Patents Represented by Attorney Kevin M. Foley

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  • Low molecular weight heparin derivatives having improved anti-Xa specificity
    Patent number: 4942156
    Abstract: Ester derivatives of low molecular weight heparin are disclosed. These derivatives exhibit improved Anti-Xa activity in relation to global anticlotting activity.
    Type: Grant
    Filed: August 20, 1986
    Date of Patent: July 17, 1990
    Assignee: Hepar Industries, Inc.
    Inventors: Kevin M. Foley, Charles C. Griffin, Eduardo Amaya
  • Oligo-heteropolysaccharides having a heparin-like activity method for their preparation and pharmaceutical compositions based thereon
    Patent number: 4757057
    Abstract: A oligo-heteropolysaccharide is disclosed which is very active against thrombotic syndromes and is prepared starting from depolymerized heparin fractions wherein the active groups, more particularly the sulfuric groups have been reconstituted by reacting a heparin fraction with a mol wt from 2,000 to 5,000 with the sulfotrioxide of a nitrogeneous organic base such as pyridine and trimethylamine. The method of preparation is also disclosed.
    Type: Grant
    Filed: January 7, 1986
    Date of Patent: July 12, 1988
    Assignee: Hepar Chimie S.A.
    Inventors: Fernando Fussi, Gianfranco Fedeli
  • Method for tumor regression in rats, mice and hamsters using hexuronyl hexosaminoglycan-containing compositions
    Patent number: 4757056
    Abstract: Regression of established malignant tumors in rats, mice and hamsters is achieved with a combination of the heparin fragment hexuronyl hexosaminoglycan sulfate (HHS) together with a steroid such as hydrocortisone. HHS is clinically useful for its antineoplastic, inhibiting effects in tumor systems in rats, mice and hamsters.
    Type: Grant
    Filed: April 26, 1985
    Date of Patent: July 12, 1988
    Assignee: Hepar Industries, Inc.
    Inventors: Cornelius L. Van Gorp, Thomas M. Wolf