid-tight but for communication with the fluid-delivery and a filling port. Embodiments are disclosed which include vapor-permeable portions which facilitate lyophilization of materials in situ.

Abstract: This technique involves joining copper foils of any type and thickness to aluminum sheets of any alloy and thickness in order to simplify the assembly of multilayer press books, whereby two copper foils of any type and thickness and one aluminum sheet of any alloy and thickness are joined in such a way that the joint is located outside the surface of the aluminum separator. At the same time, the registration slots required for the multilayer press can be punched. The selected copper foil panels.are slightly larger than the aluminum sheet. When the aluminum separators thus covered with a copper foil on both sides are subsequently placed into the press together with the epoxy resin fabrics (prepregs) for laminating the multi-layer, the aluminum sheet can expand unhindered during heating without causing any surface tension on the copper foils.

Abstract: Delivery of metal particles to living tissue, then applying external energy that interacts with the metal particles, is found to selectively increase the energy deposition and interaction surrounding the metal particles. The method is useful to improve treatment of various conditions, since targeted cells may be selectively altered or killed. Metal particles are also loaded into cells or membrane vesicles by placing metal seed particles into the cells or vesicles, then chemically depositing additional metal on the metal seed particles. The metal particles are useful to improve imaging and therapies by their interaction with externally applied energy.

Abstract: Disclosed is a single-use syringe comprising a needle housing, a bore-containing fluid-delivery needle and a volume-containing element. The needle housing has a top surface to which the volume-containing element is attached, a needle attachment side to which the bore-containing needle is attached, and a fluid delivery channel in communication between the top surface and the needle attachment side. The volume-containing element is fluid-tight but for communication with the fluid-delivery and a filling port. Embodiments are disclosed which include vapor-permeable portions which facilitate lyophilization of materials in situ.

Abstract: Disclosed are antibodies which catalyze hydrolysis of &bgr;-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using &bgr;-amyloid peptides which incorporate transition state analogs are also provided. Also disclosed is a vectorized antibody which is characterized by the ability to cross the blood brain barrier, and is further characterized by the ability to catalyze the hydrolysis of &bgr;-amyloid. The vectorized antibody can take the form of a bispecific antibody, which has a first specificity for the transferrin receptor and a second specificity for a transition state adopted by &bgr;-amyloid during hydrolysis.

Abstract: Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from −550 to −487 in the promoter of the human TNF-&agr; gene. Additionally, the level of the mRNA transcript encoding the isolated polypeptide is substantially increased in response to LPS stimulation in cultured THP-1 cells.

Abstract: The present invention relates to an storage adapter used for engaging and supporting the stock/frame assembly of both the Contender® or Encore® brands of Thompson/Center Arms, Inc.® firearms. In a preferred embodiment of the present invention, the stock/frame assembly is stored in a vertical position above the floor of the gun cabinet/safe through the use of two individual components: (i) a novel storage adapter and (ii) a storage receiver which was previously-disclosed in U.S. patent application Ser. No. 09/705,081. The storage adapter component is comprised of a first end and a second end. The storage adapter engages, supports, and secures the stock/frame assembly by making use of the hinge pin of the firearm and a securing means (preferably a securing strap) to secure the stock/frame assembly to the second end of the storage adapter. The storage adapter, by use of a hanging means (preferably a hanging pin) in its first end, is then placed into (i.e.

Abstract: Disclosed is a method for in vivo imaging tissue of a individual, by performing magnetic resonance imaging utilizing an extended cobalt complex as a contrast enhancement agent. The extended cobalt complex is comprised of cobalt atoms, a carboxylate ligand, an amine ligand, and a multidentate thiol-containing organic ligand, the cobalt atoms being linked to thiol groups and counter ions. The extended cobalt complex is characterized as stable, water soluble, non-aggregating, magnetic, and from 0.5 to 10 nm in size. This method is especially useful in imaging tumor tissue, and also tissue which is regenerating from a wound. The extended cobalt complex can be specifically targeted to a particular tissue to enable selective imaging of that tissue. This is done by linking the extended cobalt complex to a binding moiety which specifically binds a molecule selectively expressed in the tissue.

Abstract: Large cobalt and nickel complexes that may be linked to antibodies and other molecules are described. These may be useful in applications benefiting from their magnetic properties.